Results 61 to 70 of about 7,880,058 (288)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The impact of socio-scientific biology instruction on argumentation skills of preservice science teachers [PDF]

, 2018
The study was aimed to determine how instruction driven by socio-scientific biology instruction over a semester period influenced PST’s argumentation skills. One-group research design guided the study.
Kara, Yılmaz
core   +1 more source

The effect of socio-scientific issue (SSI) based discussion: A student-centred approach to the teaching of argumentation

SOTL in the South, 2020
Students should have the capability to argue about controversial science issues that are relevant to them and that impact society. These controversial issues, called socio-scientific issues (SSI), are influenced by social, ethical and moral norms.
Nahid Parween Anwar, Muhammad Abid Ali
doaj   +4 more sources

ARGUMENTATION SKILLS AND SELF-REGULATION OF STUDENTS USING PROBLEM BASED LEARNING COMBINED WITH DEBATES BASED ON SOCIOSCIENTIFIC ISSUES ON ENVIRONMENTAL CHANGE MATERIAL

EDUSAINS
Lack of self-confidence and self-monitoring to think, act and communicate scientifically are related to argumentation skills. This study aimed to determine differences: (1) students' argumentation skills, (2) students' self-regulation, (3) argumentation ...
Anie Yuni Widyastuti, Harlita Harlita, Meti Indrowati   +2 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Can the ISOCC learning model assisted microlearning improve information literacy and scientific argumentation skills?

Research and Development in Education
Background-This research assesses the effectiveness of implementing the ISOCC with ISOCC microlearning-assisted learning models in enhancing students’ information literacy and scientific argumentation skills.
Siti Nurul Hidayati, Muhammad Arif Mahdianur, Ernita Vika Aulia, Hasan Subekti, Ainus Salsabila, Fathul Zannah, Sabina Nwakaego Obi   +6 more
doaj   +1 more source

Diagnostic argumentation in teacher education: Making the case for justification, disconfirmation, and transparency

Frontiers in Education, 2022
Research on diagnosing in teacher education has primarily emphasized the accuracy of diagnostic judgments and has explained it in terms of factors such as diagnostic knowledge.
Elisabeth Bauer, Michael Sailer, Jan Kiesewetter, Martin R. Fischer, Frank Fischer   +4 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Profil Kemampuan Argumentasi Lisan Berbasis Socioscientific Issues Mahasiswa Pendidikan IPA pada Mata Kuliah Mikrobiologi

Pendipa, 2023
This study aims to determine the profile of students' oral argumentation skills based on Socioscientific Issues in the Microbiology course. This type of research is a descriptive study in order to obtain an overview of the quality of oral arguments of ...
Annisa Novianti Taufik, Liska Berlian, Atep Iman, Risa Tarisa   +3 more
doaj   +1 more source