Results 161 to 170 of about 654 (199)

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

PRMT5 regulates RNA m6A demethylation for doxorubicin sensitivity in breast cancer

Molecular Therapy, 2022
Cancer cells respond to various stressful conditions through the dynamic regulation of RNA m6A modification. Doxorubicin is a widely used chemotherapeutic drug that induces DNA damage. It is interesting to know whether cancer cells regulate the DNA damage response and doxorubicin sensitivity through RNA m6A modification. Here, we found that doxorubicin
Ceshi Chen, Changhong Shi
exaly   +3 more sources

The chemistries and consequences of DNA and RNA methylation and demethylation [PDF]

RNA Biology, 2017
Chemical modification of nucleobases plays an important role for the control of gene expression on different levels. That includes the modulation of translation by modified tRNA-bases or silencing and reactivation of genes by methylation and demethylation of cytosine in promoter regions.
Thomas Carell, Franziska Traube
exaly   +3 more sources

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ALKBH1 promotes lung cancer by regulating m6A RNA demethylation

Biochemical Pharmacology, 2021
Lung cancer has surpassed breast cancer as the leading cause of cancer death in females in developed countries and the leading cause of cancer death in males. Despite extensive research on lung cancer, the pathogenesis of lung cancer is not fully understood.
Hong Li, Ying Zhang, Yajuan Guo, Rong Liu, Qi Yu, Lingzhi Gong, Zhongqiu Liu, Wei Xie, Caiyan Wang   +8 more
openaire   +2 more sources

ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing

Nature Cell Biology, 2021
Members of the mammalian AlkB family are known to mediate nucleic acid demethylation1,2. ALKBH7, a mammalian AlkB homologue, localizes in mitochondria and affects metabolism3, but its function and mechanism of action are unknown. Here we report an approach to site-specifically detect N1-methyladenosine (m1A), N3-methylcytidine (m3C), N1-methylguanosine
Li-Sheng Zhang, Qing-Ping Xiong, Sonia Peña Perez, Chang Liu, Jiangbo Wei, Cassy Le, Linda Zhang, Bryan T. Harada, Qing Dai, Xinran Feng, Ziyang Hao, Yuru Wang, Xueyang Dong, Lulu Hu, En-Duo Wang, Tao Pan, Arne Klungland, Ru-Juan Liu, Chuan He   +18 more
openaire   +3 more sources

RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis

Developmental Cell, 2021
Adenosine N6-methylation (m6A) is one of the most pervasive mRNA modifications, and yet the physiological significance of m6A removal (demethylation) remains elusive. Here, we report that the m6A demethylase FTO functions as a conserved regulator of motile ciliogenesis.
Hyunjoon Kim, Tae-Don Kim, Young-Suk Lee   +2 more
exaly   +3 more sources

ROS3 is an RNA-binding protein required for DNA demethylation in Arabidopsis [PDF]

Nature, 2008
DNA methylation is an important epigenetic mark for transcriptional gene silencing (TGS) in diverse organisms. Recent studies suggest that the methylation status of a number of genes is dynamically regulated by methylation and demethylation. In Arabidopsis, active DNA demethylation is mediated by the ROS1 (repressor of silencing 1) subfamily of 5 ...
Jian-Kang Zhu, Daisuke Miki, Craig Pikaard   +2 more
exaly   +3 more sources

Programmable RNA methylation and demethylation using PUF RNA binding proteins

Chemical Communications, 2020
A new method manipulating local RNA methylation was developed by fusing the programmable RNA binding protein and the m 6 A demethylase or methyltransferase.
Kouki Shinoda, Akiyo Suda, Kenko Otonari, Shiroh Futaki, Miki Imanishi   +4 more
openaire   +2 more sources

Non-coding RNA directed DNA demethylation of Sphk1 CpG island

Biochemical and Biophysical Research Communications, 2004
The formation of DNA methylation patterns is one of the epigenetic events that underlie mammalian development. The Sphk1 CpG island is a target for tissue-dependent DNA methylation as well as a template for generating multiple subtypes. The number of mammalian non-coding RNA genes is rapidly expanding.
Takuya Imamura, Jun Ohgane, Kunio Shiota   +2 more
exaly   +3 more sources

Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2019
FTO demethylates internal N 6 -methyladenosine (m 6 A) and N 6 ,2′- O -dimethyladenosine (m 6
Yu Xiao, Guifang Jia, Liang Zhang
exaly   +3 more sources