Results 21 to 30 of about 486,419 (221)
Targeting Early Dementia: Using Lipid Cubic Phase Nanocarriers to Cross the Blood–Brain Barrier
Biomimetics, 2018 Over the past decades, a frequent co-morbidity of cerebrovascular pathology and Alzheimer’s disease has been observed. Numerous published studies indicate that the preservation of a healthy cerebrovascular endothelium can be an important therapeutic ...
Joseph S. D’Arrigo
doaj +1 more source
Method for identification of condition-associated public antigen receptor sequences [PDF]
eLife 2018;7:e33050, 2017 Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences.
arxiv +1 more source
Remodeling of HDL remnants generated by scavenger receptor class B type I [PDF]
Journal of Lipid Research, 2004 Scavenger receptor class B type I (SR-BI) mediates the selective transfer of cholesteryl ester from HDL to cells. We previously established that SR-BI overexpressed in livers of apolipoprotein A-I-deficient mice processes exogenous human HDL2 to incrementally smaller HDL particles.
Bela F. Asztalos +6 more
openaire +4 more sources
Frontiers in Microbiology, 2012 Enterovirus 71 (EV71) is one of the major causative agents of hand, foot and mouth disease (HFMD). Infection with EV71 is occasionally associated with severe neurological diseases such as acute encephalitis, acute flaccid paralysis and cardiopulmonary ...
Seiya eYamayoshi +2 more
doaj +1 more source
Soluble CD5 and CD6: Lymphocytic Class I Scavenger Receptors as Immunotherapeutic Agents
Cells, 2020 CD5 and CD6 are closely related signal-transducing class I scavenger receptors mainly expressed on lymphocytes. Both receptors are involved in the modulation of the activation and differentiation cell processes triggered by clonotypic antigen-specific ...
María Velasco-de Andrés +5 more
doaj +1 more source
Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I [PDF]
EMBO reports, 2002 The scavenger receptor class B type I (SR‐BI), which mediates selective cellular cholesterol uptake from high‐density lipoproteins (HDLs), plays a key role in reverse cholesterol transport. The orphan nuclear receptor liver receptor homolog 1 (LRH‐1) and SR‐BI are co‐expressed in liver and ovary, suggesting that LRH‐1 might control the expression of SR‐
Schoonjans, Kristina +7 more
openaire +4 more sources
Algebraic study of receptor-ligand systems: a dose-response analysis [PDF]
arXiv, 2022 The study of a receptor-ligand system generally relies on the analysis of its dose-response (or concentration-effect) curve, which quantifies the relation between ligand concentration and the biological effect (or cellular response) induced when binding its specific cell surface receptor.
arxiv
Scavenger Receptor Class B Type I Is a Plasma Membrane Cholesterol Sensor [PDF]
Circulation Research, 2013 Rationale: Signal initiation by the high-density lipoprotein (HDL) receptor scavenger receptor class B, type I (SR-BI), which is important to actions of HDL on endothelium and other processes, requires cholesterol efflux and the C-terminal transmembrane domain.
Wan Ru Lee +14 more
openaire +2 more sources
Medical Sciences, 2017 Owing to the complexity of neurodegenerative diseases, multiple cellular types need to be targeted simultaneously in order for a given therapy to demonstrate any major effectiveness.
Joseph S. D’Arrigo
doaj +1 more source
Lipoprotein Receptors Redundantly Participate in Entry of Hepatitis C Virus. [PDF]
PLoS Pathogens, 2016 Scavenger receptor class B type 1 (SR-B1) and low-density lipoprotein receptor (LDLR) are known to be involved in entry of hepatitis C virus (HCV), but their precise roles and their interplay are not fully understood. In this study, deficiency of both SR-
Satomi Yamamoto +14 more
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