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Retinal Gatekeepers: Molecular Mechanism and Therapeutic Role of Cysteine and Selenocysteine [PDF]
BiomoleculesOxidative stress is a key contributor to retinal degeneration, as the retina is highly metabolically active and exposed to constant light stimulation. This review explores the crucial roles of cysteine and selenocysteine in redox homeostasis and retinal ...
Eleonora Maceroni +4 more
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Selenium supplementation of lactating dairy cows: effects on milk production and total selenium content and speciation in blood, milk and cheese [PDF]
Animal, 2008 Forty multiparous Holstein cows were used in a 16-week continuous design study to determine the effects of either selenium (Se) source, selenised yeast (SY) (derived from a specific strain of Saccharomyces cerevisiae CNCM I-3060) or sodium selenite (SS),
R.H. Phipps +5 more
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Novel selenoprotein neighborhoods suggest specialized biochemical processes [PDF]
mSystemsProkaryotic genomes encode selenoproteins sparsely, roughly one protein per 5,000. Finding novel selenoprotein families can expose unknown biological processes that are enabled, or at least enhanced, by having a selenium atom replace a sulfur atom in ...
Daniel H. Haft, Igor Tolstoy
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Antioxidants, 2019 The enzyme selenocysteine β-lyase (SCLY) was first isolated in 1982 from pig livers, followed by its identification in bacteria. SCLY works as a homodimer, utilizing pyridoxal 5’-phosphate as a cofactor, and catalyzing the specific ...
Lucia A. Seale
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Exploring the Antioxidant Roles of Cysteine and Selenocysteine in Cellular Aging and Redox Regulation [PDF]
BiomoleculesAging is a complex, universal biological process characterized by the progressive and irreversible decline of physiological functions across multiple organ systems.
Marta Pace +5 more
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Selenium persistency and speciation in the tissues of lambs following the withdrawal of dietary high-dose selenium-enriched yeast [PDF]
Animal, 2008 The objective was to determine the concentration of total selenium (Se) and the proportion of total Se comprised as selenomethionine (SeMet) and selenocysteine (SeCys) in post mortem tissues of lambs in the 6 weeks period following the withdrawal of a ...
D.T. Juniper +3 more
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Fermentation, 2023 Lactic acid bacteria (LAB) resist sodium selenite of concentrations greater than 100 mg/L in fermentation media. Selenium affects the growth rate, but once the microorganism absorbs selenium, this element is converted through a complex mechanism into ...
Meyli Claudia Escobar-Ramírez +5 more
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Selective selC-independent selenocysteine incorporation into formate dehydrogenases. [PDF]
PLoS ONE, 2013 The formate dehydrogenases (Fdh) Fdh-O, Fdh-N, and Fdh-H, are the only proteins in Escherichia coli that incorporate selenocysteine at a specific position by decoding a UGA codon.
Michael Zorn +4 more
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Deciphering the Role of Selenoprotein M
Antioxidants, 2023 Selenocysteine (Sec), the 21st amino acid, is structurally similar to cysteine but with a sulfur to selenium replacement. This single change retains many of the chemical properties of cysteine but often with enhanced catalytic and redox activity ...
Lance G. A. Nunes +4 more
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Sensors, 2020 The content of selenocysteine in cells has an important effect on a variety of human diseases, and the detection of selenocysteine by fluorescent sensors in vivo has shown many advantages. In order to further develop fast-reaction-time, good-selectivity,
Zongcheng Wang +6 more
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