Results 191 to 200 of about 29,788 (255)

Research progress on the spatiotemporal dynamics of therapy-induced senescence in remodeling the tumor microenvironment. [PDF]

Front Immunol
Zhao Q, Yu Y, Pu C, Zheng S, Chen L, Zeng F, Liu L, Li D.   +7 more
europepmc   +1 more source

Decoding Senescence‐Driven Heterogeneity in Early‐Onset Colorectal Cancer for Prognostic and Therapeutic Stratification

Cancer Science, Volume 117, Issue 3, Page 818-835, March 2026.
We uncovered pronounced and heterogeneous tumor senescence in EOCRC, independent of age. By integrating multi‐omics and single‐cell analyses, we developed EO‐Senscore, a prognostic tool that stratifies patients by immune phenotype and therapy response, enabling precision treatment using immunotherapy or senolytic agents. ABSTRACT Early‐onset colorectal
Du Cai, Mingru Mai, Rende Huang, Haoning Qi, Xingzhi Feng, Qianling Gao, Yinmeng Zhang, Chenghang Li, Xiaojian Wu, Yize Mao, Zihuan Yang, Feng Gao   +11 more
wiley   +1 more source

Mitochondrial bioenergetics-SASP crosstalk determines senolytic efficacy in therapy-induced senescence. [PDF]

Cell Death Discov
Llop-Hernández À, Verdura S, López J, Martin-Castillo B, Menendez JA, Cuyàs E.   +5 more
europepmc   +1 more source

A Senolytic Strategy for Metabolic Health: Why the Endothelium Matters

iNew Medicine, Volume 2, Issue 1, March 2026.
He Liang, Yu Wang, Yang Zhang, Xiaoqiang Tang   +3 more
wiley   +1 more source

Effects of Aerosol Extract From Heated Tobacco Products on Senescence‐Associated Gene Expression in Human Lung Fibroblasts

Geriatrics &Gerontology International, Volume 26, Issue 3, March 2026.
Repeated exposure to aerosols from heated tobacco products may affect senescence‐associated factors. ABSTRACT Aim Cellular senescence is associated with an increased risk of various diseases. Although heated tobacco products (HTPs) have become widespread substitutes for conventional combustible cigarettes, their role in cellular senescence remains ...
Ayami Sato, Satsuki Kasahara, Akihito Ishigami   +2 more
wiley   +1 more source

Senescent endothelial cells: key commanders of the cellular communication network within atherosclerotic plaques. [PDF]

Front Immunol
Xie F, Xi C, Bao G, Yang B, Zheng X, Fu B, Zheng Z.   +6 more
europepmc   +1 more source

Senomorphic Activity of a Novel Standardized Propolis Extract in Human Dermal Fibroblasts: Molecular Insights Into Clinically Proven Anti‐Wrinkle Efficacy

Journal of Cosmetic Dermatology, Volume 25, Issue 3, March 2026.
ABSTRACT Background We recently demonstrated in a randomized controlled trial (RCT) that a Standardized Propolis Extract (SPE), produced via a patented non‐alcoholic PEG 400/lecithin process, achieves significant clinical anti‐wrinkle efficacy (34% wrinkle depth reduction).
Božo Radić, Jelena Šuran
wiley   +1 more source

The dysregulation of innate immunity by Porphyromonas gingivalis in the etiology of Alzheimer's disease

Journal of Internal Medicine, Volume 299, Issue 3, Page 328-348, March 2026.
Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron, Jennifer S. Lin, Mark I. Ryder, Peter Bergman   +3 more
wiley   +1 more source

p16-mediated G0/G1 cell cycle arrest leads to SASP and fibrosis in Fuchs endothelial corneal dystrophy. [PDF]

Cell Death Dis
Parekh M, Adhikari Y, Deshpande N, Wong R, Price MO, Price FW, Jurkunas UV.   +6 more
europepmc   +1 more source

The Interplay Between Cellular Senescence and Lipid Metabolism in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). [PDF]

Int J Mol Sci
Mastoridou EM, Goussia AC, Kataki A, Koniaris E, Glantzounis GK, Papoudou-Bai A, Kanavaros P, Charchanti AV.   +7 more
europepmc   +1 more source