Results 71 to 80 of about 7,545,871 (284)

Improving the Scientific Argumentation Skills of Physical Education Students Through the Argument Driven Inquiry Learning Model

Kinestetik : Jurnal Ilmiah Pendidikan Jasmani, 2023
Improving scientific argumentation skills through the application of the ADI learning model is the main goal of this research. Classroom action research through cycle 1 and cycle 2 was applied to achieve the research objectives. The procedure in this study consisted of five stages, namely: planning, implementing actions, observing, and reflecting.
null Dian Pujianto, null Yahya Eko Nopiyanto, null Syafrial, null Bayu Insanistyo   +3 more
openaire   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

The Application of Socioscientific Issues (SSI)-Based Learning to Develop Scientific Argumentation Skills in the Production of Bio-foam (Biodegradable Styrofoam) from Sugarcane Bagasse

SEAQIS Journal of Science Education
SSI-based learning focuses on the complex problems that develop throughout society. SSI holds significant implications for society, requiring students, as the future generation, to actively participate in dialogue, discussion, debate, and argumentation ...
Nurul Qomariah
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

PENERAPAN MODEL PEMBELAJARAN PEMBANGKIT ARGUMEN MENGGUNAKAN METODE SAINTIFIK UNTUK MENINGKATKAN KEMAMPUAN KOGNITIF DAN KETERAMPILAN BERARGUMENTASI SISWA

Jurnal Pendidikan Fisika Indonesia, 2014
Penelitian ini dilakukan untuk memperoleh gambaran tentang perbedaan peningkatan kemampuan kognitif dan keterampilan berargumentasi siswa yang mendapatkan pembelajaran fisika dengan model pembangkit argumen menggunakan metode saintifik dan tanpa ...
- Siswanto, I. Kaniawati, A. Suhandi
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Pembelajaran Inkuiri Terbimbing dengan Pendekatan STEM (Science, Technology, Engineering, Mathematics) untuk Pemahaman Konsep dan Keterampilan Argumentasi Siswa SMA pada Materi Laju Reaksi

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2020
: Argumentation is an important activity in scientific exploration which has been agreed as a major component in science education. Quality argumentation skills are formed with the understanding of concepts owned by students.
Astrid Kinantya Paramita, Yahmin Yahmin, I Wayan Dasna   +2 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Transparent Rational Decisions by Argumentation [PDF]

, 2013
There is a well-documented indication that several applications would benefit from the transparency afforded by argumentation to support decision-making where standard decision theory is not useful, e.g. in healthcare.
Craven, Robert, Fan, Xiuyi, Francesca Toni, Xiuyi Fan, Toni, Francesca, Robert Craven   +5 more
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