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Differential polyadenylation of ribosomal RNA during post-transcriptional processing inLeishmania [PDF]
Parasitology, 2005 The protozoan parasiteLeishmaniabelongs to the most ancient eukaryotic lineages and this is reflected in several distinctive biological features, such as eukaryotic polycistronic transcription and RNA trans-splicing. The disclosure of this organism's unusual characteristics leads to a better understanding of the origin and nature of fundamental ...
Decuypere, S. +9 more
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Yeast Nrd1, Nab3, and Sen1 transcriptome-wide binding maps suggest multiple roles in post-transcriptional RNA processing [PDF]
RNA, 2011 RNA polymerase II transcribes both coding and noncoding genes, and termination of these different classes of transcripts is facilitated by different sets of termination factors. Pre-mRNAs are terminated through a process that is coupled to the cleavage/polyadenylation machinery, and noncoding RNAs in the yeast Saccharomyces cerevisiae are terminated ...
Paul Schaughency +5 more
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Post-transcriptional processing generates a diversity of 5′-modified long and short RNAs [PDF]
Nature, 2009 The transcriptomes of eukaryotic cells are incredibly complex. Individual non-coding RNAs dwarf the number of protein-coding genes, and include classes that are well understood as well as classes for which the nature, extent and functional roles are obscure. Deep sequencing of small RNAs (
Fejes-Tóth, Katalin +11 more
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Frontiers in Molecular Neuroscience, 2018 Neurons are morphologically complex cells that rely on the compartmentalization of protein expression to develop and maintain their extraordinary cytoarchitecture. This formidable task is achieved, at least in part, by targeting mRNA to subcellular compartments where they are rapidly translated.
Andreassi, C, Crerar, H, Riccio, A
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Single Molecule Imaging In Vivo Determines Post-Transcriptional RNA Processing Dynamics [PDF]
Biophysical Journal, 2014 The synthesis and splicing of pre-mRNA to form completed transcripts requires coordination between two large multi-subunit complexes (the RNA polymerase and the spliceosome). Using dual color single molecule RNA imaging in living human cells, we previously observed kinetic competition during the transcription cycle which resulted in both co- and post ...
Antoine Coulon +5 more
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Computational prediction of RNA structural motifs involved in posttranscriptional regulatory processes [PDF]
Proceedings of the National Academy of Sciences, 2008 Messenger RNA molecules are tightly regulated, mostly through interactions with proteins and other RNAs, but the mechanisms that confer the specificity of such interactions are poorly understood. It is clear, however, that this specificity is determined by both the nucleotide sequence and secondary structure of the mRNA.
Michal Rabani +2 more
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Transcription Is Just the Beginning of Gene Expression Regulation: The Functional Significance of RNA-Binding Proteins to Post-transcriptional Processes in Plants [PDF]
Plant and Cell Physiology, 2019 AbstractPlants have developed sophisticated mechanisms to compensate and respond to ever-changing environmental conditions. Research focus in this area has recently shifted towards understanding the post-transcriptional mechanisms that contribute to RNA transcript maturation, abundance and function as key regulatory steps in allowing plants to properly
Brian D Gregory +2 more
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The yeast nuclear gene suv3 affecting mitochondrial post-transcriptional processes encodes a putative ATP-dependent RNA helicase. [PDF]
Proceedings of the National Academy of Sciences, 1992 Mitochondrial gene expression is controlled largely through the action of products of the nuclear genome. The yeast nuclear gene suv3 has been implicated in a variety of mitochondrial posttranscriptional processes and in translation and, thus, represents a key control element in nuclear-mitochondrial interactions.
David Landsman +3 more
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Developmental Biology, 2021 Mesenchymal stem cells are candidates for therapeutic strategies in periodontal repair due to their osteogenic potential. In this study, we identified epigenetic markers during osteogenic differentiation, taking advantage of the individual pattern of mesenchymal cells of the periodontal ligament with high (h-PDLCs) and low (l-PDLCs) osteogenic capacity.
Rahyza I.F. Assis +10 more
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Production of Viral mRNA in Adenovirus-Transformed Cells by the Post-Transcriptional Processing of Heterogeneous Nuclear RNA Containing Viral and Cell Sequences [PDF]
Journal of Virology, 1973 Adenovirus 2-transformed cells contain virus-specific sequences which are covalently linked to cell-specific RNA sequences in heterogeneous nuclear RNA (HnRNA) molecules larger than 45 S . Virus sequences are identified by hybridization to viral DNA, and the cell sequences are detected by hybridization to cellular ...
R. Wall +3 more
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