Results 41 to 50 of about 11,722 (165)

Mud2 functions in transcription by recruiting the Prp19 and TREX complexes to transcribed genes [PDF]

, 2007
The different steps of gene expression are intimately linked to coordinate and regulate this complex process. During transcription, numerous RNA-binding proteins are already loaded onto the nascent mRNA and package the mRNA into a messenger ...
Andersen, Ulrik L., Corney, Joel F., Dong, Rui-Fang, Drummond, P. D., Elser, Dominique, Heersink, Joel, Huck, Alexander, Leuchs, G., Milanovic, Josip   +8 more
core   +1 more source

Perlman syndrome nuclease DIS3L2 controls cytoplasmic non-coding RNAs and provides surveillance pathway for maturing snRNAs [PDF]

, 2016
The exosome-independent exoribonuclease DIS3L2 is mutated in Perlman syndrome. Here, we used extensive global transcriptomic and targeted biochemical analyses to identify novel DIS3L2 substrates in human cells.
Bijata, Krystian, Dziembowski, Andrzej, Krawczyk, Paweł, Kuliński, Tomasz M., Tomecki, Rafał, Warkocki, Zbigniew, Łabno, Anna   +6 more
core   +1 more source

Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors [PDF]

, 1994
We have examined the functional significance of the organization of pre-mRNA splicing factors in a speckled distribution in the mammalian cell nucleus. Upon microinjection into living cells of oligonucleotides or antibodies that inhibit pre-mRNA splicing
Krainer, A. R., Mayeda, A., O'Keefe, R. T., Sadowski, C. L., Spector, D. L.   +4 more
core   +2 more sources

A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II [PDF]

, 2014
Cajal bodies are nuclear structures that are involved in biogenesis of snRNPs and snoRNPs, maintenance of telomeres and processing of histone mRNA. Recently, the SUMO isopeptidase USPL1 was identified as a component of Cajal bodies that is essential for ...
Andersen, Baillat, Bauer, Blencowe, Boisvert, Boulisfane, Broome, Campion, Carmo-Fonseca, Chen, Cioce, Collier, Cox, Cox, Cuello, Darzacq, Dundr, Durocher, Egloff, Fischer, Fischer, Fischer, Fischer, Frey, Gabanella, Ganot, Gao, Hamm, Handwerger, Hegele, Hu, Huang, Huang, Hutten, Jacobs, Jao, Jawdekar, Jády, Kambach, Kiss, Kiss, Klingauf, Kunkel, Lange, Lemm, Lindgren, Listerman, Liu, Machyna, Makarov, Mao, Massenet, Matera, Matera, Mattaj, Medlin, Meulmeester, Morris, Mouaikel, Novotný, O'Keefe, Ong, Ong, Patel, Pellizzoni, Plessel, Polak, Raška, Reddy, Sauterer, Schaffert, Schulz, Shav-Tal, Shevchenko, Sleeman, Sleeman, Smith, Smith, Sowa, Spector, Spector, Spector, Spector, Stanek, Stanek, Strzelecka, Taneja, Tucker, Tycowski, Van Arsdell, Wahl, Westin, Will, Yin, Zhang, Zhao   +95 more
core   +5 more sources

A label free chemoproteomic-based platform to disclose cannabidiol molecular mechanism of action on chronic myelogenous leukemia cancer cells

Heliyon
The discovery of the interactome of cannabidiol (CBD), a non-psychoactive cannabinoid from Cannabis sativa L., has been here performed on chronic myelogenous leukemia cancer cells, using an optimized chemo-proteomic stage, which links Drug Affinity ...
Sara Ceccacci, Lorenzo Corsi, Lucio Spinelli, Clarissa Caroli, Matilde Marani, Lisa Anceschi, Matteo Mozzicafreddo, Federica Pellati, Maria Chiara Monti   +8 more
doaj   +1 more source

The spliceosome, a potential Achilles heel of MYC-driven tumors [PDF]

, 2015
Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome - the core splicing machinery - that are essential for malignant transformation driven by the ...
Anczukow, O., Krainer, A. R.
core   +1 more source

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

Multiple splicing factors are released from endogenous complexes during in vitro pre-mRNA splicing [PDF]

, 1989
Pre-mRNA splicing occurs in a macromolecular complex called the spliceosome. Efforts to isolate spliceosomes from in vitro splicing reactions have been hampered by the presence of endogenous complexes that copurify with de novo spliceosomes formed on ...
Conway, G. C., Krainer, A. R., Spector, D. L., Roberts, R. J.   +3 more
core  

Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells [PDF]

, 1990
SF2, an activity necessary for 5' splice site cleavage and lariat formation during pre-mRNA splicing in vitro, has been purified to near homogeneity from HeLa cells. The purest fraction contains only two related polypeptides of 33 kD.
Conway, G. C., Kozak, D., Krainer, A. R.   +2 more
core   +1 more source

Electron microscopy of small nuclear ribonucleoprotein (snRNP) particles U2 and U5: evidence for a common structure-determining principle in the major U snRNP family.

Proceedings of the National Academy of Sciences, 1990
We have studied by electron microscopy the structures of native small nuclear ribonucleoprotein (snRNP) particles U2 and U5 from HeLa cells. The structure of native U2 snRNP is characterized by a main body 8 nm in diameter with one additional domain about 4 nm long and 6 nm wide.
B, Kastner, M, Bach, R, Lührmann
openaire   +3 more sources