Results 61 to 70 of about 16,421 (302)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effects of Multi-Genre Digital Game-Based Instruction on Students’ Conceptual Understanding, Argumentation Skills, and Learning Experiences

IEEE Access, 2020
Studies have shown that although traditional instruction is effective in developing students’ conceptual understanding, it lacks in strengthening their thinking skills.
Chen-Yu Chen, Hui-Ju Huang, Chi-Jui Lien, Yu-Ling Lu   +3 more
doaj   +1 more source

THE EFFECT OF MODEL SCIENTIFIC INQUIRY TOWARD SCIENCE PROCESS SKILLS VIEWED FROM SCIENTIFIC ARGUMENTATION

, 2017
The purpose of this research is to determine: the result of students’ science process skill with using scientific inquiry learning model better than conventional learning, science process skill of students who have high average scientific argumentation ...
Meutia Kemala Putri
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

ABA: Argumentation Based Agents

, 2011
Many works have identified the potential benefits of using argumentation in multiagent settings, as a way to implement the capabilities of agents (eg. decision making, communication, negotiation) when confronted with specific multiagent problems. In this
Kakas, A., A. Kakas, Maudet, Nicolas, Amgoud, Leila, Kern-Isberner, Gabriele, Kern-Isbener, G;, L. Amgoud, Amgoud, L., Moraitis, Pavlos, G. Kern-Isberner, N. Maudet, Kakas, Antonis, P. Moraitis   +12 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Controversial issues in science education for functional scientific literacy: A case study of an implemented curriculum in Cyprus Science classrooms [PDF]

, 2011
This study has been designed to provide and interpret information from classroom based practice about the implementation of controversial issues in the science curriculum and relate it to the discussion about conceptual frameworks that situate ...
Lymbouridou, Chrystalla
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Science teachers’ views of scientific argumentation [PDF]

, 2018
Argümantasyon son yıllarda fen eğitimi araştırmalarında dikkat çeken alanlardan biridir. Ancak Türkiye'de fen eğitimi bağlamında yapılan çalışmaların çoğunlukla öğrencilerin ve öğretmen adaylarının argümantasyona yönelik özyeterlikleri ve algılarına ...
Namdar, Bahadır, Tüskan, İsmail Barış   +1 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source