Results 31 to 40 of about 99,362 (212)

Three-dimensional niche stiffness synergizes with Wnt7a to modulate the extent of satellite cell symmetric self-renewal divisions [PDF]

, 2020
Satellite cells (SCs), the resident adult stem cells of skeletal muscle, are required for tissue repair throughout life. While many signaling pathways are known to control SC self-renewal, less is known about the mechanisms underlying the spatiotemporal ...
Nissar, Aliyah A, Liu, Haijiao, Sun, Yu, Ferreira, Silvia A, Gilbert, Penney M, Simmons, Craig A, Cheng, Richard Y, Gentleman, Eileen, Moyle, Louise A, Davoudi, Sadegh   +9 more
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CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration [PDF]

, 2021
Regeneration of skeletal muscle requires resident stem cells called satellite cells. Here, we report that the chromatin remodeler CHD4, a member of the nucleosome remodeling and deacetylase (NuRD) repressive complex, is essential for the expansion and ...
Sreenivasan, Krishnamoorthy, Segalés, Jessica, Gomez-del Arco, Pablo, Kim, Johnny, Relaix, F., Redondo, Juan Miguel, Rodríguez de la Rosa, Alejandra, Rodríguez-delaRosa, Alejandra, Muñoz Cánoves, Pura, 1962-, Arco, Pablo Gómez-Del, Relaix, Frederic, Johnny, Kim, Braun, Thomas, Munoz-Canoves, P., Gómez del Arco, Pablo, Mesquita, D., Segalés Dalmau, Jessica, Serrano Sánchez, Antonio L., Serrano, Antonio L, Rodriguez-delaRosa, A., Ianni, A., Serrano, Antonio, Gomez-del Arco, P., Braun, T., Ianni, Alessandro, Muñoz-Cánoves, Pura, Perdiguero, Eusebio, Serrano, A., Kim, J., Espejo, Isabel, Espejo, I., Sreenivasan, K., Miguel Redondo, J., Perdiguero, Eusebio, 1968-, Di Croce, Luciano, Segales, J., Di Croce, L., Perdiguero, E., Mesquita, Diana   +38 more
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Skeletal Muscle Adaptations to Exercise Training in Young and Aged Horses

Frontiers in Aging, 2021
In aged humans, low-intensity exercise increases mitochondrial density, function and oxidative capacity, decreases the prevalence of hybrid fibers, and increases lean muscle mass, but these adaptations have not been studied in aged horses. Effects of age
Christine M. Latham, Randi N. Owen, Emily C. Dickson, Chloey P. Guy, Sarah H. White-Springer   +4 more
doaj   +1 more source

Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes [PDF]

, 2010
Copyright: © 2010 Stimpson et al.Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly
Sullivan, Beth A., Sullivan, Beth A, Karen E. Hayden, Kaitlin M. Stimpson, Beth A Sullivan, Bridger Joanna M., Song, IY, Sullivan, BA, Ihn Young Song, Beth A. Sullivan, Karen E Hayden, Hayden, Karen E., Jauch, A, Bridger, Joanna M., Joanna M Bridger, Joanna M. Bridger, Hayden, Karen E, Song Ihn Young, Jauch, Anna, Holtgreve-Grez, Heidi, Heidi Holtgreve-Grez, Holtgreve-Grez Heidi, Stimpson, Kaitlin M, Stimpson, KM, Kaitlin M Stimpson, Anna Jauch, Bridger, JM, Jauch Anna, Bridger, Joanna M, Stimpson Kaitlin M., Sullivan Beth A., Song, Ihn Young, Hayden Karen E., Hayden, KE, Holtgreve-Grez, H, Stimpson, Kaitlin M.   +35 more
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Lysine Distinctively Manipulates Myogenic Regulatory Factors and Wnt/Ca²⁺ Pathway in Slow and Fast Muscles, and Their Satellite Cells of Postnatal Piglets

Cells
Muscle regeneration, representing an essential homeostatic process, relies mainly on the myogenic progress of resident satellite cells, and it is modulated by multiple physical and nutritional factors.
Xiaofan Wang, Xiaoyin Zong, Mao Ye, Chenglong Jin, Tao Xu, Jinzeng Yang, Chunqi Gao, Xiuqi Wang, Huichao Yan   +8 more
doaj   +1 more source

Niche Cadherins Control the Quiescence-to-Activation Transition in Muscle Stem Cells

Cell Reports, 2017
Many adult stem cells display prolonged quiescence, promoted by cues from their niche. Upon tissue damage, a coordinated transition to the activated state is required because non-physiological breaks in quiescence often lead to stem cell depletion and ...
Aviva J. Goel, Marysia-Kolbe Rieder, Hans-Henning Arnold, Glenn L. Radice, Robert S. Krauss   +4 more
doaj   +1 more source

Integrated Functions of Pax3 and Pax7 in the Regulation of Proliferation, Cell Size and Myogenic Differentiation

, 2009
Pax3 and Pax7 are paired-box transcription factors with roles in developmental and adult regenerative myogenesis. Pax3 and Pax7 are expressed by postnatal satellite cells or their progeny but are down regulated during myogenic differentiation.
Morgan, JE, Zammit, PS, Boldrin, L, Collins, C A, Robert B White, Peter S Zammit, White, R B, Relaix, F, Gnocchi, VF, Jennifer E Morgan, Ana Perez-Ruiz, Viola F Gnocchi, Frederic Relaix, Gnocchi, V F, Zammit, P S, Collins, CA, Charlotte A Collins, White, RB, Perez-Ruiz, A, Robert B. White, Jennifer E. Morgan, Viola F. Gnocchi, Morgan, J E, Luisa Boldrin, Peter S. Zammit, Charlotte A. Collins   +25 more
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Single Cell Analysis Identifies the miRNA Expression Profile of a Subpopulation of Muscle Precursor Cells Unique to Humans With Type 2 Diabetes

Frontiers in Physiology, 2018
MicroRNAs (miRNAs) take part in regulating central cellular processes such as differentiation and metabolism. We have previously shown that muscle progenitor cells derived from individuals with type 2 diabetes (T2DM) have a dysregulated miRNA profile. We
Tora I. Henriksen, Tora I. Henriksen, Sarah E. Heywood, Ninna S. Hansen, Bente K. Pedersen, Camilla C. Scheele, Camilla C. Scheele, Søren Nielsen   +7 more
doaj   +1 more source

Estrogen Regulates the Satellite Cell Compartment in Females

, 2019
Skeletal muscle mass, strength, and regenerative capacity decline with age, with many measures showing a greater deterioration in females around the time estrogen levels decrease at menopause.
Spangenburg, Espen E., Spangenburg, Espen, Collins, Brittany C., Xie, Ning, Cabelka, Christine A., Arpke, Robert W., Juppi, Hanna-Kaarina, Laakkonen, Eija K., Larson, Alexie A., Kovanen, Vuokko, Kyba, Michael, Sipilä, Sarianna, Baumann, Cory W., Nash, Nardina L., Lowe, Dawn A.   +14 more
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Hypoxia promotes proliferation and inhibits myogenesis in broiler satellite cells

Poultry Science
: Breast muscle myopathies in broilers compromise meat quality and continue to plague the poultry industry. Broiler breast muscle myopathies are characterized by impaired satellite cell (SC)-mediated repair, and localized tissue hypoxia and dysregulation
Usuk Jung, Minjeong Kim, Presley Dowker-Key, Simon Noë, Ahmed Bettaieb, Elizabeth Shepherd, Brynn Voy   +6 more
doaj   +1 more source