Frontiers in Immunology, 2015 Chemokines are a large family of structurally related chemoattractive cytokines, which have four conserved cysteines forming two disulfide bonds, and act through seven-transmembrane-spanning receptors coupled to heterotrimeric GTP-binding proteins (G-protein-coupled receptors).
Takashi eNagasawa
doaj +3 more sources
Association of SDF-1 and its receptor CXCR4 polymorphisms on the susceptibility of diabetic retinopathy in the Taiwanese population [PDF]
Frontiers in Genetics, 2023 Stromal cell-derived factor-1 (SDF-1) and its receptor CXC chemokine 4 (CXCR4) have been demonstrated to play critical roles in diabetic retinopathy (DR).
Shu-Yen Peng +17 more
doaj +2 more sources
Prognostic significance of plasma SDF-1 in acute ischemic stroke patients with diabetes mellitus: the CATIS trial [PDF]
Cardiovascular Diabetology, 2023 Background and objectives Evidence on the associations between baseline stromal cell-derived factor (SDF)-1 and clinical outcomes in acute ischemic stroke patients is lacking.
Shoujiang You +11 more
doaj +2 more sources
Impact of SDF-1 and AMD3100 on Hair Follicle Dynamics in a Chronic Stress Model [PDF]
BiomoleculesChronic stress is a common cause of hair loss, involving inflammatory responses and changes in cellular signaling pathways. This study explores the mechanism of action of the SDF-1/CXCR4 signaling axis in chronic stress-induced hair loss.
Yinglin Zhao +4 more
doaj +2 more sources
Stem cells migration during skeletal muscle regeneration - the role of Sdf-1/Cxcr4 and Sdf-1/ Cxcr7 axis [PDF]
Cell Adhesion & Migration, 2016 The skeletal muscle regeneration occurs due to the presence of tissue specific stem cells - satellite cells. These cells, localized between sarcolemma and basal lamina, are bound to muscle fibers and remain quiescent until their activation upon muscle ...
Brzoska, Edyta +12 more
core +5 more sources
Protection of stromal cell-derived factor-1 SDF-1/CXCL12 against proteases yields improved skin wound healing [PDF]
Frontiers in ImmunologySDF-1/CXCL12 is a unique chemotactic factor with multiple functions on various types of precursor cells, all carrying the cognate receptor CXCR4. Whereas individual biological functions of SDF-1/CXCL12 have been well documented, practical applications in
Rafaela Vaz Sousa Pereira +12 more
doaj +2 more sources
CXCL12/SDF-1 in IgG4-Related Disease. [PDF]
Front Pharmacol, 2021 Background: SDF-1/CXCL12 is a chemokine with pleiotropic functions in hematopoietic stem cell niche homeostasis, germinal center architecture, B cell maturation, neoangiogenesis, and fibrosis. Recently, the CXCL12/CXCR4/CXCR7 axis was associated with cancer metastasis and autoimmune diseases.
Capecchi R +9 more
europepmc +5 more sources
KLF9 inhibits the proliferation, invasion, and migration of renal cell carcinoma through the SDF‐1/CXCR4 axis [PDF]
Kaohsiung Journal of Medical Sciences, 2023 Altered Krüppel‐like factor 9 (KLF9) expression can regulate the progression of several cancers, including renal cell carcinoma (RCC). This study was conducted to investigate the role of KLF9 in the proliferation, invasion, and migration of RCC cells via
Peng Yu +6 more
doaj +2 more sources
Hypertension in Pregnancy, 2017 Objective: We aimed to compare the frequencies of stromal cell-derived factor-1 (SDF-1) 3′A and CXCR4 single-nucleotide polymorphisms (SNPs) and serum SDF-1 levels in patients with preeclampsia (PE).
Savas Karakus +6 more
doaj +5 more sources
The Potential of EMSA Eritin to Modulate T Cells (CD4+ and CD8+) in Balb/C Mice Model of Diabetes Mellitus [PDF]
Journal of Experimental Life Science, 2015 EMSA Eritin is a medicinal polyherbal contains with soy bean, coconut water and red rice extract. In several studies of this individual components have proven the potential to modulate lymphocyte cells that indirectly lowering blood glucose levels in ...
Ade MC Rohie, Muhaimin Rifa'i
doaj +4 more sources