Results 71 to 80 of about 774,970 (276)

A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS. [PDF]

, 2019
Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily on ribosomal RNA (rRNA).
Blanchard, Scott C, Calvert, Meredith E, Chen, Bin, Contreras, Adrian, Forester, Craig M, Gill, Ryan M, Gordan, John D, Holm, Mikael, Jackson, Cody, Kelley, R Kate, Luk, John M, McMahon, Mary, Pang, Xiaming, Quigley, David A, Ruggero, Davide, Uechi, Tamayo   +15 more
core   +1 more source

A complex adaptive systems approach to the kinetic folding of RNA

, 2005
The kinetic folding of RNA sequences into secondary structures is modeled as a complex adaptive system, the components of which are possible RNA structural rearrangements (SRs) and their associated bases and base pairs. RNA bases and base pairs engage in
Abrahams, Baker, Cannone, Fisher, Flamm, Fontana, Freier, Gratias, Gultyaev, Hadany, Higgs, Hofacker, Isambert, Kauffman, Kauffman, Kawasaki, Lee, Levin, Mathews, Mathews, McCarthy, Metropolis, Mironov, Mochizuki, Morgan, Nagel, Ndifon, Poerschke, Poerschke, Schuster, Schuster, Schuster, Skellett, Tang, Vitreschack, Wilfred Ndifon, Woese, Wolfinger, Xayaphoummine, Yang, Zamora, Zhang   +41 more
core   +3 more sources

RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis. [PDF]

, 2018
Small RNAs regulate chromatin modifications such as DNA methylation and gene silencing across eukaryotic genomes. In plants, RNA-directed DNA methylation (RdDM) requires 24-nucleotide small interfering RNAs (siRNAs) that bind to ARGONAUTE 4 (AGO4) and ...
Chory, Joanne, Duttke, Sascha H, Feng, Suhua, Gallego-Bartolome, Javier, Groth, Martin, Hetzel, Jonathan, Jacobsen, Steven E, Kuo, Hsuan Yu, Liu, Wanlu, Wang, Zonghua, Zhai, Jixian, Zhong, Zhenhui   +11 more
core   +1 more source

RNA modification in Cajal bodies [PDF]

RNA Biology, 2016
Aside from nucleoli, Cajal bodies (CBs) are the best-characterized organelles of mammalian cell nuclei. Like nucleoli, CBs concentrate ribonucleoproteins (RNPs), in particular, spliceosomal small nuclear RNPs (snRNPs) and small nucleolar RNPs (snoRNPs).
openaire   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

RNA Modification Related Diseases and Sensing Methods

Applied Sciences, 2023
Epitranscriptomics is the study of RNA base modifications, including functionally relevant transcriptomic changes. Epitranscriptomics has been actively studied in recent years and has been reported to play important roles in development, homeostasis, the
Mayuka Ohkawa, Masamitsu Konno
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Elucidating the Functions of Non-Coding RNAs from the Perspective of RNA Modifications

Non-Coding RNA, 2021
It is now commonly accepted that most of the mammalian genome is transcribed as RNA, yet less than 2% of such RNA encode for proteins. A majority of transcribed RNA exists as non-protein-coding RNAs (ncRNAs) with various functions. Because of the lack of
Venkata Naga Srikanth Garikipati, Shizuka Uchida   +1 more
doaj   +1 more source

The RNA modification database--1998 [PDF]

Nucleic Acids Research, 1998
The RNA modification database provides a comprehensive listing of posttranscriptionally modified nucleosides from RNA, and is maintained as an updated version of the initial printed report [Limbach,P.A., Crain,P.F. and McCloskey,J.A. (1994) Nucleic Acids Res. , 22, 2183-2196].
J A, McCloskey, P F, Crain
openaire   +2 more sources