Results 61 to 70 of about 17,129 (242)

Mechanisms of TNF-independent RIPK3-mediated cell death

Biochemical Journal, 2022
Apoptosis and necroptosis regulate many aspects of organismal biology and are involved in various human diseases. TNF is well known to induce both of these forms of cell death and the underlying mechanisms have been elaborately described. However, cells can also engage apoptosis and necroptosis through TNF-independent mechanisms, involving, for example,
Bart Tummers, Douglas R. Green
openaire   +2 more sources

RIPK3 promoter hypermethylation in hepatocytes protects from bile acid-induced inflammation and necroptosis

Cell Death and Disease, 2023
Necroptosis facilitates cell death in a controlled manner and is employed by many cell types following injury. It plays a significant role in various liver diseases, albeit the cell-type-specific regulation of necroptosis in the liver and especially ...
Jessica Hoff, Ling Xiong, Tobias Kammann, Sophie Neugebauer, Julia M. Micheel, Nikolaus Gaßler, Michael Bauer, Adrian T. Press   +7 more
doaj   +1 more source

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF [PDF]

, 2019
The ubiquitin-editing enzyme A20 is a well-known regulator of immune cell function and homeostasis. In addition, A20 protects cells from death in an ill-defined manner.
Boon, Louis, De Prijck, Sofie, Deswarte, Kim, Fayazpour, Farzaneh, Janssens, Sophie, Lambrecht, Bart, Martens, Arne, Takahashi, Nozomi, Tavernier, Simon, van Helden, Mary, van Loo, Geert, Van Moorleghem, Justine, Vandenabeele, Peter, Vanheerswynghels, Manon, Vergote, Karl, Vetters, Jessica, Vivier, Eric, Wahlen, Sigrid   +17 more
core   +6 more sources

PLK1-mediated S369 phosphorylation of RIPK3 during G2 and M phases enables its ripoptosome incorporation and activity

iScience, 2021
Summary: Receptor-interacting protein kinase 3 executes a form of regulated necrosis called necroptosis. Upon induction of an altered conformation by chemical inhibitors or via mutations in its kinase site, RIPK3 associates with a multiprotein complex ...
Kartik Gupta, Bo Liu
doaj   +1 more source

Ca2+/Calmodulin-Dependent Protein Kinase II Regulation by RIPK3 Alleviates Necroptosis in Transverse Arch Constriction-Induced Heart Failure

Frontiers in Cardiovascular Medicine, 2022
Some studies have reported that the activation of Ca2+/calmodulin dependent protein kinase (CaMKII) plays a vital role in the pathogenesis of cardiovascular disease.
Ji Cao, Jingjing Zhang, Jingjing Zhang, Jianan Qian, Xue Wang, Wei Zhang, Wei Zhang, Xiangfan Chen   +7 more
doaj   +1 more source

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

RIPK3-Mediated Necroptosis Regulates Cardiac Allograft Rejection

American Journal of Transplantation, 2014
Cell death results in tissue damage and ultimately donor graft rejection and can occur as an active molecular process through apoptotic, necrotic and newly identified receptor interacting protein 1 and 3 kinase (RIPK1/3)-mediated necroptotic pathways. Necroptosis leads to the release of inflammatory molecules which can activate host immune cells.
A, Pavlosky, A, Lau, Y, Su, D, Lian, X, Huang, Z, Yin, A, Haig, A M, Jevnikar, Z-X, Zhang   +8 more
openaire   +2 more sources

Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signaling

, 2023
AbstractAstrocyte activation is a common feature of neurodegenerative diseases. However, the ways in which dying neurons influence the activity of astrocytes is poorly understood. RIPK3 signaling has recently been described as a key regulator of neuroinflammation, but whether this kinase mediates astrocytic responsiveness to neuronal death has not yet ...
Nydia P. Chang, Evan M. DaPrano, Wesley R. Evans, Marialaina Nissenbaum, Micheal McCourt, Diego Alzate, Marissa Lindman, Tsui-Wen Chou, Colm Atkins, Alexander W. Kusnecov, Rafiq Huda, Brian P. Daniels   +11 more
openaire   +2 more sources

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

Nature Communications, 2021
The pseudokinase MLKL is activated by the upstream kinase RIPK3 in the necroptotic pathway but the structural basis of MLKL activation is not well understood yet.
Yanxiang Meng, Katherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Christopher R. Horne, Cindy Luo, Jean-Marc Garnier, Lung-Yu Liang, Angus D. Cowan, Andre L. Samson, Guillaume Lessene, Jarrod J. Sandow, Peter E. Czabotar, James M. Murphy   +14 more
doaj   +1 more source

RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation [PDF]

, 2018
In this study, we took advantage of human-induced pluripotent stem cells (hiPSC) and CRISPR/Cas9 technology to investigate the potential roles of RIPK1 in regulating hematopoiesis and macrophage differentiation, proinflammatory activation, and cell death
Buchrieser, Julian, Cowley, Sally A., Long, Joshua C. D., Long, Joshua C. D., Moore, Michael D., Oliva Martín, María José, Pérez Simón, José Antonio, Venero Recio, José Luis   +7 more
core   +1 more source