Results 171 to 180 of about 654 (199)

RNA m6A regulates transcription via DNA demethylation and chromatin accessibility

Nature Genetics, 2022
Transcriptional regulation, which integrates chromatin accessibility, transcription factors and epigenetic modifications, is crucial for establishing and maintaining cell identity. The interplay between different epigenetic modifications and its contribution to transcriptional regulation remains elusive.
Shuang Deng, Jialiang Zhang, Jiachun Su, Zhixiang Zuo, Lingxing Zeng, Kaijing Liu, Yanfen Zheng, Xudong Huang, Ruihong Bai, Lisha Zhuang, Ying Ye, Mei Li, Ling Pan, Junge Deng, Guandi Wu, Rui Li, Shaoping Zhang, Chen Wu, Dongxin Lin, Jianjun Chen, Jian Zheng   +20 more
openaire   +2 more sources

Demethylation of ribosomal RNA by hepatocyte microsomal preparations

Life Sciences, 1991
Previous work has shown that hypomethylation of rRNA is an important control for protein synthesis in rat hepatocytes, and that the net hypomethylation appears to arise from cytoplasmic events. Here we show that demethylation of rRNA is catalyzed by microsomal preparations.
W T, Choe, C L, Hatem, G A, Clawson
openaire   +2 more sources

Repair of methyl lesions in DNA and RNA by oxidative demethylation

Neuroscience, 2007
It was established several decades ago that it is crucial for all organisms to repair their DNA to maintain genome integrity and numerous proteins are dedicated to this purpose. However, it is becoming increasingly clear that it is also important to prevent and repair lesions in the macromolecules encoded by the DNA, i.e. RNA and protein.
P Ø, Falnes, A, Klungland, I, Alseth
openaire   +2 more sources

Repair of methyl lesions in RNA by oxidative demethylation

MedChemComm, 2014
Nucleic acid methylation is one of the most important epigenetic modifications that have been studied intensively for the past several decades.
Fei Ye, Liyi Zhang, Lu Jin, Mingyue Zheng, Hualiang Jiang, Cheng Luo   +5 more
openaire   +1 more source

RNA Demethylation by FTO and ALKBH5

2015
RNA plays a central role in the flow of genetic information in the central dogma. Over 100 structurally distinct post-transcriptional modifications have been identified in RNA, yet little is known about the functions of most of these modifications. N6-methyladenosine (m6A) is one of the most intriguing RNA modifications and is also the most abundant ...
Guanqun Zheng, Chuan He
openaire   +1 more source

Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage [PDF]

EMBO Journal, 2006
Methylating agents are ubiquitous in the environment, and central in cancer therapy. The 1-methyladenine and 3-methylcytosine lesions in DNA/RNA contribute to the cytotoxicity of such agents. These lesions are directly reversed by ABH3 (hABH3) in humans and AlkB in Escherichia coli.
Finn Drabløs, Magnar Bjørås, Mirta Mittelstedt Leal DE SOUSA   +2 more
exaly   +3 more sources

RNA demethylation increases the yield and biomass of rice and potato plants in field trials

Nature Biotechnology, 2021
RNA N6-methyladenosine (m6A) modifications are essential in plants. Here, we show that transgenic expression of the human RNA demethylase FTO in rice caused a more than threefold increase in grain yield under greenhouse conditions. In field trials, transgenic expression of FTO in rice and potato caused ~50% increases in yield and biomass.
Qiong Yu, Shun Liu, Lu Yu, Yu Xiao, Shasha Zhang, Xueping Wang, Yingying Xu, Hong Yu, Yulong Li, Junbo Yang, Jun Tang, Hong-Chao Duan, Lian-Huan Wei, Haiyan Zhang, Jiangbo Wei, Qian Tang, Chunling Wang, Wutong Zhang, Ye Wang, Peizhe Song, Qiang Lu, Wei Zhang, Shunqing Dong, Baoan Song, Chuan He, Guifang Jia   +25 more
openaire   +2 more sources

Programmable RNA N¹‐Methyladenosine Demethylation by a Cas13d‐Directed Demethylase

Angewandte Chemie International Edition, 2021
AbstractN1‐methyladenosine (m1A) is a prevalent and reversible RNA modification, which plays a crucial role in the regulation of RNA fate and gene expression. However, the lack of tools to precisely manipulate m1A sites in specific transcripts has hindered efforts to clarify the association between a specific m1A‐modified transcript and its phenotypic ...
Shanshan Xie, Hao Jin, Feng Yang, Hong Zheng, Yongxia Chang, Ying Liao, Ye Zhang, Tianhua Zhou, Yang Li   +8 more
openaire   +2 more sources

Human DNA-demethylating activity: A glycosylase associated with RNA and PCNA

Journal of Cellular Biochemistry, 2000
We have partially purified and characterized the 5-methylcytosine removing activity (5-meC-DNA Glycosylase) from HeLa cells with 700-fold enrichment. This activity cleaves DNA specifically at fully methylated CpG sites. The mechanism of 5-meC removal is base excision from fully methylated CpG loci on DNA, producing abasic sites.
M, Vairapandi, D A, Liebermann, B, Hoffman, N J, Duker   +3 more
openaire   +2 more sources

Intrapericardial long non-coding RNA– Tcf21 antisense RNA inducing demethylation administration promotes cardiac repair

European Heart Journal, 2023
Abstract Aims Epicardium and epicardium-derived cells are critical players in myocardial fibrosis. Mesenchymal stem cell–derived extracellular vesicles (EVs) have been studied for cardiac repair to improve cardiac remodelling, but the actual mechanisms remain elusive.
Li, Zhenhua, Liu, Shuo, Huang, Ke, Mei, Xuan, Cheng, Ke, Zhu, Dashuai, Li, Junlang   +6 more
openaire   +2 more sources