Materials & Design, 2021 Background: SDF-1/CXCR4 axis plays a critical role in the mobilization and regeneration of host-derived cells. Little is known around the role of SDF-1 gene on bone regeneration.
Zhaoqi Sun +3 more
doaj +1 more source
Beneficial effects of reconstituted high-density lipoprotein (rHDL) on circulating CD34+ cells in patients after an acute coronary syndrome [PDF]
, 2017 Background: High-density lipoproteins (HDL) favorably affect endothelial progenitor cells (EPC). Circulating progenitor cell level and function are impaired in patients with acute coronary syndrome (ACS).
Alam, Mohammad Afaque +15 more
core +8 more sources
SDF-1 in myocardial repair [PDF]
Gene Therapy, 2012 Stem cell therapy for the prevention and treatment of cardiac dysfunction holds significant promise for patients with ischemic heart disease. Excitingly early clinical studies have demonstrated safety and some clinical feasibility, while at the same time studies in the laboratory have investigated mechanisms of action and strategies to optimize the ...
M S, Penn +3 more
openaire +2 more sources
SDF-1 promotes endochondral bone repair during fracture healing at the traumatic brain injury condition. [PDF]
PLoS ONE, 2013 The objective of this study was to investigate the role of stromal cell-derived factor-1 (SDF-1) and its receptor, CXCR4, on bone healing and whether SDF-1 contributes to accelerating bone repair in traumatic brain injury (TBI)/fracture model.Real-time ...
Xiaoqi Liu +6 more
doaj +1 more source
CXCL12 (SDF-1)/CXCR4 Pathway in Cancer [PDF]
Clinical Cancer Research, 2010 Abstract Chemokines, small proinflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. The chemokine CXCL12 [stromal cell-derived factor-1 (SDF-1)] binds primarily to CXC receptor 4 (CXCR4; CD184).
Beverly A, Teicher, Simon P, Fricker
openaire +2 more sources
Upregulation of stromal cell-derived factor 1 (SDF-1) is associated with macrophage infiltration in renal ischemia-reperfusion injury. [PDF]
PLoS ONE, 2014 Stromal cell-derived factor-1(SDF-1) is a chemotactic and angiogenic factor that mediates the repair of various tissues. As macrophages are important contributors to ischemic kidney injury, we examine the role of SDF-1 in a rodent model of ischemia ...
Xin Wan +6 more
doaj +1 more source
Controlled Delivery of Sdf-1 Alpha and Igf-1: Cxcr4(+) Cell Recruitment and Functional Skeletal Muscle Recovery [PDF]
, 2015 Therapeutic delivery of regeneration-promoting biological factors directly to the site of injury has demonstrated its efficacy in various injury models.
Farrar, Roger P. +6 more
core +1 more source
A Novel CXCR4 Targeting Protein SDF-1/54 as an HIV-1 Entry Inhibitor
Viruses, 2019 CXC chemokine receptor 4 (CXCR4) is a co-receptor for HIV-1 entry into target cells. Its natural ligand, the chemokine SDF-1, inhibits viral entry mediated by this receptor. However, the broad expression pattern of CXCR4 and its critical roles in various
Suiyi Tan +13 more
doaj +1 more source
Spinal Cord Injury Repair by Intrathecal Infusion of Stromal Cell-Derived Factor-1/CXC Chemokine Receptor 4 in a Rat Model [PDF]
, 2016 Background: Stromal cell-derived factor-1 (SDF-1)/CXC Chemokine receptor 4 (CXCR4) is an important cytokine, with multiple functions, which plays a crucial role in the recruitment of multiple stem cell types in the defect sites of central nervous system
Bajetto A +9 more
core +2 more sources
Chemokine-induced secretion of gelatinase B in primary human monocytes [PDF]
, 2001 Chemokines help control normal leukocyte trafficking as well as their infiltration into tissues during acute and chronic inflammation. Matrix metalloproteinases (MMPs) help support the extravasation and infiltration of leukocytes through limited ...
Brew K. +7 more
core +1 more source