Results 181 to 190 of about 29,788 (255)

The Yin-Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease. [PDF]

Biocell
Ruden DM.
europepmc   +1 more source

p38 MAPK inhibits nonsense-mediated RNA decay in response to persistent DNA damage in noncycling cells [PDF]

, 2017
Cheruiyot, Abigael, Flanagan, Kevin C., Nickless, Andrew, Piwnica-Worms, David, Stewart, Sheila A., You, Zhongsheng   +5 more
core   +2 more sources

Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proliferation, while the senescence‐associated secretory phenotype (SASP) secretion enhances antitumor immunity by activating cytotoxic T cells.
Huajie Mao, Wanning Liu, Yuanyuan Su, Yuxuan Ma, Xiaodi Zhao, Yuanyuan Lu   +5 more
wiley   +1 more source

Signifiance of autoimmune reactions to pancreatic juice in Crohn´s disease [PDF]

, 1988
Goebell, Harald, Malchow, H., Otte, M., Peskar, B. M., Scriba, Peter Christian, Stöcker, W.   +5 more
core   +1 more source

Senescent Mesenchymal Stromal Cells Differentially Alter Adipogenesis in Adipose Tissue, Skeletal Muscle, and Bone Marrow

Obesity, Volume 34, Issue 3, Page 652-661, March 2026.
ABSTRACT Objective Aging alters mesenchymal stromal cell (MSC) function, leading to dysregulated adipogenesis across tissues through biased lineage commitment. Fat redistribution from adipose depots to skeletal muscle and bone marrow is common in aging, but the underlying mechanisms remain unclear.
Xu Zhang, Madison L. Doolittle, Ting Fan, Utkarsh Tripathi, Yan Er Ng, Xinyi Jiang, João F. Passos, Diana Jurk, David G. Monroe, Tamara Tchkonia, James L. Kirkland, Paul D. Robbins, Sundeep Khosla, Nathan K. LeBrasseur   +13 more
wiley   +1 more source

Chondrocyte Senescence in Osteoarthritis: Potential Targets and Pharmacological Interventions. [PDF]

Cartilage
Tan D, Guo J, Wang T, Yang S, Liu J, Wang D, Li W.   +6 more
europepmc   +1 more source

Ageing Through the Looking‐Glass: The Different Flavours of Clonal Haematopoiesis

Aging Cell, Volume 25, Issue 3, March 2026.
Different forms of CH share common germline and environmental risk factors and have overlapping prevalence and disease associations, suggesting common underlying ageing processes. We explore intersections of different forms of CH, clinical implications of these, and how this enhances our understanding of the biology of ageing.
Jasmine Singh, David J. Curtis, Le Thi Phuong Thao, Erica M. Wood, Zoe K. McQuilten   +4 more
wiley   +1 more source

DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment

Aging Cell, Volume 25, Issue 3, March 2026.
We found very little overlap between CpGs that were correlated with in vitro senescence, chronological age, and mortality. While we were able to train epigenetic clocks with CpGs that accelerated with cellular senescence, these clocks did not decelerate with Senolytic treatment. ABSTRACT Epigenetic clocks are commonly used aging biomarkers based on DNA
Jessica Kasamoto, John González, Yaroslav Markov, Raghav Sehgal, Edwin Lee, Varun B. Dwaraka, Ryan Smith, Albert T. Higgins‐Chen   +7 more
wiley   +1 more source

Correction: Circulating senescence-associated secretory phenotype factors across the stages of type 1 diabetes in a cross-sectional cohort. [PDF]

Sci Rep
Préfontaine C, Pipella J, Heidinger I, Alcasid N, Thompson PJ.   +4 more
europepmc   +1 more source

Aging Triggers an Intestinal Energy Crisis and HDL3 Deficiency Disrupting Gut–Liver Axis Homeostasis

Aging Cell, Volume 25, Issue 3, March 2026.
The age‐related mitochondrial energy crisis and the consequent disruption of intestinal HDL3 biosynthesis converge to disrupt the gut–liver HDL3‐LPS/TLR4 axis, compromising hepatic anti‐inflammatory function and driving liver injury, an effect reversible upon NMN administration.
Yumeng Li, Tongtong Bao, Lumin Gao, Xutong Tian, Junyu Xue, Caike Jin, Shujin Wang, Xin Wu   +7 more
wiley   +1 more source