Results 21 to 30 of about 19,353 (245)

Quercetin'in HT-29 ve HCT-116 kolon kanseri hücre hatları üzerine etkisinin RIPK1, RIPK3 ve MLKL genlerinin ekspresyonları ile incelenmesi

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, 2023
Amaç: Quercetin kolon kanseri dahil birçok kanser çeşidinde anti-kanser aktivite gösteren bir bileşiktir. Ancak, quercetinin nekroptoz yolağı üzerine etkilerini gösteren çalışmalar kısıtlıdır ve bu nedenle bu çalışmada quercetinin nekroptoz yolağına ...
Haydar Bağış, Esra Bozgeyik, Alp Can Tuncer, Sevval Has   +3 more
doaj   +1 more source

Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis [PDF]

Nature Communications, 2016
AbstractCrystals cause injury in numerous disorders, and induce inflammation via the NLRP3 inflammasome, however, it remains unclear how crystals induce cell death. Here we report that crystals of calcium oxalate, monosodium urate, calcium pyrophosphate dihydrate and cystine trigger caspase-independent cell death in five different cell types, which is ...
et al,, Liapis, Helen
core   +8 more sources

Necroptosis in Pulmonary Diseases: A New Therapeutic Target

Frontiers in Pharmacology, 2021
In the past decades, apoptosis has been the most well-studied regulated cell death (RCD) that has essential functions in tissue homeostasis throughout life.
Lingling Wang, Ling Zhou, Yuhao Zhou, Lu Liu, Weiling Jiang, Huojun Zhang, Huiguo Liu   +6 more
doaj   +1 more source

Execution of RIPK3-regulated necrosis [PDF]

Molecular & Cellular Oncology, 2014
Necroptosis is a form of regulated necrotic cell death that is mediated by receptor-interacting protein 1 (RIP1) and RIP3 kinases. Diverse receptors, including death receptors, Toll-like receptors, interferon receptors, and DAI DNA receptors are able to trigger necroptosis.
Cai, Zhenyu, Liu, Zheng-Gang
openaire   +2 more sources

Cpd-42 protects against calcium oxalate nephrocalcinosis-induced renal injury and inflammation by targeting RIPK3-mediated necroptosis

Frontiers in Pharmacology, 2022
Calcium oxalate (CaOx) crystals, as the predominant component of human kidney stones, can trigger excessive cell death and inflammation of renal tubular epithelial cells, involved in the pathogenesis of nephrocalcinosis.
Bingbing Hou, Bingbing Hou, Bingbing Hou, Mingming Liu, Yang Chen, Yang Chen, Yang Chen, Weijian Ni, Xiaoguo Suo, Yuexian Xu, Yuexian Xu, Yuexian Xu, Qiushi He, Qiushi He, Qiushi He, Xiaoming Meng, Zongyao Hao, Zongyao Hao, Zongyao Hao   +18 more
doaj   +1 more source

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]

, 2020
Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien, de Reuver, Richard, Declercq, Wim, Devos, Michael, Dierick, Evelien, Gilbert, Barbara, Lefebvre, Sylvie, Maelfait, Jonathan, Nemegeer, Josephine, Rehwinkel, Jan, Tanghe, Giel, Vandenabeele, Peter, Verheirstraeten, Maud   +12 more
core   +2 more sources

Macrophage-derived galectin-3 contributes to pyroptosis, apoptosis and necroptosis through TLR4/MyD88/NF-κB/NLRP3 during atherosclerosis. [PDF]

Clin Transl Med
Pyroptosis, apoptosis and necroptosis of macrophages occur concurrently during atherosclerosis. Galetein‐3 and NLRP3 are highly expressed in atherosclerotic lesions. Galectin‐3 is principally expressed in macrophages within atherosclerotic plaques. Galectin‐3 interacts with NLRP3, activates TLR4/MyD88/NF‐κB/NLRP3 signal axis, and promotes PANoptosis ...
Yuan Z, Li H, Ruan BX, Huang H, Li Y, Wang J.   +5 more
europepmc   +2 more sources

RIPK3 promotes adenovirus type 5 activity [PDF]

Cell Death & Disease, 2017
AbstractOncolytic adenoviral mutants infect human malignant cells and replicate selectively within them. This induces direct cytotoxicity that can also trigger profound innate and adaptive immune responses. However, the mechanism by which adenoviruses produce cell death remains uncertain.
Melanie Weigert, Alex Binks, Suzanne Dowson, Elaine Y. L. Leung, Dimitris Athineos, Xinzi Yu, Margaret Mullin, Josephine B. Walton, Clare Orange, Darren Ennis, Karen Blyth, Stephen W. G. Tait, Iain A. McNeish   +12 more
openaire   +5 more sources

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation [PDF]

, 2020
Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammatory responses downstream of TNFR1 and other receptors, and has been implicated in the pathogenesis of inflammatory and degenerative diseases.
Bertrand, Mathieu, Corona, Teresa, Delanghe, Tom, Kondylis, Vangelis, Krüger, Marcus, Kumari, Snehlata, Laurien, Lucie, Nagata, Masahiro, Pasparakis, Manolis, Schwarzer, Robin, Schünke, Hannah, Wiederstein, Janica L.   +11 more
core   +1 more source

Primary cilia suppress Ripk3-mediated necroptosis

Cell Death Discovery, 2022
AbstractCilia are sensory organelles that project from the surface of almost all cells. Nephronophthisis (NPH) and NPH-related ciliopathies are degenerative genetic diseases caused by mutation of cilia-associated genes. These kidney disorders are characterized by progressive loss of functional tubular epithelial cells which is associated with ...
Emilia Kieckhöfer, Gisela G. Slaats, Lena K. Ebert, Marie-Christine Albert, Claudia Dafinger, Hamid Kashkar, Thomas Benzing, Bernhard Schermer   +7 more
openaire   +4 more sources