Results 31 to 40 of about 22,858 (247)

The Class B Scavenger Receptors SR-BI and CD36 Are Receptors for Anionic Phospholipids [PDF]

Journal of Biological Chemistry, 1995
The specific recognition of anionic phospholipids in the outer leaflets of cell membranes and lipoproteins by cell surface receptors may play an important role in a variety of physiologic and pathophysiologic processes (e.g. recognition of damaged or senescent cells by the reticuloendothelial system or lipoprotein homeostasis).
A, Rigotti, S L, Acton, M, Krieger
openaire   +2 more sources

The thyromimetic T-0681 protects from atherosclerosis

Journal of Lipid Research, 2009
This report describes studies in hyperlipidemic New Zealand White (NZW) rabbits investigating the impact of the liver-selective thyromimetic T-0681 on lipoprotein metabolism and the development of atherosclerosis.
Ivan Tancevski, Andreas Wehinger, Egon Demetz, Julia Hoefer, Philipp Eller, Eva Huber, Ursula Stanzl, Kristina Duwensee, Kristina Auer, Wilfried Schgoer, Volker Kuhn, Catherine Fievet, Frans Stellaard, Mats Rudling, Bernhard Foeger, Josef R. Patsch, Andreas Ritsch   +16 more
doaj   +1 more source

Biomimetic Nanocarrier Targeting Drug(s) to Upstream-Receptor Mechanisms in Dementia: Focusing on Linking Pathogenic Cascades

Biomimetics, 2020
Past published studies have already documented that, subsequent to the intravenous injection of colloidal lipid nanocarriers, apolipoprotein (apo)A-I is adsorbed from the blood onto the nanoparticle surface.
Joseph S. D’Arrigo
doaj   +1 more source

Identification and characterization of scavenger receptor class B member 2 in Nile tilapia (Oreochromis niloticus)

Aquaculture Reports, 2021
The class B scavenger receptors (scarb) are members of important pattern recognition receptors which play key roles for host immune response to pathogen infection.
Zijiong Dong, Bingxi Li, Liting Wu, Yang Lei, Jianlin Chen, Liangliang Mu, Hairong Wu, Meng Chen, Bei Wang, Jianmin Ye, Fang Liang   +10 more
doaj   +1 more source

Myricetin ameliorates atherosclerosis in the low-density-lipoprotein receptor knockout mice by suppression of cholesterol accumulation in macrophage foam cells

Nutrition & Metabolism, 2019
Background Myricetin, a major flavonoid found in several foods including berries, grapes and wine, exhibited strong antioxidant potency, yet the effect on atherosclerosis is not fully understood.
Zhe Meng, Mengyu Wang, Junhui Xing, Yuzhou Liu, Haiyu Li   +4 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

β-Amyloid promotes accumulation of lipid peroxides by inhibiting CD36-mediated clearance of oxidized lipoproteins

Journal of Neuroinflammation, 2004
Background Recent studies suggest that hypercholesterolemia, an established risk factor for atherosclerosis, is also a risk factor for Alzheimer's disease.
Khan Tayeba, Medeiros Lea A, Tseng Anita A, Kunjathoor Vidya V, Moore Kathryn J   +4 more
doaj   +1 more source

Scavenger Receptor Class B Type I Is a Plasma Membrane Cholesterol Sensor [PDF]

Circulation Research, 2013
Rationale: Signal initiation by the high-density lipoprotein (HDL) receptor scavenger receptor class B, type I (SR-BI), which is important to actions of HDL on endothelium and other processes, requires cholesterol efflux and the C-terminal transmembrane domain.
Sonika, Saddar, Véronique, Carriere, Wan-Ru, Lee, Keiji, Tanigaki, Ivan S, Yuhanna, Sajesh, Parathath, Etienne, Morel, Manya, Warrier, Janet K, Sawyer, Robert D, Gerard, Ryan E, Temel, J Mark, Brown, Margery, Connelly, Chieko, Mineo, Philip W, Shaul   +14 more
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source