Journal of Developmental Biology, 2018 An outstanding question in developmental neurobiology is how RNA processing events contribute to the regulation of neurogenesis. RNA processing events are increasingly recognized as playing fundamental roles in regulating multiple developmental events ...
Eugenia C. Olesnicky, Ethan G. Wright
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Probing the limits to microRNA-mediated control of gene expression [PDF]
, 2016 According to the `ceRNA hypothesis', microRNAs (miRNAs) may act as mediators of an effective positive interaction between long coding or non-coding RNA molecules, carrying significant potential implications for a variety of biological processes.
De Martino, Andrea +3 more
core +6 more sources
Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control [PDF]
, 2019 Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co-transcriptional RNA processing helps to ensure efficient and proper capping, splicing, and 3' end processing of different RNA species to help ensure ...
Hughes, Katlyn D. +3 more
core +1 more source
Synthetic RNA modules for fine-tuning gene expression levels in yeast by modulating RNase III activity [PDF]
, 2011 The design of synthetic gene networks requires an extensive genetic toolbox to control the activities and levels of protein components to achieve desired cellular functions.
Alper +62 more
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Yeast Nrd1, Nab3, and Sen1 transcriptome-wide binding maps suggest multiple roles in post-transcriptional RNA processing [PDF]
RNA, 2011 RNA polymerase II transcribes both coding and noncoding genes, and termination of these different classes of transcripts is facilitated by different sets of termination factors. Pre-mRNAs are terminated through a process that is coupled to the cleavage/polyadenylation machinery, and noncoding RNAs in the yeast Saccharomyces cerevisiae are terminated ...
Paul Schaughency +5 more
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RNA Metabolism Guided by RNA Modifications: The Role of SMUG1 in rRNA Quality Control
Biomolecules, 2021 RNA modifications are essential for proper RNA processing, quality control, and maturation steps. In the last decade, some eukaryotic DNA repair enzymes have been shown to have an ability to recognize and process modified RNA substrates and thereby ...
Lisa Lirussi +5 more
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A quantitative comparison of sRNA-based and protein-based gene regulation [PDF]
, 2008 Small, non-coding RNAs (sRNAs) play important roles as genetic regulators in prokaryotes. sRNAs act post-transcriptionally via complementary pairing with target mRNAs to regulate protein expression.
Berg HC +5 more
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Arabidopsis chloroplast quantitative editotype [PDF]
, 2013 Chloroplast C-to-U RNA editing is an essential post-transcriptional process. Here we analyzed RNA editing in Arabidopsis thaliana using strand-specific deep sequencing datasets from the wild-type and a mutant defective in RNA 3′ end maturation.
Castandet, Benoit +3 more
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DICER-LIKE2 plays a primary role in transitive silencing of transgenes in Arabidopsis. [PDF]
, 2008 Dicer-like (DCL) enzymes play a pivotal role in RNA silencing in plants, processing the long double-stranded RNA (dsRNA) that triggers silencing into the primary short interfering RNAs (siRNAs) that mediate it.
Bowman, Lewis H +8 more
core +11 more sources
Transcription Is Just the Beginning of Gene Expression Regulation: The Functional Significance of RNA-Binding Proteins to Post-transcriptional Processes in Plants [PDF]
Plant and Cell Physiology, 2019 AbstractPlants have developed sophisticated mechanisms to compensate and respond to ever-changing environmental conditions. Research focus in this area has recently shifted towards understanding the post-transcriptional mechanisms that contribute to RNA transcript maturation, abundance and function as key regulatory steps in allowing plants to properly
Brian D Gregory +2 more
openaire +3 more sources