RNA-based regulation: dynamics and response to perturbations of competing RNAs [PDF]
, 2013 The observation that, through a titration mechanism, microRNAs (miRNAs) can act as mediators of effective interactions among their common targets (competing endogenous RNAs or ceRNAs) has brought forward the idea ('ceRNA hypothesis') that RNAs can ...
De Martino, Andrea +2 more
core +3 more sources
Control of RNA degradation in cell fate decision
Frontiers in Cell and Developmental Biology, 2023 Cell fate is shaped by a unique gene expression program, which reflects the concerted action of multilayered precise regulation. Substantial research attention has been paid to the contribution of RNA biogenesis to cell fate decisions.
Mingqiang Deng +5 more
doaj +1 more source
The 5'-3' exoribonuclease Pacman (Xrn1) regulates expression of the heat shock protein Hsp67Bc and the microRNA miR-277-3p in Drosophila wing imaginal discs [PDF]
, 2013 Pacman/Xrn1 is a highly conserved exoribonuclease known to play a critical role in gene regulatory events such as control of mRNA stability, RNA interference and regulation via miRNAs.
Bate M +7 more
core +1 more source
An alanine expanded PABPN1 causes increased utilization of intronic polyadenylation sites
npj Aging and Mechanisms of Disease, 2017 Muscle degeneration: RNA structures as modulator of muscle function Transcriptional and post-transcriptional regulation of gene expression has a fundamental role in shaping the protein landscape.
Tooba Abbassi-Daloii +6 more
doaj +1 more source
Identification of human mitochondrial RNA cleavage sites and candidate RNA processing factors
BMC Biology, 2022 Background The human mitochondrial genome is transcribed as long strands of RNA containing multiple genes, which require post-transcriptional cleavage and processing to release functional gene products that play vital roles in cellular energy production.
Guillermo Carbajosa +2 more
doaj +1 more source
MicroRNA in control of gene expression: An overview of nuclear functions [PDF]
, 2016 The finding that small non-coding RNAs (ncRNAs) are able to control gene expression in a sequence specific manner has had a massive impact on biology. Recent improvements in high throughput sequencing and computational prediction methods have allowed the
Catalanotto, Caterina +2 more
core +2 more sources
The yeast nuclear gene suv3 affecting mitochondrial post-transcriptional processes encodes a putative ATP-dependent RNA helicase. [PDF]
Proceedings of the National Academy of Sciences, 1992 Mitochondrial gene expression is controlled largely through the action of products of the nuclear genome. The yeast nuclear gene suv3 has been implicated in a variety of mitochondrial posttranscriptional processes and in translation and, thus, represents a key control element in nuclear-mitochondrial interactions.
David Landsman +3 more
openaire +3 more sources
Frontiers in Immunology, 2023 IntroductionBromodomain-containing Protein 4 (BRD4) is a transcriptional regulator which coordinates gene expression programs controlling cancer biology, inflammation, and fibrosis.
Morgan W. Mann +11 more
doaj +1 more source
Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer's disease. [PDF]
, 2017 The abundance of mRNA is mainly determined by the rates of RNA transcription and decay. Here, we present a method for unbiased estimation of differential mRNA decay rate from RNA-sequencing data by modeling the kinetics of mRNA metabolism.
Alkallas, Rached +3 more
core +3 more sources
Developmental Biology, 2021 Mesenchymal stem cells are candidates for therapeutic strategies in periodontal repair due to their osteogenic potential. In this study, we identified epigenetic markers during osteogenic differentiation, taking advantage of the individual pattern of mesenchymal cells of the periodontal ligament with high (h-PDLCs) and low (l-PDLCs) osteogenic capacity.
Rahyza I.F. Assis +10 more
openaire +4 more sources