Results 101 to 110 of about 17,129 (242)
Aging Cell, Volume 25, Issue 2, February 2026.This work proposes ferroptosis as a mechanistic driver of age‐related muscle dysfunction, whereby iron dyshomeostasis and impaired antioxidant capacity promote lipid peroxidation, and eventually trigger ferroptosis, leading to muscle wasting, and ultimately contributing to weakness and functional decline with aging.
Rola S. Zeidan +6 more
wiley +1 more source
RIPK3 mediates pathogenesis of experimental ventilator-induced lung injury [PDF]
JCI Insight, 2018 In patients requiring ventilator support, mechanical ventilation (MV) may induce acute lung injury (ventilator-induced lung injury [VILI]). VILI is associated with substantial morbidity and mortality in mechanically ventilated patients with and without acute respiratory distress syndrome. At the cellular level, VILI induces necrotic cell death. However,
Ilias I. Siempos +13 more
openaire +2 more sources
Necrostatin-1 Analogues: Critical Issues on the Specificity, Activity and In Vivo Use in Experimental Disease Models [PDF]
, 2012 Necrostatin-1 (Nec-1) is widely used in disease models to examine the contribution of receptor-interacting protein kinase (RIPK) 1 in cell death and inflammation.
Callewaert, N +15 more
core +2 more sources
Necroptosis induced by RIPK3 requires MLKL but not Drp1 [PDF]
Cell Death & Disease, 2014 Necroptosis is a mechanism by which cells can kill themselves that does not require caspase activity or the presence of the pro-apoptotic Bcl-2 family members Bax or Bak. It has been reported that RIPK3 (receptor interacting protein kinase 3) activates MLKL (mixed lineage kinase domain-like) to cause cell death that requires dynamin-related protein 1 ...
Moujalled, DM +3 more
openaire +3 more sources
Frontiers in Immunology, 2017 Fas-associated death domain (FADD) and receptor interacting protein kinase 3 (RIPK3) are multifunctional regulators of cell death and immune response. Using a mouse model of cryptococcal infection, the roles of FADD and RIPK3 in anti-cryptococcal defense
Zhenzong Fa +17 more
doaj +1 more source
Reformulating Pro-Oxidant Microglia in Neurodegeneration [PDF]
, 2019 In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered a new subpopulation named ...
Alonso Bellido, Isabel María +13 more
core +2 more sources
Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels
Advanced Science, Volume 13, Issue 1, 5 January 2026.A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu +10 more
wiley +1 more source
Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis
Disease Models & Mechanisms, 2020 Receptor-interacting protein kinase 3 (RIPK3) was recently implicated in promoting atherosclerosis progression through a proposed role in macrophage necroptosis.
Sarah Colijn +4 more
doaj +1 more source
Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL
Cell Death and Disease, 2021 RIPK3 was reported to play an important role in the protection against influenza A virus (IAV) in vivo. Here we show that the requirement of RIPK3 for protection against IAV infection in vivo is only apparent within a limited dose range of IAV challenge.
Teodora Oltean +7 more
doaj +1 more source
Role of necroptosis in the pathogenesis of solid organ injury [PDF]
, 2015 Necroptosis is a type of regulated cell death dependent on the activity of receptor-interacting serine/threonine-protein (RIP) kinases. However, unlike apoptosis, it is caspase independent.
Eguchi, S +5 more
core +1 more source