Results 41 to 50 of about 18,020 (210)

RIPK1 regulates starvation resistance by modulating aspartate catabolism [PDF]

Nature Communications, 2021
AbstractRIPK1 is a crucial regulator of cell death and survival. Ripk1 deficiency promotes mouse survival in the prenatal period while inhibits survival in the early postnatal period without a clear mechanism. Metabolism regulation and autophagy are critical to neonatal survival from severe starvation at birth.
Xinyu Mei, Yuan Guo, Zhangdan Xie, Yedan Zhong, Xiaofen Wu, Daichao Xu, Ying Li, Nan Liu, Zheng-Jiang Zhu   +8 more
openaire   +3 more sources

Discovery of a cooperative mode of inhibiting RIPK1 kinase

Cell Discovery, 2021
RIPK1, a death domain-containing kinase, has been recognized as an important therapeutic target for inhibiting apoptosis, necroptosis, and inflammation under pathological conditions.
Huyan Meng, Guowei Wu, Xinsuo Zhao, Anhui Wang, Dekang Li, Yilun Tong, Taijie Jin, Ye Cao, Bing Shan, Shichen Hu, Ying Li, Lifeng Pan, Xiaoxu Tian, Ping Wu, Chao Peng, Junying Yuan, Guohui Li, Li Tan, Zhaoyin Wang, Ying Li   +19 more
doaj   +1 more source

Triggering necroptosis in cisplatin and IAP antagonist-resistant ovarian carcinoma. [PDF]

, 2014
Ovarian cancer patients are typically treated with carboplatin and paclitaxel, but suffer a high rate of relapse with recalcitrant disease. This challenge has fostered the development of novel approaches to treatment, including antagonists of the ...
Axelrod, J, Bacos, K, Cosford, NDP, Delaney, JR, Lu, D, McCabe, KE, Potter, MD, Stupack, DG, Vamos, M, Wong, V, Xiang, R   +10 more
core   +2 more sources

Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells

Molecular & Cellular Oncology, 2019
A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells.
Shawn T. Beug, Robert G. Korneluk, Eric C. LaCasse   +2 more
doaj   +1 more source

RIPK1 Regulates Microglial Activation in Lipopolysaccharide-Induced Neuroinflammation and MPTP-Induced Parkinson’s Disease Mouse Models

Cells, 2023
Increasing evidence suggests a pivotal role of receptor-interacting protein kinase 1 (RIPK1), an initiator of necroptosis, in neuroinflammation. However, the precise role of RIPK1 in microglial activation remains unclear.
Do-Yeon Kim, Yea-Hyun Leem, Jin-Sun Park, Jung-Eun Park, Jae-Min Park, Jihee Lee Kang, Hee-Sun Kim   +6 more
doaj   +1 more source

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 [PDF]

, 2014
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as ‘accidental cell death’ (ACD).
A Ciechanover, A Criollo, A Degterev, A Degterev, A Degterev, A Gross, A Hochreiter-Hufford, A Kaczmarek, A Linkermann, A Linkermann, A Linkermann, A Linkermann, A Nagasaka, A Oberst, A Oberst, A Pogrebniak, A Rebbaa, A Strasser, A Villunger, AA Fatokun, AA Mailleux, AC Schinzel, AD Dam, AG Fraser, AJ Schile, AM Chinnaiyan, AM Chinnaiyan, AM Choi, AM Verhagen, AU Lindner, AV Vaseva, B D Dynlacht, B Joseph, B La Scola, B La Scola, B Levine, B R Stockwell, B Zhivotovsky, B Zhivotovsky, BA Gibson, BB Wolf, BH Han, C Borner, C Brenner, C Brenner, C Brenner, C Brenner, C Du, C Garrido, C Garrido, C López-Otín, C M Rodrigues, C Munoz-Pinedo, C Muñoz-Pinedo, C Scaffidi, C Scheller, C Volbracht, C Volbracht, CM Haynes, CO Bellamy, CP Baines, CP Baines, CP Dillon, D Adam, D Andrews, D C Rubinsztein, D Chandra, D Denton, D Denton, D Denton, D Denton, D Denton, D E Bredesen, D Grander, D J Klionsky, D R Green, D Raoult, D Ren, D Vercammen, D Vercammen, D Vercammen, D Xue, D Zhu, DA Fruman, DC Rubinsztein, DE Bredesen, DJ Klionsky, DL Berry, DL Vaux, DM Moujalled, DM Moujalled, DM Underhill, DR Green, DR Green, DV Krysko, DV Krysko, DW Zhang, E Basso, E Candi, E F Wagner, E H Baehrecke, E H Cheng, E Laane, E Lugli, E Murphy, E Noch, E S Alnemri, E Tasdemir, E White, E White, EA Minina, EA Slee, EA Slee, EH Baehrecke, EJ Park, F Basit, F Cecconi, F Cecconi, F Gonzalvez, F K Chan, F Madeo, F Pietrocola, F Verrier, FC Kischkel, FH Igney, G A Rabinovich, G Denecker, G Hajnoczky, G Kroemer, G Kroemer, G Kroemer, G Kroemer, G Kroemer, G Kroemer, G Kroemer, G Lettre, G M Fimia, G Marino, G Melino, G Nuñez, G Szabadkai, G Trichonas, G Van Loo, GP Sims, H Gronemeyer, H Ichijo, H Kanuka, H Kenis, H Khalil, H Kim, H L Tang, H Pearson, H Puthalakath, H Puthalakath, H Puthalakath, H Varma, H Wajant, H Walczak, H Walczak, H Wang, H Yoshida, H Zhu, H Zou, H-U Simon, HI Roach, HL Tang, HL Tang, I Amelio, I Martinou, I Vitale, IK Poon, IP Nezis, J A Cidlowski, J E Chipuk, J H Prehn, J Hitomi, J J Lemasters, J Li, J M Abrams, J M Bravo-San Pedro, J M Hardwick, J M Penninger, J Michels, J P Medema, J Sosna, J Wu, J Yang, J Yuan, J Yuan, J Zhao, J-C Marine, J-C Martinou, JA Rickard, JC Reed, JE Chipuk, JE Chipuk, JE Vince, JF Kerr, JG Albeck, JG Albeck, JH Shin, JJ Lemasters, JL Luo, JM Hardwick, JM Murphy, JS Long, JU Schweichel, JW Upton, K Bianchi, K Blomgren, K Kehe, K Kuida, K Kuida, K Miyazaki, K Newton, K Nihira, K Prabhakaran, K Richter, K S Ravichandran, K Segawa, K Tracy, K-M Debatin, KA Spriggs, KC Zimmermann, KN Alavian, KR Knight, L Altucci, L Duprez, L Galluzzi, L Galluzzi, L Galluzzi, L Galluzzi, L Galluzzi, L Galluzzi, L Galluzzi, L Galluzzi, L Galluzzi, L Mondragon, L Steinhart, L Sun, L Zitvogel, LC Gomes, M Ankarcrona, M Annicchiarico-Petruzzelli, M Arundine, M Bonora, M Campanella, M Campanella, M Chautan, M D'Amelio, M E Peter, M Elgendy, M Endres, M Irmler, M J Bertrand, M Leist, M Los, M MacFarlane, M Mediavilla-Varela, M Muzio, M O Hengartner, M Okada, M Overholtzer, M Piacentini, M V Blagosklonny, M Woo, M-L Gougeon, MA Burguillos, MA Hughes, MA Mellen, MA Mellen, MA O'Donnell, MB Jensen, MC Wei, ME Peter, MJ Bertrand, ML Coleman, N Di Daniele, N G Bazan, N Holler, N Honarpour, N Mizushima, N Mizushima, N S Chandel, N Tavernarakis, N Vanlangenakker, N Vanlangenakker, N Vanlangenakker, NJ Curtin, NJ McCarthy, NN Danial, O Kepp, O Kepp, O Krysko, P Bouillet, P Golstein, P J Jost, P Kraft, P Li, P Mazzarello, P Meier, P Nicotera, P Nicotera, P Pacher, P Pinton, P Saikumar, P Schotte, P Vandenabeele, P Vandenabeele, P Vandenabeele, P Vandenabeele, PE Czabotar, PG Clarke, PJ Jost, PS Brookes, Q Remijsen, Q Zhang, R A Flavell, R A Knight, R A Lockshin, R De Maria, R Hakem, R Rashmi, R Rizzuto, R Skouta, R Weinlich, RA Lockshin, RA Lockshin, RC Taylor, RJ O'Brien, RM del Moral, RU Janicke, RW Oppenheim, S A Aaronson, S A Lipton, S Barut, S Bhattacharyya, S Dolma, S Enzenmuller, S Fulda, S Fulda, S Grootjans, S He, S J Martin, S Jouan-Lanhouet, S Kumar, S Kumar, S Melino, S Morioka, S Renolleau, S Tan, S Vallabhapurapu, S W Tait, S Zelenay, SA Lakhani, SA Susin, SB Bratton, SC Chow, SJ Dixon, SJ Dixon, SJ Kim, SJ Martin, SJ Martin, SM Knoblach, SM Laster, SM Srinivasula, SN Willis, SW Tait, SW Tait, SW Tait, SW Tait, SW Tait, SW Yu, SW Yu, SY Chen, T Hirsch, T Ide, T Kaufmann, T Lindsten, T M Dawson, T Nakagawa, T Nakamura, T Panaretakis, T Rudel, T Tenev, T Vanden Berghe, T Vanden Berghe, T Vanden Berghe, T Vanden Berghe, T Vanden Berghe, TG Cotter, TJ Daish, TJ Fan, TM Caserta, U Moll, V De Laurenzi, V Giorgio, V Gogvadze, V L Dawson, V Labi, V M Dixit, V Nikoletopoulou, W Fiers, W G Wood, W Han, W Han, W Hou, W Malorni, W S El-Deiry, W Zhang, WJ Kaiser, WJ Kaiser, WS Yang, WW Chen, X Chen, X Li, X Liu, X Luo, X Pan, XM Yin, Y Ben-Neriah, Y Dondelinger, Y Dondelinger, Y Eguchi, Y Fuchs, Y Li, Y Liu, Y Rong, Y Shi, Y Tsujimoto, Y Wang, Y Zaltsman, YP Ow, YS Cho, Z Cai, Z Song, Z Wang, Z Zakeri, ZA Dunai   +438 more
core   +17 more sources

Targeting RIPK1 kinase for modulating inflammation in human diseases

Frontiers in Immunology, 2023
Receptor-Interacting Serine/Threonine-Protein Kinase 1 (RIPK1) is a master regulator of TNFR1 signaling in controlling cell death and survival. While the scaffold of RIPK1 participates in the canonical NF-κB pathway, the activation of RIPK1 kinase ...
Wanjin Li, Junying Yuan
doaj   +1 more source

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency [PDF]

, 2017
Apoptosis represents a key anti-cancer therapeutic effector mechanism. During apoptosis, mitochondrial outer membrane permeabilization (MOMP) typically kills cells even in the absence of caspase activity.
Albert, Matthew L., Blyth, Karen, Bock, Florian, Cao, Kai, Cloix, Catherine, Dhayade, Sandeep, Fort, Loic, Giampazolias, Evangelos, Ichim, Gabriel, Lecis, Daniele, Lopez, Jonathan, Machesky, Laura, Milling, Simon, Oberst, Andrew, Orozco, Susana, Peltzer, Nieves, Proïcs, Emma, Ricci, Jean-Ehrland, Roca, Alba, Rubio-Patiño, Camila, Ryan, Kevin M., Tait, Stephen W.G., Taraborrelli, Lucia, Walczak, Henning, Woodham, Emma, Yatim, Nader, Zunino, Barbara   +26 more
core   +2 more sources

ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner [PDF]

Cell Death & Differentiation, 2018
ABIN-1 (encoded by the gene Tnip1) is a ubiquitin-binding protein that can interact with ubiquitin-editing enzyme A20 (encoded by the gene TNFAIP3) to restrain the activation of necroptosis and NF-κB activation. Genetic variants in the genes Tnip1 and TNFAIP3 are both strongly associated with susceptibility to autoimmune chronic inflammatory diseases ...
Zhenyi Su, Slawomir A. Dziedzic, Die Hu, Vica Jean Barrett, Nicole Broekema, Wanjin Li, Lihui Qian, Na Jia, Dimitry Ofengeim, Ayaz Najafov, Hong Zhu, David M. Knipe, Junying Yuan   +12 more
openaire   +2 more sources

RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation [PDF]

, 2018
In this study, we took advantage of human-induced pluripotent stem cells (hiPSC) and CRISPR/Cas9 technology to investigate the potential roles of RIPK1 in regulating hematopoiesis and macrophage differentiation, proinflammatory activation, and cell death
Buchrieser, Julian, Cowley, Sally A., Long, Joshua C. D., Long, Joshua C. D., Moore, Michael D., Oliva Martín, María José, Pérez Simón, José Antonio, Venero Recio, José Luis   +7 more
core   +1 more source