Results 21 to 30 of about 20,702 (201)

Selenocysteine in Trypanosoma evansi: Identification of the Genes selb, selc, seld, pstk, seltryp and the Selenophosphate Synthetase Protein

Acta Protozoologica, 2021
Selenoproteins have been described in all three domains of life and their function has been mainly associated with oxidative stress defense.
Kaio Cesar Simiano Tavares, Maria Gabriela Casagrande Dambrós, André Saraiva Leão Antunes, Pietro Martin Danziato, Patricia Hermes Stoco, Aline Daiane Schlindwein, Renato Simões Moreira, Luiz Claudio Miletti   +7 more
doaj   +1 more source

Delivery of the selenoprotein thioredoxin reductase 1 to mammalian cells

Frontiers in Molecular Biosciences, 2022
Over-expression of genetically encoded thioredoxin reductase 1 (TrxR1) TrxR1 can be toxic to cells due to the formation of a truncated version of the enzyme. We developed a new mammalian cell-based model to investigate TrxR1 activity.
David E. Wright, Tarana Siddika, Ilka U. Heinemann, Patrick O’Donoghue   +3 more
doaj   +1 more source

Review

, 2020
The chalcogen elements oxygen, sulfur, and selenium are essential constituents of side chain functions of natural amino acids. Conversely, no structural and biological function has been discovered so far for the heavier and more metallic tellurium ...
Agh R, Arai K, Baskakov IV, Creighton TE, Dittmer K, Du Vigneaud V, Janeček J, Metanis N, Musiol HJ, Muttenthaler M, Nygard B, O'Donnell ME, Welch M, Yang F   +13 more
core   +1 more source

Expression of a catalytically inactive mutant form of glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility. [PDF]

, 2015
The selenoenzyme Gpx4 is essential for early embryogenesis and cell viability for its unique function to prevent phospholipid oxidation. Recently, the cytosolic form of Gpx4 was identified as an upstream regulator of a novel form of non-apoptotic cell ...
Aichler, M, Angeli, Jp, Buday, K, Conrad, M., Doll, S, Hoffard, N, Ingold, I, Roveri, Antonella, Tasdemir, A, Ursini, Fulvio, Walch, A, Wurst, W, Yefremova, E   +12 more
core   +1 more source

REPARATION : ribosome profiling assisted (re-)annotation of bacterial genomes [PDF]

, 2017
Prokaryotic genome annotation is highly dependent on automated methods, as manual curation cannot keep up with the exponential growth of sequenced genomes.
Giess, Adam, Jonckheere, Veronique, Menschaert, Gerben, Ndah, Elvis, Valen, Eivind, Van Damme, Petra   +5 more
core   +1 more source

Human selenoprotein P and S variant mRNAs with different numbers of SECIS elements and inferences from mutant mice of the roles of multiple SECIS elements [PDF]

Open Biology, 2016
Dynamic redefinition of the 10 UGAs in human and mouse selenoprotein P (Sepp1) mRNAs to specify selenocysteine instead of termination involves two 3′ UTR structural elements (SECIS) and is regulated by selenium availability. In addition to the previously
Sen Wu, Marco Mariotti, Didac Santesmasses, Kristina E. Hill, Janinah Baclaocos, Estel Aparicio-Prat, Shuping Li, John Mackrill, Yuanyuan Wu, Michael T. Howard, Mario Capecchi, Roderic Guigó, Raymond F. Burk, John F. Atkins   +13 more
doaj   +1 more source

Selenocysteine, pyrrolysine and the unique energy metabolism of methanogenic archaea [PDF]

, 2010
Methanogenic archaea are a group of strictly anaerobic microorganisms characterized by their strict dependence on the process of methanogenesis for energy conservation.
Rother, Michael, Krzycki, Joseph A.
core   +1 more source

Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation

Nature Communications, 2016
Specialized translation elongation factors (eEFSec and SelB) promote selenocysteine incorporation into proteins. Here, the authors report the structure of human eEFSec, examine its interactions with guanine nucleotides, and propose a non-canonical ...
Malgorzata Dobosz-Bartoszek, Mark H. Pinkerton, Zbyszek Otwinowski, Srinivas Chakravarthy, Dieter Söll, Paul R. Copeland, Miljan Simonović   +6 more
doaj   +1 more source

Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin

Antioxidants, 2022
Piperlongumine, a natural alkaloid substance extracted from the fruit of the long pepper (Piper longum Linn.), is known to inhibit the cytosolic thioredoxin reductase (TXNRD1 or TrxR1) and selectively kill cancer cells. However, the details and mechanism
Yijia Yang, Shibo Sun, Weiping Xu, Yue Zhang, Rui Yang, Kun Ma, Jie Zhang, Jianqiang Xu   +7 more
doaj   +1 more source

Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides

Biomedicines, 2018
Spider venoms are a rich source of insecticidal peptide toxins. Their development as bioinsecticides has, however, been hampered due to concerns about potential lack of stability and oral bioactivity.
Volker Herzig, Aline Dantas de Araujo, Kathryn P. Greenwood, Yanni K.-Y. Chin, Monique J. Windley, Youmie Chong, Markus Muttenthaler, Mehdi Mobli, Neil Audsley, Graham M. Nicholson, Paul F. Alewood, Glenn F. King   +11 more
doaj   +1 more source