Results 1 to 10 of about 41,100 (154)

Use of Single-Chain Antibody Derivatives for Targeted Drug Delivery [PDF]

Molecular Medicine, 2016
Single-chain antibodies (scFvs), which contain only the variable domains of full-length antibodies, are relatively small molecules that can be used for selective drug delivery.
Yaghoub Safdari, Vahideh Ahmadzadeh, Masoumeh Khalili, Hossein Zarei Jaliani, Vahid Zarei, Vahid Erfani-Moghadam   +5 more
doaj   +3 more sources

Development of a recombinant biosimilar single-chain variable fragment antibody targeting human estrogen receptor α36 [PDF]

Research in Pharmaceutical Sciences
Background and purpose: The estrogen receptor alpha-36 (ER-α36) is an alternative splice variant of classical ER-α66 and is abundantly present in both ER-α66-positive and ER-α66-negative breast tumor cells.
Soodabeh Shafiee, Sedighe Kolivand, Neda Jalili, Mohammad Abedini, Mahboubeh Navabi, Yeganeh Talebkhan, Rezvan Esmaeili, Mohadeseh Haji Abdolvahab   +7 more
doaj   +2 more sources

Development of a Komagataella phaffii-based expression system for high-activity anti-SARS-CoV-2 neutralizing antibodies [PDF]

AMB Express
The growing need for rapid and cost-effective antibody production highlights the potential of Komagataella phaffii (syn. Pichia pastoris) as an alternative to mammalian systems.
Xueqin Liu, Qiaoli Lang, Nan Huang, Xiaoyan You, Yuchun Ding, Meng Wu, Liangpeng Ge, Xi Yang   +7 more
doaj   +2 more sources

Biomimetic nanoparticles coated with ScFv-modified macrophage membranes for siRNA delivery to relieve brain metastases of lung cancer [PDF]

BMC Biotechnology
Background In China, lung cancer stands as the leading cause of cancer-related deaths, often resulting in brain metastases (BM) that severely compromise patients’ quality of life and reduce survival outcomes. The delivery of drugs to the brain is further
Yuan Lu, Yan Qiao, Ting Wu, Yijing Zhang, JiaXin Shi, Jun Jiang   +5 more
doaj   +2 more sources

Development of a single-chain fragment variable fused-mutant HALT-1 recombinant immunotoxin against G12V mutated KRAS colorectal cancer cells [PDF]

PeerJ, 2021
Background KRAS oncogenes harboring codon G12 and G13 substitutions are considered gatekeeper mutations which drive oncogenesis in many cancers.
Michelle Yee Mun Teo, Jeremy Jeack Ceen Ng, Jung Yin Fong, Jung Shan Hwang, Adelene Ai-Lian Song, Renee Lay Hong Lim, Lionel Lian Aun In   +6 more
doaj   +2 more sources

Measles virus glycoprotein-based lentiviral targeting vectors that avoid neutralizing antibodies [PDF]

, 2012
Lentiviral vectors (LVs) are potent gene transfer vehicles frequently applied in research and recently also in clinical trials. Retargeting LV entry to cell types of interest is a key issue to improve gene transfer safety and efficacy.
Abel, Tobias, Brynza, Julia, Buchholz, Christian J., Kneissl, Sabrina, Rasbach, Anke, Schneider-Schaulies, Jürgen   +5 more
core   +12 more sources

Development of alkaline phosphatase-scFv and its use for one-step enzyme-linked immunosorbent assay for His-tagged protein detection

Open Life Sciences, 2022
A histidine (His)-tag is composed of six His residues and typically exerts little influence on the structure and solubility of expressed recombinant fusion proteins.
He Shuzhen, Xu Ruixian, Yi Huashan, Chen Zhixin, Chen Congjie, Li Qiang, Han Qinqin, Xia Xueshan, Song Yuzhu, Xu Junwei, Zhang Jinyang   +10 more
doaj   +1 more source

Recombinant expression of monovalent and bivalent anti-TNT-antibodies: Evaluation of different expression systems [PDF]

Journal of the Serbian Chemical Society, 2008
Monoclonal 11B3 anti-TNT (trinitrotoluene) antibody was expressed as a monovalent and bivalent form using different prokaryotic and eukaryotic expression systems.
Simonović Mladen, Zlatanović-Milošević Svetlana, Vrvić Miroslav M., Simonović Branislav   +3 more
doaj   +1 more source

Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer

OncoImmunology, 2022
Retargeting of T lymphocytes toward cancer cells by bispecific antibodies has demonstrated its therapeutic potential, with one such antibody approved for the treatment of acute lymphoblastic leukemia (blinatumomab) and several other in clinical trials ...
Antonio Tapia-Galisteo, Íñigo Sánchez Rodríguez, Oscar Aguilar-Sopeña, Seandean Lykke Harwood, Javier Narbona, Mariola Ferreras Gutierrez, Rocío Navarro, Laura Martín-García, Cesáreo Corbacho, Marta Compte, Javier Lacadena, Francisco J. Blanco, Patrick Chames, Pedro Roda-Navarro, Luis Álvarez-Vallina, Laura Sanz   +15 more
doaj   +1 more source

­­­Successful Application of Whole Cell Panning for Isolation of Phage Antibody Fragments Specific to Differentiated Gastric Cancer Cells [PDF]

Advanced Pharmaceutical Bulletin, 2019
Purpose: Generation of antibodies which potentially discriminate between malignant and healthy cells is an important prerequisite for early diagnosis and treatment of gastric cancer (GC).
Sepideh Nikfarjam, Mohammad Reza Tohidkia, Tayebeh Mehdipour, Ramin Soleimani, Ali Akbar Rahim Rahimi, Mohammad Nouri   +5 more
doaj   +1 more source