Results 31 to 40 of about 17,129 (242)
Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells [PDF]
, 2012 For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also occur in a regulated manner.
Barna, Gabor +6 more
core +9 more sources
Preventing necroptosis by scavenging ROS production alleviates heat stress-induced intestinal injury
International Journal of Hyperthermia, 2020 Background Worldwide heat stroke incidence has increased in recent years and is associated with high morbidity and mortality. Therefore, it is critical to identify mechanisms that mediate heat stroke.
Li Li +9 more
doaj +1 more source
Endothelial MLKL Inhibition Reduces Hyperoxia-Induced Bronchopulmonary Dysplasia in Neonatal Mice. [PDF]
J Cell Mol MedABSTRACT Bronchopulmonary dysplasia (BPD) remains a severe complication in premature infants requiring prolonged oxygen therapy, with vascular endothelial dysfunction recognised as a critical contributor to disease progression. Mixed lineage kinase domain‐like protein (MLKL)‐mediated necroptosis, an essential form of regulated cell death implicated in ...
Ning J, Deng J, Sang Y, Qiao L.
europepmc +2 more sources
RIPK3 modulates sarcoma through immune checkpoint HAVCR2
Oncology Letters, 2022 Sarcomas is a complex group of malignant diseasse with undetermined molecular mechanisms. Receptor interacting serine/threonine kinase 3 (RIPK3) is a necroptosis- and apoptosis-related marker that has been implicated in several immune-associated diseases and aggressive malignant tumours. In the present study, publicly available transcriptome sequencing
Qian, Chen, Wu, Deluo, Du, Jianwei
openaire +2 more sources
RIPK3: A New Player in Renal Fibrosis [PDF]
Frontiers in Cell and Developmental Biology, 2020 Chronic kidney disease (CKD) is the end result of a plethora of renal insults, including repeated episodes of acute or toxic kidney injury, glomerular, or diabetic kidney disease. It affects a large number of the population worldwide, resulting in significant personal morbidity and mortality and economic cost to the community.
Ying Shi +3 more
openaire +3 more sources
Cell Death Discovery, 2022 Neutrophils are important effector cells during inflammation, which play complex roles. Therefore, investigating the regulation of neutrophil accumulation during inflammation might provide targets for treating related diseases.
Wanying Wen +4 more
doaj +1 more source
Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis. [PDF]
, 2018 Understanding the molecular signaling in programmed cell death is vital to a practical understanding of inflammation and immune cell function. Here we identify a previously unrecognized mechanism that functions to downregulate the necrosome, a central ...
A Degterev +67 more
core +2 more sources
Sugar Fix Keeps RIPK3 at Bay [PDF]
Immunity, 2019 Immunometabolism is emerging as an important modulator of immune responses. In this issue of Immunity, Li et al. (2019) examine the link between lipopolysaccharide (LPS)-induced glucose metabolism and innate immune signaling and identify how β-N-acetylglucosamine (O-GlcNAc) modification of the RIPK3 RHIM domain limits inflammation and necroptosis.
Cristina, Giogha, Kate E, Lawlor
openaire +2 more sources
Cytoplasmic MYC is an anti-necroptotic protein
Molecular & Cellular Oncology, 2020 Cancer cells are often resistant to necroptosis as well as apotosis, but the underlying mechanisms are not fully understood. We recently revealed an important crosstalk between MYC, a potent oncogene, and receptor-interacting protein kinase 3 (RIPK3), a ...
Eun-Woo Lee +2 more
doaj +1 more source
RIPK3 Takes Another Deadly Turn [PDF]
Science, 2014 Blocking an enzyme involved in necroptosis may prove toxic by promoting another form of cell death. [Also see Report by Newton et al. ]
Jianke Zhang, Francis Ka-Ming Chan
openaire +1 more source