Results 131 to 140 of about 17,129 (242)

Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signaling

JCI Insight
Astrocyte activation is a common feature of neurodegenerative diseases. However, the ways in which dying neurons influence the activity of astrocytes is poorly understood. Receptor interacting protein kinase-3 (RIPK3) signaling has recently been described as a key regulator of neuroinflammation, but whether this kinase mediates astrocytic ...
Chang, Nydia P., DaPrano, Evan M., Lindman, Marissa, Estevez, Irving, Chou, Tsui-Wen, Evans, Wesley R., Nissenbaum, Marialaina, McCourt, Micheal, Alzate, Diego, Atkins, Colm, Kusnecov, Alexander W., Huda, Rafiq, Daniels, Brian P.   +12 more
openaire   +2 more sources

RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice

Cell Reports, 2017
RIPK3 mediates cell death and regulates inflammatory responses. Although genetic studies have suggested that RIPK3-MLKL-mediated necroptosis leads to embryonic lethality in Fadd or Caspase-8-deficient mice, the exact mechanisms are not fully understood ...
Qun Zhao, XianJun Yu, HaiWei Zhang, YongBo Liu, XiXi Zhang, XiaoXia Wu, Qun Xie, Ming Li, Hao Ying, Haibing Zhang   +9 more
doaj   +1 more source

Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis

Cell Reports, 2013
Caspase-8 or cellular FLICE-like inhibitor protein (cFLIP) deficiency leads to embryonic lethality in mice due to defects in endothelial tissues. Caspase-8−/− and receptor-interacting protein kinase-3 (RIPK3)−/−, but not cFLIP−/− and RIPK3−/−, double ...
Ricardo Weinlich, Andrew Oberst, Christopher P. Dillon, Laura J. Janke, Sandra Milasta, John R. Lukens, Diego A. Rodriguez, Prajwal Gurung, Chandra Savage, Thirumala D. Kanneganti, Douglas R. Green   +10 more
doaj   +1 more source

RIPK3 promotes islet amyloid-induced β-cell loss and glucose intolerance in a humanized mouse model of type 2 diabetes

Molecular Metabolism
Objective: Aggregation of human islet amyloid polypeptide (hIAPP), a β-cell secretory product, leads to islet amyloid deposition, islet inflammation and β-cell loss in type 2 diabetes (T2D), but the mechanisms that underlie this process are incompletely ...
Noyonika Mukherjee, Christopher J. Contreras, Li Lin, Kaitlyn A. Colglazier, Egan G. Mather, Michael A. Kalwat, Nathalie Esser, Steven E. Kahn, Andrew T. Templin   +8 more
doaj   +1 more source

Fig. S3 from Absence of Either <i>Ripk3</i> or <i>Mlkl</i> Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis

, 2023
Sabira Mohammed, Nidheesh Thadathil, Phoebe Ohene-Marfo, Albert L. Tran, Michael Van Der Veldt, Constantin Georgescu, Sangphil Oh, Evan H. Nicklas, Dawei Wang, Nair Hariprasad Haritha, Wenyi Luo, Ralf Janknecht, Benjamin F. Miller, Jonathan D. Wren, Willard M. Freeman, Sathyaseelan S. Deepa   +15 more
openalex   +1 more source

The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair [PDF]

, 2014
Kenta Moriwaki, Sakthi Balaji, Thomas J. McQuade, Deepali Malhotra, Joonsoo Kang, Francis K.L. Chan   +5 more
openalex   +1 more source

Influence of transplantation of neural stem cells on the expression of genes involved in the programmed cell death following ischemic brain stroke [PDF]

, 2019
Ishemijski moždani udar, te posljedične tkivna hipoksija i ishemija, uzrokuju značajno oštećenje moždanog tkiva. Jedan od pristupa u potrazi za pronalaskom uspješne obnove oštećenog tkiva uključuje primjenu matičnih stanica.
Hribljan, Valentina
core   +1 more source

Nucleic acid sensors and programmed cell death [PDF]

, 2020
Liverpool, Layal, Maelfait, Jonathan, Rehwinkel, Jan   +2 more
core   +2 more sources

Structure-based design of potent and selective inhibitors targeting RIPK3 for eliminating on-target toxicity in vitro

Nature Communications
The essential role of RIPK3 in necroptosis makes its inhibition a promising therapeutic strategy. However, the development of RIPK3 inhibitors has been hampered by on-target apoptosis and limited kinase selectivity.
Haixia Su, Guofeng Chen, Hang Xie, Wanchen Li, Muya Xiong, Jian He, Hangchen Hu, Wenfeng Zhao, Qiang Shao, Minjun Li, Qiang Zhao, Yechun Xu   +11 more
doaj   +1 more source

The Role of RIPK1 and RIPK3 in Cardiovascular Disease [PDF]

, 2020
Elise DeRoo, Ting Zhou, Bo Liu
openalex   +1 more source