Results 21 to 30 of about 238,840 (242)
meRanTK: methylated RNA analysis ToolKit [PDF]
Bioinformatics, 2015 Abstract Summary: The significance and function of posttranscriptional cytosine methylation in poly(A)RNA attracts great interest but is still poorly understood. High-throughput sequencing of RNA treated with bisulfite (RNA-BSseq) or subjected to enrichment techniques like Aza-IP or miCLIP enables transcriptome wide studies of this ...
Dietmar, Rieder +4 more
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MedComm – Future Medicine, 2023 RNA methylation plays a key role across biological processes, which could be utilized as new weapons for cancer management. However, the implication of RNA methylation regulators in cancers, especially in clear cell renal cell cancer (ccRCC), remains ...
Aimin Jiang +12 more
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WIREs RNA, 2021 AbstractAmong RNA modifications, transfer of methylgroups from the typical cofactor S‐adenosyl‐l‐methionine by methyltransferases (MTases) to RNA is by far the most common reaction. Since our last review about a decade ago, the field has witnessed the re‐emergence of mRNA methylation as an important mechanism in gene regulation.
Yuri Motorin, Mark Helm
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RNA Methylation Clears the Way [PDF]
Developmental Cell, 2017 During the maternal-to-zygotic transition, maternal mRNAs are cleared by multiple distinct but interrelated pathways. A recent study in Nature by Zhao et al. (2017) finds that YTHDF2, a reader of N6- methylation, facilitates maternal mRNA decay, introducing an additional facet of control over transcript fate and developmental reprogramming.
Cassandra, Kontur, Antonio, Giraldez
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Emerging roles of RNA methylation in gastrointestinal cancers
Cancer Cell International, 2020 RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associated with human cancer progression ...
Shanshan Xie +8 more
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The role of RNA m6A methylation in lipid metabolism
Frontiers in Endocrinology, 2022 The m6A methylation is the most numerous modification of mRNA in mammals, coordinated by RNA m6A methyltransferases, RNA m6A demethylases, and RNA m6A binding proteins. They change the RNA m6A methylation level in their specific manner.
Yuting Wang +5 more
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2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase. [PDF]
PLoS Pathogens, 2012 RNA modification plays an important role in modulating host-pathogen interaction. Flavivirus NS5 protein encodes N-7 and 2'-O methyltransferase activities that are required for the formation of 5' type I cap (m(7)GpppAm) of viral RNA genome.
Hongping Dong +10 more
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RNA‐Cleaving Deoxyribozymes Differentiate Methylated Cytidine Isomers in RNA
Angewandte Chemie International Edition, 2021 AbstractDeoxyribozymes are emerging as modification‐specific endonucleases for the analysis of epigenetic RNA modifications. Here, we report RNA‐cleaving deoxyribozymes that differentially respond to the presence of natural methylated cytidines, 3‐methylcytidine (m3C), N4‐methylcytidine (m4C), and 5‐methylcytidine (m5C), respectively.
Anam Liaqat +3 more
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Myo1e overexpression in lung adenocarcinoma is associated with increased risk of mortality
Scientific Reports, 2023 This study aims to perform a comprehensive genomic analysis to assess the influence of overexpression of MYO1E in non-small cell lung carcinoma (NSCLC) and whether there are differences in survival and mortality risk in NSCLC patients depending on both ...
Ignacio Jusue-Torres +21 more
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Journal of Inflammation Research, 2022 Xin-Yu Li,1,2 Xi-Tao Yang1 1Department of Interventional Therapy, Multidisciplinary Team of Vascular Anomalies, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Department of Neurosurgery, Shanghai ...
Li XY, Yang XT
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