Results 71 to 80 of about 11,722 (165)
Brain Pathology, Volume 35, Issue 5, September 2025.Default mode network (DMN) consists, in part, of the frontal (FC), precuneus (PreC), and posterior cingulate cortex (PCC), which plays a critical role in episodic memory and retrieval of autobiographical memories, displays spatiotemporal differences in the onset of amyloid and hypometabolism that reflects tau neurodegeneration and loss of connectivity ...
Sylvia E. Perez +8 more
wiley +1 more source
Alternative Splicing Regulation in Metabolic Disorders
Obesity Reviews, Volume 26, Issue 9, September 2025.ABSTRACT Alternative splicing (AS) is a fundamental mechanism for enhancing transcriptome diversity and regulating gene expression, crucial for various cellular processes and the development of complex traits. This review examines the role of AS in metabolic disorders, including obesity, weight loss, dyslipidemias, and metabolic syndrome.
Dorota Kaminska
wiley +1 more source
The Plant Journal, Volume 123, Issue 5, September 2025.Significance Statement Thermospermine negatively regulates xylem formation through enhancing mRNA translation of the SAC51 family in Arabidopsis. Isolation and characterization of thermospermine‐insensitive mutants named its reveals the involvement of RNA processing/modification in the action of thermospermine. Thermospermine functions to repress xylem
Mitsuru Saraumi +6 more
wiley +1 more source
The special Sm core structure of the U7 snRNP: far-reaching significance of a small nuclear ribonucleoprotein [PDF]
, 2018 .: The polypeptide composition of the U7 small nuclear ribonucleoprotein (snRNP) involved in histone messenger RNA (mRNA) 3′ end formation has recently been elucidated.
Pillai, R., Schümperli, D.
core
SmD3 regulates intronic noncoding RNA biogenesis [PDF]
, 2012 Accumulation of excess lipid in nonadipose tissues is associated with oxidative stress and organ dysfunction and plays an important role in diabetic complications.
Michel, Carlos I +3 more
core +2 more sources
EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways
Advanced Science, Volume 12, Issue 32, August 28, 2025.EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen +12 more
wiley +1 more source
Genome-wide identification of genes involved in growth and fermentation activity at low temperature in Saccharomyces cerevisiae [PDF]
, 2016 Fermentation at low temperatures is one of the most popular current winemaking practices because of its reported positive impact on the aromatic profile of wines.
García Ríos, Estéfani +7 more
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U1‐70K and U1A and tau pathogenesis in demented and non‐demented individuals with Down syndrome
Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.Abstract INTRODUCTION Splicing protein mislocalization is associated with tau pathogenesis, but its role in Down syndrome (DS) is under‐investigated. METHODS Spliceosome associations with tau and plaque pathology were examined in frontal cortex from DS with dementia (DSD+) and without dementia (DSD−) using quantitative immunoblotting and ...
Sylvia E. Perez +6 more
wiley +1 more source
U12 intron positions are more strongly conserved between animals and plants than U2 intron positions [PDF]
, 2008 We report that the positions of minor, U12 introns are conserved in orthologous genes from human and Arabidopsis to an even greater extent than the positions of the major, U2 introns.
Malay KUMAR Basu +3 more
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Clinical and Translational Medicine, Volume 15, Issue 8, August 2025.LncRNAs are localized in cytosol, nucleus, other sub‐nuclear compartments, and exosomes in the cell, and play significant role in lung cancer dissemination based on their localizations. LncRNAs have emerged as promising biomarkers for both early detection and prognosis.
Musaffe Tuna +2 more
wiley +1 more source