Results 31 to 40 of about 184,382 (236)

Bromodomain-containing Protein 4 regulates innate inflammation via modulation of alternative splicing

Frontiers in Immunology, 2023
IntroductionBromodomain-containing Protein 4 (BRD4) is a transcriptional regulator which coordinates gene expression programs controlling cancer biology, inflammation, and fibrosis.
Morgan W. Mann, Yao Fu, Robert L. Gearhart, Xiaofang Xu, David S. Roberts, Yi Li, Jia Zhou, Ying Ge, Ying Ge, Ying Ge, Allan R. Brasier, Allan R. Brasier   +11 more
doaj   +1 more source

Transcription Is Just the Beginning of Gene Expression Regulation: The Functional Significance of RNA-Binding Proteins to Post-transcriptional Processes in Plants [PDF]

Plant and Cell Physiology, 2019
AbstractPlants have developed sophisticated mechanisms to compensate and respond to ever-changing environmental conditions. Research focus in this area has recently shifted towards understanding the post-transcriptional mechanisms that contribute to RNA transcript maturation, abundance and function as key regulatory steps in allowing plants to properly
Brian D Gregory, Bishwas Sharma, Wil Prall   +2 more
openaire   +2 more sources

Molecular Network Analysis Suggests a Logical Hypothesis for the Pathological Role of C9orf72 in Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Journal of Central Nervous System Disease, 2014
Background Expanded GGGGCC hexanucleotide repeats, ranging from hundreds to thousands in number, located in the noncoding region of the chromosome 9 open reading frame 72 ( C9orf72 ) gene represent the most common genetic abnormality for familial and ...
Jun-Ichi Satoh, Yoji Yamamoto, Shouta Kitano, Mika Takitani, Naohiro Asahina, Yoshihiro Kino   +5 more
doaj   +1 more source

Post-transcriptional Processing of mRNA in Neurons: The Vestiges of the RNA World Drive Transcriptome Diversity

Frontiers in Molecular Neuroscience, 2018
Neurons are morphologically complex cells that rely on the compartmentalization of protein expression to develop and maintain their extraordinary cytoarchitecture. This formidable task is achieved, at least in part, by targeting mRNA to subcellular compartments where they are rapidly translated.
Andreassi, C, Crerar, H, Riccio, A
openaire   +4 more sources

A genome-wide tethering screen reveals novel potential post-transcriptional regulators in Trypanosoma brucei. [PDF]

PLoS Pathogens, 2014
In trypanosomatids, gene expression is regulated mainly by post-transcriptional mechanisms, which affect mRNA processing, translation and degradation. Currently, our understanding of factors that regulate either mRNA stability or translation is rather ...
Esteban D Erben, Abeer Fadda, Smiths Lueong, Jörg D Hoheisel, Christine Clayton   +4 more
doaj   +1 more source

Inhibition of Post-Transcriptional RNA Processing by CDK Inhibitors and Its Implication in Anti-Viral Therapy

PLoS ONE, 2014
Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and RNA polymerase II mediated transcription. Several pharmacological CDK inhibitors are currently in clinical trials as potential cancer therapeutics and some of them also exhibit antiviral effects.
Holčáková, J., Müller, P., Tomasec, P., Hrstka, R., Nekulová, M., Kryštof, V. (Vladimír), Strnad, M. (Miroslav), Wilkinson, G. W. G., Vojtěšek, B.   +8 more
openaire   +5 more sources

Transcriptional and post-transcriptional processes regulate expression of RNA encoding the small subunit of ribulose-1, 5-biphosphate carboxylase differently in petunia and in soybean [PDF]

Nucleic Acids Research, 1990
The effects of white light, far-red light and darkness on the in vitro transcription and RNA levels of the small subunit of ribulose-1,5-bisphosphate carboxylase (rbcS) were investigated in petunia and in soybean. In petunia plants treated with 48 hours of darkness the in vitro transcription rate of two of the rbcS subfamilies of petunia, rbcS A and ...
D M, Thompson, R B, Meagher
openaire   +2 more sources

Nanodynamo quantifies subcellular RNA dynamics revealing extensive coupling between steps of the RNA life cycle

Nature Communications
The coordinated action of transcriptional and post-transcriptional machineries shapes gene expression programs at steady state and determines their concerted response to perturbations.
Lucia Coscujuela Tarrero, Valeria Famà, Giacomo D’Andrea, Simone Maestri, Anna de Polo, Stefano Biffo, Mattia Furlan, Mattia Pelizzola   +7 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Mycobacterial RNA isolation optimized for non-coding RNA: high fidelity isolation of 5S rRNA from Mycobacterium bovis BCG reveals novel post-transcriptional processing and a complete spectrum of modified ribonucleosides [PDF]

Nucleic Acids Research, 2014
A major challenge in the study of mycobacterial RNA biology is the lack of a comprehensive RNA isolation method that overcomes the unusual cell wall to faithfully yield the full spectrum of non-coding RNA (ncRNA) species. Here, we describe a simple and robust procedure optimized for the isolation of total ncRNA, including 5S, 16S and 23S ribosomal RNA (
Hia, Fabian, Chionh, Yok Hian, Pang, Yan Ling Joy, DeMott, Michael S., McBee, Megan E., Dedon, Peter C.   +5 more
openaire   +4 more sources