Results 41 to 50 of about 357,927 (309)

Human Pluripotent Stem Cell‐Derived Skeletal Muscle Organoid Model of Aging‐Induced Sarcopenia

Journal of Cachexia, Sarcopenia and Muscle
Background Sarcopenia is defined by the age‐related loss of muscle mass and function, with an impaired regenerative capacity of satellite cells (SCs).
Seongjun Park, Min‐Kyoung Shin, Dong Seok Jeong, Xin Yi Yeo, Yeo Jin Kim, Junaid Muhammad, Minju Kim, Seongeun Gu, Jeoung Eun Lee, Yunjin Park, Su Bin Lim, Ji Young Mun, Sangyong Jung, Dong Ryul Lee, Junghyun Jo   +14 more
doaj   +1 more source

Rapid generation of chromosome-specific alphoid DNA probes using the polymerase chain reaction [PDF]

, 1992
Non-isotopic in situ hybridization of chromosome-specific alphoid DNA probes has become a potent tool in the study of numerical aberrations of specific human chromosomes at all stages of the cell cycle. In this paper, we describe approaches for the rapid
A Gnirke, AHN Hopman, AR Mitchell, C Huxley, C Lengauer, Christoph Lengauer, D Pinkel, ED Green, EW Jabs, HF Willard, HF Willard, HF Willard, HM Rosenberg, Ian Dunham, J Anastasi, J Meyne, JE Koch, JS Waye, JS Waye, JS Waye, L Manuelidis, L Manuelidis, M Klever, P Emmerich, PJ Poddighe, PR Langer, S Popp, T Cremer, T Cremer, T Cremer, T Imai, T Maniatis, Terry Featherstone, Thomas Cremer   +33 more
core   +1 more source

The satellite stem cell architecture

2016 IEEE Symposium Series on Computational Intelligence (SSCI), 2016
Low-cost satellites continue to grow in popularity and capability, but have shown poor on-orbit performance to date. While traditional satellite missions have relied upon expensive fault prevention techniques, such as component screening, the use of radiation hardened components, and extensive test campaigns, low-cost missions must focus on fault ...
Erlank, AO, Bridges, Christopher
openaire   +3 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Crosstalk among canonical Wnt and Hippo pathway members in skeletal muscle and at the neuromuscular junction

Neural Regeneration Research
Skeletal muscles are essential for locomotion, posture, and metabolic regulation. To understand physiological processes, exercise adaptation, and muscle-related disorders, it is critical to understand the molecular pathways that underlie skeletal muscle ...
Said Hashemolhosseini, Lea Gessler
doaj   +1 more source

The Role of T Lymphocytes in Skeletal Muscle Repair From Traumatic and Contraction-Induced Injury

Frontiers in Physiology, 2018
Skeletal muscle is prone to damage from a range of stimuli, and initiates a robust repair process that requires the participation of immune cells. Among the more well characterized immune cells involved in muscle repair are those of the myeloid lineage ...
Michael R. Deyhle, Robert D. Hyldahl
doaj   +1 more source

Membrane glucocorticoid receptors are localised in the extracellular matrix and signal through the MAPK pathway in mammalian skeletal muscle fibres [PDF]

, 2015
A number of studies have previously proposed the existence of glucocorticoid receptors on the plasma membrane of many cell types including skeletal muscle fibres.
Dietmar Steverding, Eugene Akujuru, Feliciano Protasi, Gabriel Mutungi, Goldberg AL, Lewis Arthurton, Simona Boncompagni, Timothy Pearson, Wing SS   +8 more
core   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Global soil moisture bimodality in satellite observations and climate models [PDF]

, 2017
A new diagnostic metric based on soil moisture bimodality is developed in order to examine and compare soil moisture from satellite observations and Earth System Models.
de Jeu, RAM, Dolman, AJ, Miralles, Diego, Vilasa, L   +3 more
core   +5 more sources

CDK inhibitors for muscle stem cell differentiation and self-renewal

Journal of Physical Fitness and Sports Medicine, 2017
Regeneration of muscle is undertaken by muscle stem cell populations named satellite cells which are normally quiescent or at the G0 phase of the cell cycle.
Amrudha Mohan, Atsushi Asakura
doaj   +1 more source