Results 21 to 30 of about 17,129 (242)

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Execution of RIPK3-regulated necrosis [PDF]

Molecular & Cellular Oncology, 2014
Necroptosis is a form of regulated necrotic cell death that is mediated by receptor-interacting protein 1 (RIP1) and RIP3 kinases. Diverse receptors, including death receptors, Toll-like receptors, interferon receptors, and DAI DNA receptors are able to trigger necroptosis.
Cai, Zhenyu, Liu, Zheng-Gang
openaire   +2 more sources

Quercetin'in HT-29 ve HCT-116 kolon kanseri hücre hatları üzerine etkisinin RIPK1, RIPK3 ve MLKL genlerinin ekspresyonları ile incelenmesi

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, 2023
Amaç: Quercetin kolon kanseri dahil birçok kanser çeşidinde anti-kanser aktivite gösteren bir bileşiktir. Ancak, quercetinin nekroptoz yolağı üzerine etkilerini gösteren çalışmalar kısıtlıdır ve bu nedenle bu çalışmada quercetinin nekroptoz yolağına ...
Haydar Bağış, Esra Bozgeyik, Alp Can Tuncer, Sevval Has   +3 more
doaj   +1 more source

Induced necroptosis limits <i>Toxoplasma gondii</i> replication in a RIPK3/MLKL-dependent manner. [PDF]

Infect Immun
Erazo BJ, Knoll LJ.
europepmc   +2 more sources

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]

, 2020
Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien, de Reuver, Richard, Declercq, Wim, Devos, Michael, Dierick, Evelien, Gilbert, Barbara, Lefebvre, Sylvie, Maelfait, Jonathan, Nemegeer, Josephine, Rehwinkel, Jan, Tanghe, Giel, Vandenabeele, Peter, Verheirstraeten, Maud   +12 more
core   +2 more sources

RIPK3 promotes adenovirus type 5 activity [PDF]

Cell Death & Disease, 2017
AbstractOncolytic adenoviral mutants infect human malignant cells and replicate selectively within them. This induces direct cytotoxicity that can also trigger profound innate and adaptive immune responses. However, the mechanism by which adenoviruses produce cell death remains uncertain.
Melanie Weigert, Alex Binks, Suzanne Dowson, Elaine Y. L. Leung, Dimitris Athineos, Xinzi Yu, Margaret Mullin, Josephine B. Walton, Clare Orange, Darren Ennis, Karen Blyth, Stephen W. G. Tait, Iain A. McNeish   +12 more
openaire   +5 more sources

Primary cilia suppress Ripk3-mediated necroptosis

Cell Death Discovery, 2022
AbstractCilia are sensory organelles that project from the surface of almost all cells. Nephronophthisis (NPH) and NPH-related ciliopathies are degenerative genetic diseases caused by mutation of cilia-associated genes. These kidney disorders are characterized by progressive loss of functional tubular epithelial cells which is associated with ...
Emilia Kieckhöfer, Gisela G. Slaats, Lena K. Ebert, Marie-Christine Albert, Claudia Dafinger, Hamid Kashkar, Thomas Benzing, Bernhard Schermer   +7 more
openaire   +4 more sources

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation [PDF]

, 2020
Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammatory responses downstream of TNFR1 and other receptors, and has been implicated in the pathogenesis of inflammatory and degenerative diseases.
Bertrand, Mathieu, Corona, Teresa, Delanghe, Tom, Kondylis, Vangelis, Krüger, Marcus, Kumari, Snehlata, Laurien, Lucie, Nagata, Masahiro, Pasparakis, Manolis, Schwarzer, Robin, Schünke, Hannah, Wiederstein, Janica L.   +11 more
core   +1 more source

Killing AML: RIPK3 leads the way [PDF]

Cell Cycle, 2016
Acute myeloid leukemia (AML) is a heterogeneous group of haematopoietic neoplasms driven partly by the loss of differentiation and the blockade of cell death.
Ulrike, Höckendorf, Monica, Yabal, Philipp J, Jost   +2 more
openaire   +2 more sources

A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2α-induced corpus luteum regression

eLife, 2021
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) normally signals to necroptosis by phosphorylating MLKL. We report here that when the cellular RIPK3 chaperone Hsp90/CDC37 level is low, RIPK3 also signals to apoptosis.
Dianrong Li, Jie Chen, Jia Guo, Lin Li, Gaihong Cai, She Chen, Jia Huang, Hui Yang, Yinhua Zhuang, Fengchao Wang, Xiaodong Wang   +10 more
doaj   +1 more source