Results 51 to 60 of about 16,421 (302)

Kemampuan Argumentasi Ilmiah Calon Guru IPA melalui Pendekatan MIKiR selama Pandemi Covid-19

Journal of Natural Science and Integration, 2021
Since the Covid-19 pandemic, learning at the university or school level has implemented online learning. Even though the learning is conducted online, the teacher candidate's scientific argumentation skills must be trained.
D Diniya, Aldeva Ilhami, Ira Mahartika, Niki Dian Permana P, Om Prakash   +4 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Scientific arguments in policy-making [PDF]

Journal of Argumentation in Context, 2019
Abstract This paper focuses on the use of scientific insights for justifying decisions in policy-making. Because in policy-making the politician argues for a future course of action by pointing at its positive consequences, the burden of proof should concern not only the ...
Andone, C., Lomeli Hernández, J.A.
openaire   +4 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Internal and external scripts in computer-supported collaborative inquiry learning [PDF]

, 2007
We investigated how differently structured external scripts interact with learners’ internal scripts concerning individual knowledge acquisition in a Web-based collaborative inquiry learning environment.
Slotta, J. D., Kollar, Ingo, Fischer, Frank, Slotta, James D., Slotta, James D   +4 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A ESTRUTURA ARGUMENTATIVA E AS CARACTERÍSTICAS DOS ARGUMENTOS NO TEXTO QUE ABORDA A "NOVA TEORIASOBRE LUZ E CORES" DE ISAAC NEWTON

Ensaio Pesquisa em Educação em Ciências
O presente trabalho busca analisar a estrutura argumentativa e as características dos argumentos que aparecem no texto em que Isaac Newton descreve sua "Nova teoria sobre luz e cores", escrito em 1672.
Fábio Marineli, Lúcia Helena Sasseron
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Efektivitas Argument-Driven Inquiry untuk Meningkatkan Keterampilan Berargumentasi Ilmiah pada Materi Laju Reaksi

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2020
: The majority of problems occur in the learning science process are understanding the science concepts and using them to resolve problems; which making Indonesian students belong to low performers group.
Putu Anindita Widhiya Putri, Sri Rahayu, Fauziatul Fajaroh   +2 more
doaj   +1 more source