Results 81 to 90 of about 11,722 (165)

Proteomic analysis of interchromatin granule clusters [PDF]

, 2004
A variety of proteins involved in gene expression have been localized within mammalian cell nuclei in a speckled distribution that predominantly corresponds to interchromatin granule clusters (IGCs).
Saitoh, N., Spahr, C. S., Patterson, S. D., Bubulya, P., Neuwald, A. F., Spector, D. L.   +5 more
core   +1 more source

Selective Recruitment of Nuclear Factors to Productively Replicating Herpes Simplex Virus Genomes [PDF]

, 2015
Much of the HSV-1 life cycle is carried out in the cell nucleus, including the expression, replication, repair, and packaging of viral genomes. Viral proteins, as well as cellular factors, play essential roles in these processes. Isolation of proteins on
DeLuca, NA, Dembowski, JA
core   +4 more sources

A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing [PDF]

, 2015
Prp3 is an essential U4/U6 di-snRNP-associated protein whose functions and molecular mechanisms in pre-mRNA splicing are presently poorly understood. We show by structural and biochemical analyses that Prp3 contains a bipartite U4/U6 di-snRNA-binding ...
Bujnicki, Janusz M., Dunin-Horkawicz, Stanislaw, Fabrizio, Patrizia, Liu, Sunbin, Lührmann, Reinhard, Mozaffari-Jovin, Sina, Santos, Karine F., Theuser, Matthias, Wahl, Markus C., Wollenhaupt, Jan   +9 more
core   +1 more source

The intriguing case of motor neuron disease: ALS and SMA come closer [PDF]

, 2013
MNDs (motor neuron diseases) form a heterogeneous group of pathologies characterized by the progressive degeneration of motor neurons. More and more genetic factors associated with MND encode proteins that have a function in RNA metabolism, suggesting ...
Achsel, T, Barabino, S, Carrì, MT, Cozzolino, M   +3 more
core   +1 more source

Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor.

The Journal of biological chemistry, 2002
In the androgen receptor (AR), most of its transactivation activity is mediated via the activation function-1 (AF-1). By employing yeast two-hybrid assay, we isolated a cDNA sequence encoding a protein binding to AR-AF-1. This protein, named ANT-1 (AR N-terminal domain transactivating protein-1), enhanced the ligand-independent autonomous AF-1 ...
Yue, Zhao, Kiminobu, Goto, Masayuki, Saitoh, Toshihiko, Yanase, Masatoshi, Nomura, Taijiro, Okabe, Ryoichi, Takayanagi, Hajime, Nawata   +7 more
openaire   +1 more source

The Spliceosomal Protein Prp8 Stabilizes A Compact Conformation Of The U2-U6 Complex [PDF]

, 2012
The spliceosome is a large, RNA-protein complex that catalyzes pre-mRNA splicing during mRNA maturation. The RNA components (small nuclear RNA; snRNAs) of the spliceosome have been well studied and are believed to be involved in the splicing catalysis ...
Subasinghe, Subasinghe Appuhamilage Lemintha Imali
core   +1 more source

Isolation of small nuclear ribonucleoproteins containing U1, U2, U4, U5, and U6 RNAs.

Journal of Biological Chemistry, 1983
M, Hinterberger, I, Pettersson, J A, Steitz   +2 more
openaire   +2 more sources

Experimental Rnomics : : Towards The Identification And Characterization Of Non-Protein-Coding Ribonucleic Acids In Pathogenic Agents, Salmonella Typhi [PDF]

, 2009
This thesis focused on the experimental identification of small npcRNAs from Salmonella enterica serovar Typhi (S. Typhi), the aetiological agent of typhoid fever.
Zakaria, Robaiza
core  

Human MFAP1 is a cryptic ortholog of the Saccharomyces cerevisiae Spp381 splicing factor [PDF]

, 2017
Alexander K. C. Ulrich, Markus C. Wahl
core   +1 more source

Exploring Disordered Regions of Human Spliceosome Proteins. [PDF]

J Phys Chem Lett
Santos BPO, Bera K, Grisanti L, Felli IC, Pierattelli R, Magistrato A.   +5 more
europepmc   +1 more source