Results 31 to 40 of about 357,927 (309)

A Poglut1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss [PDF]

, 2016
Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism activated upon muscle damage and regulated by Notch signaling. In a family with autosomal recessive limbgirdle muscular dystrophy, we identified a missense mutation in ...
Cabrera Serrano, Macarena, Fernández-Chacón, Rafael, Gómez-Sánchez, Leonardo, Nieto González, José Luis, Rivero, María C, Servián Morilla, Emilia   +5 more
core   +1 more source

Forever young: rejuvenating muscle satellite cells [PDF]

Frontiers in Aging Neuroscience, 2015
A hallmark of aging is alteration of organismal homeostasis and progressive decline of tissue functions. Alterations of both cell intrinsic functions and regenerative environmental cues contribute to the compromised stem cell activity and reduced regenerative capability occurring in aged muscles.
Lucia eLatella, Lucia eLatella, Luca eMadaro, Luca eMadaro   +3 more
openaire   +3 more sources

Lysine Distinctively Manipulates Myogenic Regulatory Factors and Wnt/Ca²⁺ Pathway in Slow and Fast Muscles, and Their Satellite Cells of Postnatal Piglets

Cells
Muscle regeneration, representing an essential homeostatic process, relies mainly on the myogenic progress of resident satellite cells, and it is modulated by multiple physical and nutritional factors.
Xiaofan Wang, Xiaoyin Zong, Mao Ye, Chenglong Jin, Tao Xu, Jinzeng Yang, Chunqi Gao, Xiuqi Wang, Huichao Yan   +8 more
doaj   +1 more source

Niche Cadherins Control the Quiescence-to-Activation Transition in Muscle Stem Cells

Cell Reports, 2017
Many adult stem cells display prolonged quiescence, promoted by cues from their niche. Upon tissue damage, a coordinated transition to the activated state is required because non-physiological breaks in quiescence often lead to stem cell depletion and ...
Aviva J. Goel, Marysia-Kolbe Rieder, Hans-Henning Arnold, Glenn L. Radice, Robert S. Krauss   +4 more
doaj   +1 more source

Functionally heterogeneous human satellite cells identified by single cell RNA sequencing. [PDF]

, 2020
Although heterogeneity is recognized within the murine satellite cell pool, a comprehensive understanding of distinct subpopulations and their functional relevance in human satellite cells is lacking.
Aguilar, Aizarani, Alexander, Alonso-Martin, Arpino, Arpke, Baker, Biernacka, Bigot, Boscher, Brooks, Butler, Chakkalakal, Chakkalakal, Charville, Cheung, Cho, Collins, Dell'Orso, Deng, Der Vartanian, Dumont, Elgort, Fan, Flint, Fukada, Garcia, Garcia, Gayraud-Morel, Gnocchi, Guruharsha, Gvaramia, Hai, Hurley, Inoue, Jiang, Kann, Karantza, Kuang, Kumar, Lee, Liu, Liu, Liu, Machado, Macosko, Mallaney, Marchand, Marti, Martinez, Mauro, Min, Moniot, Montarras, Mourkioti, Ng, Nicol, Ono, Pal, Pala, Pallafacchina, Pan, Pomerantz, Porpiglia, Qing, Qiu, Qiu, R Development Core Team, Rozkalne, Rubenstein, Ryall, Sacco, Satija, Scaramozza, Schiaffino, Schmidt, Schroder, Shea, Sheikh, Shen, Sherwood, Si, Siegel, Simeckova, Smith, Song, Sousa-Victor, Stark, Takahashi, Tierney, Trapnell, Tzioras, Uezumi, van Velthoven, Volonte, Wagner, Weinstein, Wu, Wu, Xu, Yang, Yeh, Yi, Yu, Yu, Zhang, Zheng   +106 more
core   +1 more source

Single Cell Analysis Identifies the miRNA Expression Profile of a Subpopulation of Muscle Precursor Cells Unique to Humans With Type 2 Diabetes

Frontiers in Physiology, 2018
MicroRNAs (miRNAs) take part in regulating central cellular processes such as differentiation and metabolism. We have previously shown that muscle progenitor cells derived from individuals with type 2 diabetes (T2DM) have a dysregulated miRNA profile. We
Tora I. Henriksen, Tora I. Henriksen, Sarah E. Heywood, Ninna S. Hansen, Bente K. Pedersen, Camilla C. Scheele, Camilla C. Scheele, Søren Nielsen   +7 more
doaj   +1 more source

Hypoxia promotes proliferation and inhibits myogenesis in broiler satellite cells

Poultry Science
: Breast muscle myopathies in broilers compromise meat quality and continue to plague the poultry industry. Broiler breast muscle myopathies are characterized by impaired satellite cell (SC)-mediated repair, and localized tissue hypoxia and dysregulation
Usuk Jung, Minjeong Kim, Presley Dowker-Key, Simon Noë, Ahmed Bettaieb, Elizabeth Shepherd, Brynn Voy   +6 more
doaj   +1 more source

New insights into the epigenetic control of satellite cells [PDF]

, 2015
Epigenetics finely tunes gene expression at a functional level without modifying the DNA sequence, thereby contributing to the complexity of genomic regulation.
Adamo, Sergio, Marroncelli, Nicoletta, Moresi, Viviana   +2 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source