Results 61 to 70 of about 7,545,871 (284)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Enhancing the Quality of Argumentation in School Science [PDF]

, 2004
The research reported in this paper focussed on the design of learning environments that support the teaching and learning of argumentation in a scientific context.
Sibel Erduran, Shirley Simon, Simon, S, Osborne, Jonathan, Erduran, S, Jonathan Osborne, Simon, Shirley, Osborne, J   +7 more
core   +1 more source

Argumentation and Knowledge Construction in Higher Education: A Vygotskian Perspective

Praxis & Saber
Empirical research indicates that the utilization of argumentation as an educational strategy fosters the acquisition of argumentation skills and disciplinary knowledge.
Ingrid González-Palta, Antonia Larrain
doaj   +1 more source

Guided Inquiry Learning Model Using Scientific Argumentation Activities to Improve Concept Understanding on Optical and Light

Jurnal Pendidikan Fisika Indonesia, 2023
Problem-solving ability, as one of the most important skills in the 21st century, must be improved to face the various challenges that exist. This is because solving problems requires mastery of the concepts underlying them.
R. Rahayu, S. Siswanto, C. A. Ramadhanti, B. Subali   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The impact of inquiry-based online learning with virtual laboratories on students’ scientific argumentation skills [PDF]

, 2023
Scientific argumentation is a higher-order thinking skill that is a major focus in education in the 21st century. This is a skill that plays an important role in knowledge construction which in reality is rarely implemented in science learning. The facts
Hendratmoko, Ahmad Fauzi, Widodo, Wahono, Sanjaya, I Gusti Made, Madlazim, Madlazim   +3 more
core  

The Influence of Concept Cartoon-Supported Issue of Demarcation-Based Scientific Argumentation on Argumentation Skills and Pseudoscientific Beliefs

, 2023
Studies have found that argumentation may lessen students' pseudoscientific beliefs. However, few studies of argumentation have been handled in the context of pseudoscientific beliefs. The purpose of the present study was to examine the influence of
Çavuş, Emine, Akgün, Abuzer, Duruk, Ümit   +2 more
core   +1 more source

Mastery of Scientific Argumentation on the Concept of Neutralization in Chemistry: A Malaysian Perspective

Malaysian Journal of Learning and Instruction, 2015
Purpose – Argumentative practices are central to science education, and have recently been emphasised to promote students’ reasoning skills and to develop student’s understanding of scientific concepts.
Lee Ling Heng, Johari Surif, Cher Hau Seng, Nor Hasniza Ibrahim   +3 more
doaj   +3 more sources

Differences in Scientific Argumentation Skills of Preservice Physics Teachers in Written and Oral Contexts: A Case Study of Video-Based Microteaching Learning

JPFT (Jurnal Pendidikan Fisika dan Teknologi)
This study aims to analyze the profile of scientific argumentation skills of preservice physics teachers in the context of written case studies and oral presentations through video-based microteaching learning.
Gunawan Gunawan, Lovy Herayanti
doaj   +1 more source

Development of Teaching Material Supplements Based on Socio Scientific Issues to Improve Students' Scientific Argumentation Ability

Journal of Innovative Science Education, 2023
The impact of the Covid-19 pandemic has touched every aspect of people's lives, including health and education. Because there is a lot of ignorance about prevention of Covid-19, it is necessary to have learning media that is easily accepted.
Khairul Anam, Siti Harnina Bintari, Parmin Parmin   +2 more
doaj   +1 more source