Results 151 to 160 of about 29,788 (255)

FGF21‐Mediated Upregulation of SIRT1 Delays Intervertebral Disc Degeneration by Promoting PINK1/Parkin Dependent Mitophagy Through Deacetylation of FOXO3

Aging Cell, Volume 25, Issue 4, April 2026.
FGF21 upregulates SIRT1 to promote the deacetylation of FOXO3 at sites K241, K258, K289, and K568, thereby activating PINK1/Parkin‐dependent mitophagy, suppressing nucleus pulposus cell senescence, and delaying intervertebral disc degeneration. ABSTRACT Intervertebral Disc Degeneration (IDD) is a common degenerative spinal disease and a leading cause ...
Zuo‐long Wu, Rui Ran, Qi‐qi Xie, Cong Zhang, Ya‐jun Chen, Peng Cheng, Ke‐Ping Wang, Hai‐hong Zhang   +7 more
wiley   +1 more source

Targeting inflammation in cardiometabolic disease: Icosapent ethyl modulates monocyte‐derived macrophages isolated from patients with cardiovascular disease with or without type 2 diabetes

Diabetic Medicine, Volume 43, Issue 4, April 2026.
Abstract Aims Despite intensive lipid‐lowering therapy, individuals with atherosclerotic cardiovascular disease (ASCVD) exhibit residual inflammatory risk, which drives recurrent cardiovascular events. This risk is amplified in type 2 diabetes mellitus (T2DM), where a pro‐inflammatory milieu accelerates atherogenesis. Monocyte‐derived macrophages (MDMs)
J. K. Ward, M. U. Shah, K. Lee, P. E. Squires, C. E. Hills   +4 more
wiley   +1 more source

Different Acupuncture Therapies Combined with Sulfasalazine for the Treatment of Ankylosing Spondylitis: Bayesian Network Meta-Analysis

Journal of Pain Research
Kaili Han,1,2 Mengquan Yu,3 Jing Chen,4 Shiheng Wang1 1School of Traditional Chinese Medicine, Binzhou Medical University, Yantai, People’s Republic of China; 2The Fifth Hospital of Qinhuangdao City, Qinhuangdao, People’s Republic of China; 3Muping ...
Han K, Yu M, Chen J, Wang S
doaj  

Does Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Skeletal muscle in individuals with cerebral palsy (CP) may undergo accelerated aging through mechanisms shared with age‐related sarcopenia. Representative overlapping molecular and cellular features include, for example, neuromuscular alterations, impaired satellite cell function and niche composition, chronic inflammation, metabolic deficits, reduced
Oscar Horwath, Sebastian Edman, Sudarshan Dayanidhi, Davis Englund, Mark D. Peterson, Ferdinand von Walden   +5 more
wiley   +1 more source

Auxiliary propulsion requirements for large space systems [PDF]

An insight into auxiliary propulsion systems (APS) requirements for large space systems (LSS) launchable by a single shuttle is presented. In an effort to scope the APS requirements for LSS, a set of generic LSSs were defined.
Machles, G. W., Maloy, J. E., Smith, W. W.   +2 more
core   +1 more source

Senescent-Like Myofibers Contribute to Anti-Regenerative Cytokine Signaling in Duchenne Muscular Dystrophy. [PDF]

FASEB J
p16 expression in DMD model rats induces a senescent‐like state in myofibers accompanied by p16 and cytokine gene expression, reshaping systemic humoral environments. This cytokine‐rich milieu suppresses skeletal muscle regeneration, as demonstrated by impaired regeneration of transplanted wild‐type muscle.
Ikeda M, Tanaka Y, Sugihara H, Matsuwaki T, Yamanouchi K.   +4 more
europepmc   +2 more sources

Inhibition of miMOMP-induced SASP to combat age-related disease

Frontiers in Aging
Cellular senescence, first described in 1961, was initially observed in normal human fibroblasts that ceased proliferating after a finite number of divisions in culture. This process is triggered by various stimuli, including oxidative stress, chromatin modifications and oncogene activation, characterized by irreversible cell-cycle arrest, resistance ...
Xiaoli Liao, Zhennan Guo, Zhennan Guo, Mouhai He, Yichun Zhang   +4 more
openaire   +3 more sources

Cancer‐associated fibroblasts are associated with CD8+ T cell depletion and poor prognosis in colorectal adenocarcinoma: a multi‐omics and machine learning analysis

The Journal of Pathology: Clinical Research, Volume 12, Issue 2, March 2026.
Abstract Fibroblastic proliferation in various tumor microenvironments influences cancer survival through complex interactions with diverse immune responses. This study investigated the impact of histologically unique activated cancer‐associated fibroblasts (aCAFs) on survival outcomes and immune responses and examined their association with various ...
Myungsun Shim, One‐Zoong Kim, Byoung Kwan Son, Jung Ki Jo, Seung Wook Lee, Hong Sang Moon, Hyung Suk Kim, Mi Jung Kwon, Sung Hak Lee, Yung‐Kyun Noh, Kyueng‐Whan Min   +10 more
wiley   +1 more source

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, Volume 13, Issue 16, 18 March 2026.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

The Abstracts of SASP 2001

Australian Journal of Psychology, 2001
Michael Platow, Yoshihisa Kashima
openaire   +1 more source