Results 51 to 60 of about 11,722 (165)

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Interaction of Newcastle disease virus V protein with EFTUD2 modulates MDA5 pathway to suppress viral replication

Poultry Science
Elongation factor Tu GTP-binding domain-containing protein 2 (EFTUD2), a core component of U5 small nuclear ribonucleoprotein particles (snRNPs), recently emerged as a novel innate immune regulator.
Yin Han, Fan Zhang, Ziqing Zhou, Yufang Huang, Ruiai Chen   +4 more
doaj   +1 more source

Interactome analysis brings splicing into focus [PDF]

, 2015
The spliceosome is a huge molecular machine that assembles dynamically onto its pre-mRNA substrates. A new study based on interactome analysis provides clues about how splicing-regulatory proteins modulate assembly of the spliceosome to either activate ...
Burge, Christopher B., Dominguez, Daniel
core   +2 more sources

The transcriptome of the invasive eel swimbladder nematode parasite Anguillicola crassus [PDF]

, 2013
BACKGROUND: Anguillicola crassus is an economically and ecologically important parasitic nematode of eels. The native range of A. crassus is in East Asia, where it infects Anguilla japonica, the Japanese eel. A. crassus was introduced into European eels,
Blaxter, Mark, Bridgett, Stephen, Heitlinger, Emanuel, Montazam, Anna, Taraschewski, Horst   +4 more
core   +2 more sources

Nuclear Condensates of WW Domain‐Containing Adaptor With Coiled‐Coil Regulate Mitophagy via Alternative Splicing

Advanced Science
Biomolecular condensates segregate nuclei into discrete regions, facilitating the execution of distinct biological functions. Here, it is identified that the WW domain containing adaptor with coiled‐coil (WAC) is localized to nuclear speckles via its WW ...
Jiahe Wang, Yi Fan, Guowen Luo, Liang Xiong, Lijie Wang, Zhuoxuan Wu, Jiayi Wang, Zhengying Peng, Clifford J Rosen, Kefeng Lu, Junjun Jing, Quan Yuan, Zhenwei Zhang, Chenchen Zhou   +13 more
doaj   +1 more source

Trimethylguanosine nucleoside inhibits cross-linking between snurportin 1 and m3G-capped U1 snRNA [PDF]

, 2015
Macromolecular nuclear import is an energy-and signal-dependent process. The best characterized type of nuclear import consists of proteins carrying the classical NLS that is mediated by the heterodimeric receptor importin α/β. Spliceosomal snRNPs U1, U2,
Aviñó, Anna, Bach-Elias, Montse, Bahia, Diana, Darzynkiewicz. Edward, Eritja Casadellà, Ramón   +4 more
core   +2 more sources

Gezielte Modulation des spliceosomalen Proteins USP39 durch allosterische Liganden und PROTAC‐induzierte Degradation

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Proteolysis‐targeting Chimeras (PROTACs) ermöglichen die gezielte Degradation bislang als „undruggable“ geltende Proteine über das zelluläre Ubiquitin–Proteasom‐System. In dieser Studie identifizieren Schäfer et al. thiazolbasierte niedermolekulare Liganden, die allosterisch an die Zinkfinger‐Domäne der Ubiquitin‐spezifischen Protease 39 (USP39) binden
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source

A general approach for identification of RNA-protein cross-linking sites within native human spliceosomal small nuclear ribonucleoproteins (snRNPs). Analysis of RNA-protein contacts in native U1 and U4/U6.U5 snRNPs.

The Journal of biological chemistry, 2001
We describe a novel approach to identify RNA-protein cross-linking sites within native small nuclear ribonucleoprotein (snRNP) particles from HeLa cells. It combines immunoprecipitation of the UV-irradiated particles under semi-denaturing conditions with primer extension analysis of the cross-linked RNA moiety.
H, Urlaub, K, Hartmuth, S, Kostka, G, Grelle, R, Lührmann   +4 more
openaire   +2 more sources

Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC‐Induced Degradation

Angewandte Chemie International Edition, Volume 65, Issue 5, 28 January 2026.
Proteolysis‐targeting chimeras (PROTACs) enable degradation of proteins previously considered undruggable by harnessing the cellular ubiquitin–proteasome system. In this study, Schäfer et al. identify thiazole‐based small molecules that allosterically bind the zinc finger domain of ubiquitin‐specific protease 39 (USP39), a non‐enzymatic scaffold ...
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source

An in vivo genetic screen for genes involved in spliced leader trans-splicing indicates a crucial role for continuous de novo spliced leader RNP assembly [PDF]

, 2017
ACKNOWLEDGEMENTS Some strains were provided by the CGC, which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440). We would also like to thank Prof.
Albrecht, Allen, Barbee, Bell, Bernadette Connolly, Berndt Müller, Blumenthal, Blumenthal, Brahms, Brahms, Brenner, Bruzik, Conrad, Denker, Denker, Evans, Evans, Evans, Ferguson, Friesen, Fr⊘kjær-Jensen, George C. Pandarakalam, Godfrey, Hannon, Jonathan Pettitt, Jones, Kamath, Kamath, Kutscher, Lasda, Lasda, Li, Lucas Philippe, MacMorris, Maroney, Meister, Neale Harrison, Paushkin, Pellizzoni, Pettitt, Pettitt, Pillai, Pillai, Reuter, Rotimi Fasimoye, Ruegger, Schmittgen, Schneider, Sonnichsen, Stiernagle, Thomas, Timmons, Van Doren, Van Doren, Whitelaw   +54 more
core   +1 more source