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Signatures analysis systems prototype (SASP)
2009 IEEE Conference on Technologies for Homeland Security, 2009Sim-G Technologies, LLC (Sim-G), has developed a prototype collaborative system to aid in countering the threat of improvised explosive devices (IED). This is accomplished through the use of knowledge discovery, collaboration, data mining, signature visualization and GIS tools.
Dennis G. Perry +2 more
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Abstract 5683: Growth hormone as a SASP component
Cancer Research, 2022Abstract Senescence, largely initiated by unrepaired DNA damage, is initially sustained by upregulated p53. Although senescent cells enter proliferative arrest, early p53 supression may result in senescent cells re-entering the cell cycle.
Vera Chesnokova +3 more
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Astrocyte senescence and SASP in neurodegeneration: tau joins the loop
Cell Cycle, 2021Tau accumulation is a core component of Alzheimer's disease and other neurodegenerative tauopathies. While tau's impact on neurons is a major area of research, the effect of extracellular tau on astrocytes is largely unknown. This article summarizes our recent studies showing that astrocyte senescence plays a critical role in neurodegenerative diseases
Kyra Ungerleider +6 more
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SASP gene delivery: A novel antibacterial approach
Drug News & Perspectives, 2009Antibiotic resistance is a global problem, and with bacteria having developed resistance to all approved antibacterial agents there is a growing need for innovative solutions. Phico Therapeutics has developed a new class of antibacterial agent, a platform technology called SASPject.
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Unmasking senescence: context-dependent effects of SASP in cancer
Nature Reviews Cancer, 2019Cellular senescence plays a critical role in tumorigenesis. Once thought of as a tissue culture artefact by some researchers, senescence is now a major field of study. Although there are common molecular mechanisms that enforce the growth arrest that characterizes the phenotype, the impact of senescence is varied and can, in some instances, have ...
Douglas V. Faget +2 more
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Effects of NAT2 polymorphism on SASP pharmacokinetics in Chinese population
Clinica Chimica Acta, 2009Sulfasalazine (SASP) pharmacologic actions are widely applied in clinical therapy. The role of N-Acetyltransferase 2 (NAT2) in the pharmacokinetics of SASP and its metabolites has not been clarified. We investigated the effects of genetic polymorphism of NAT2 on pharmacokinetic profiles of SASP and its two metabolites, sulfapyridine (SP) and N ...
Jing-Jing, Ma +5 more
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Detection of the Senescence-Associated Secretory Phenotype (SASP)
2012Cellular senescence suppresses cancer by eliminating potentially oncogenic cells, participates in tissue repair, contributes to cancer therapy, and promotes organismal aging. Numerous activities of senescent cells depend on the aptitude of these cells to secrete myriads of bioactive molecules, a behavior termed the senescence-associated secretory ...
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The Triumf Second Arm Spectrometer System (SASP)
2009The Second Arm SPectrometer (SASP) is a 130 ton 769 M e V / c QQClamshell magnetic spectrometer which pivots at the T2 location on the beam line 4B, and operates simultaneously in a coincidence mode with the existing M R S spectrometer. The new spectrometer was installed during the 1993-1994 and has undergone a series of commissioning runs as a single ...
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