Results 181 to 190 of about 25,897 (264)

Trichostatin A Sensitizes Tumor Cells to Apoptosis Induced by Soluble Trimeric TRAIL‐Expressing Human Mesenchymal Stromal Cells

Cancer Science, Volume 117, Issue 2, Page 456-467, February 2026.
Human mesenchymal stromal cells (MSCs) were engineered to secrete an isoleucine‐zippered soluble trimeric TRAIL (SCZT) and evaluated with trichostatin A (TSA) to overcome TRAIL resistance. TSA upregulated DR5 and amplified caspase‐8–dependent apoptosis in vitro; in vivo, tumor‐homing MSCs combined with TSA suppressed the growth of both TRAIL‐sensitive ...
Ryosuke Uchibori, Ken Ohmine, Keiya Ozawa   +2 more
wiley   +1 more source

The Model of Neutrophil Chemotaxis Participated by the Vascular Endothelial Glycocalyx. [PDF]

Int J Gen Med
Li P, Si Z, Shao Y, Wu W.
europepmc   +1 more source

Pharmacophore‐Based Identification and Molecular Characterization of Potent Neprilysin Inhibitors: Biochemical and Therapeutic Implications for Cardiovascular Diseases

Chemical Biology &Drug Design, Volume 107, Issue 2, February 2026.
Pharmacophore‐based virtual screening and molecular dynamics identified pentagalloylglucose and tannic acid as potent, non‐toxic neprilysin inhibitors. These natural compounds demonstrated strong binding affinity and stable interactions with the catalytic Zn2+ site, offering promising leads for cardiovascular drug development. ABSTRACT Neprilysin (NEP),
Chung‐Ting Kuo, Yi‐Chen Wu, Ji‐Min Li, Tz‐Chuen Ju, Tien‐Sheng Tseng   +4 more
wiley   +1 more source

Distinct Neurodegenerative Pathways in Two NBIA Subtypes: Inflammatory Activation in <i>C19orf12</i> but Not in <i>PANK2</i> Mutation Carriers. [PDF]

Cells
Skowrońska M, Cudna A, Pakuła B, Lebiedzińska-Arciszewska M, Janikiewicz J, Dobosz AM, Jakubek-Olszewska P, Wydrych A, Cwyl M, Dobrzyń A, Więckowski MR, Kurkowska-Jastrzębska I.   +11 more
europepmc   +1 more source

Sialyl Lewis^x Glycomimetics as E- and P-Selectin Antagonists Targeting Hyperinflammation. [PDF]

ACS Med Chem Lett
Joyal M, Simard RD, Maharsy W, Prévost M, Nemer M, Guindon Y.   +5 more
europepmc   +1 more source

T Cell Exhaustion in Hepatocellular Carcinoma: A Substantial Barrier in Immunotherapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Hepatocellular carcinoma (HCC), accounting for over 90% of primary liver cancers, remains a major global challenge for healthcare professionals. While immunotherapy has transformed the landscape of cancer treatment, its success is often limited by immune resistance, particularly through T cell exhaustion which remains a major barrier to ...
Kosar Nouri, Negar Asadollahei, Yasamin Haghir‐Sharif‐Zamini, Homeyra Seydi, Mahsa Salehi, Mehrnaz Mesdaghi, Mustapha Najimi, Massoud Vosough   +7 more
wiley   +1 more source

The Reciprocal Relationship Between Cell Adhesion Molecules and Reactive Oxygen Species. [PDF]

Cells
Al-Hadi M, Nikonenko AG, Sytnyk V.
europepmc   +1 more source

Prevention of In‐Stent Restenosis After PCI by Saponin Natural Products: Inhibition of Platelet Activation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Percutaneous coronary intervention (PCI) enables coronary revascularisation and restores haemodynamic stability but also carries risks of delayed complications including in‐stent restenosis (ISR), a chronic progressive disease with endovascular damage after PCI, which compromises the long‐term efficacy of PCI.
Xueli Lei, Chunlei Lv, Yu Zhang, Zhiyu Li, Hao Shen, Li Zhu   +5 more
wiley   +1 more source

Correction: Importance of Donor-Derived and Recipient-Derived Selectins in Cardiac Allograft Rejection.

J Am Soc Nephrol
Izawa A, Ueno T, Jurewicz M, Ito T, Tanaka K, Takahashi M, Ikeda U, Sobolev O, Fiorina P, Smith RN, Hynes RO, Abdi R.   +11 more
europepmc   +1 more source

Endothelial glycosylation and its emerging role in pulmonary vascular health and disease. [PDF]

Nat Commun
Nazaire V, Chandler KB.
europepmc   +1 more source