Results 1 to 10 of about 184,382 (236)

A web-based atlas for exploring post-transcriptional regulation in the archaeon <i>Sulfolobus acidocaldarius</i>. [PDF]

mSystems
The archaeal domain contains organisms that are well-adapted to extreme conditions and changes in their habitat. Post-transcriptional regulation plays a key role in environmental adaptation, including rapid molecular responses to stress conditions.
Brück M, Daume M, Randau L, Gomes-Filho JV.   +3 more
europepmc   +2 more sources

The CoREST Complex Regulates Alternative Splicing by the Transcriptional Regulation of RNA Processing Genes in Melanoma Cells. [PDF]

Cells
RNA maturation, particularly splicing, depends on coordinated actions of RNA-binding proteins through post-transcriptional processing and constitutes a central mechanism of gene regulation. Aberrant splicing is associated with various diseases, including
Khan AA, Aptekmann AA, Min D, Povelaitis MC, Lee S, Ryu B.   +5 more
europepmc   +2 more sources

Microinflammation-Driven Gene Expression Dynamics in the Pathogenesis of Metabolic Disorders and Cancer. [PDF]

Biology (Basel)
Microinflammation serves as a central mechanism linking metabolic diseases and cancer. This study integrates gene expression profiles from irritable bowel syndrome (IBS), obesity, type 2 diabetes (T2D), colorectal cancer (CRC), renal cell carcinoma (RCC),
Cadungog MEGT, Tayo LL.
europepmc   +2 more sources

Editorial: RNA at a breaking point? Cytoplasmic cleavage and other post-transcriptional RNA processing in neurodevelopment and disease

Frontiers in Molecular Neuroscience, 2023
Monika Piwecka, Raphaelle Luisier, Raphaelle Luisier, Catia Andreassi   +3 more
doaj   +3 more sources

Regulatory role of RNA N6-methyladenosine modifications during skeletal muscle development

Frontiers in Cell and Developmental Biology, 2022
Functional cells in embryonic myogenesis and postnatal muscle development undergo multiple stages of proliferation and differentiation, which are strict procedural regulation processes.
Baojun Yu, Jiamin Liu, Juan Zhang, Tong Mu, Xiaofang Feng, Ruoshuang Ma, Yaling Gu   +6 more
doaj   +1 more source

Differential polyadenylation of ribosomal RNA during post-transcriptional processing inLeishmania [PDF]

Parasitology, 2005
The protozoan parasiteLeishmaniabelongs to the most ancient eukaryotic lineages and this is reflected in several distinctive biological features, such as eukaryotic polycistronic transcription and RNA trans-splicing. The disclosure of this organism's unusual characteristics leads to a better understanding of the origin and nature of fundamental ...
Decuypere, S., Vandesompele, J., Yardley, V., De Doncker, S., Laurent, T., Rijal, S., Llanos-Cuentas, A., Chappuis, F., Arevalo, J., Dujardin, J. C.   +9 more
openaire   +3 more sources

The Splice of Life: Does RNA Processing Have a Role in HIV-1 Persistence?

Viruses, 2021
Antiretroviral therapy (ART) suppresses HIV-1 replication but does not eradicate the virus. Persistence of HIV-1 latent reservoirs in ART-treated individuals is considered the main obstacle to achieving an HIV-1 cure.
Alexander O. Pasternak, Ben Berkhout
doaj   +1 more source

Post-transcriptional processing generates a diversity of 5′-modified long and short RNAs [PDF]

Nature, 2009
The transcriptomes of eukaryotic cells are incredibly complex. Individual non-coding RNAs dwarf the number of protein-coding genes, and include classes that are well understood as well as classes for which the nature, extent and functional roles are obscure. Deep sequencing of small RNAs (
Fejes-Tóth, Katalin, Sotirova, Vihra, Sachidanandam, Ravi, Assaf, Gordon, Hannon, Gregory J., Kapranov, Philipp, Foissac, Sylvain, Willingham, Aarron T., Duttagupta, Radha, Dumais, Erica, Gingeras, Thomas R., Affymetrix/Cold Spring Harbor Laboratory ENCODE Transcriptome Project   +11 more
openaire   +5 more sources

Single Molecule Imaging In Vivo Determines Post-Transcriptional RNA Processing Dynamics [PDF]

Biophysical Journal, 2014
The synthesis and splicing of pre-mRNA to form completed transcripts requires coordination between two large multi-subunit complexes (the RNA polymerase and the spliceosome). Using dual color single molecule RNA imaging in living human cells, we previously observed kinetic competition during the transcription cycle which resulted in both co- and post ...
Ferguson, Matthew L., Coulon, Antoine, de Turris, Valeria, Palangat, Murali, Chow, Carson C., Larson, Daniel R.   +5 more
openaire   +1 more source

RNA-binding proteins in tumor progression

Journal of Hematology & Oncology, 2020
RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and important biological functions. They are critical to maintain the transcriptome through post-transcriptionally controlling the processing and transportation of RNA ...
Hai Qin, Haiwei Ni, Yichen Liu, Yaqin Yuan, Tao Xi, Xiaoman Li, Lufeng Zheng   +6 more
doaj   +1 more source