Mechanisms Affecting the Biosynthesis and Incorporation Rate of Selenocysteine
Molecules, 2021 Selenocysteine (Sec) is the 21st non-standard proteinogenic amino acid. Due to the particularity of the codon encoding Sec, the selenoprotein synthesis needs to be completed by unique mechanisms in specific biological systems.
Jing-Jing Peng +4 more
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Novel sulfur and selenium containing bis-α-amino acids from 4-hydroxyproline [PDF]
, 2010 The synthesis of new substituted prolines carrying at C-4 a second α-amino acid residue is reported. The amino acid, l-cysteine or l-selenocysteine, is linked to the proline ring through the sulfur or the selenium atom, respectively.
CAPUTO, ROMUALDO +4 more
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Selenocysteine: the 21st amino acid [PDF]
Molecular Microbiology, 1991 SummaryGreat excitement was elicited in the field of selenium biochemistry in 1986 by the parallel discoveries that the genes encoding the selenoproteins glutathione peroxidase and bacterial formate dehydrogenase each contain an in‐frame TGA codon within their coding sequence.
A, Böck +6 more
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Selenium in biology: Facts and medical perspectives [PDF]
, 2000 Several decades after the discovery of setenium as an essential trace element in vertebrates approximately 20 eukaryotic and more than 15 prokaryotic selenoproteins containing the 21(st) proteinogenic amino acid, selenocysteine, have been identified ...
Brigelius-Flohé, Regina +5 more
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The single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene influences endothelial cell function : Interaction with selenium and fatty acids [PDF]
, 2013 © 2013 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH Verlag GmbH & Co.
Akbaraly +31 more
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Probing the Structure of [NiFeSe] Hydrogenase with QM/MM Computations [PDF]
, 2020 The geometry and vibrational behavior of selenocysteine [NiFeSe] hydrogenase isolated from Desulfovibrio vulgaris Hildenborough have been investigated using a hybrid quantum mechanical (QM)/ molecular mechanical (MM) approach. Structural models have been
Elghobashi-Meinhardt, Nadia Said +3 more
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Frontiers in Molecular Biosciences, 2023 Post-translational modifications (PTMs) can occur on almost all amino acids in eukaryotes as a key mechanism for regulating protein function. The ability to study the role of these modifications in various biological processes requires techniques to ...
Pearl Morosky +8 more
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ClinicsOBJECTIVE: The free radical theory of aging suggests that cellular oxidative damage caused by free radicals is a leading cause of aging. In the present study, we examined the effects of a well-known anti-oxidant amino acid derivative, selenocysteine, in ...
Jun-Sung Kim +2 more
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Probing pattern and dynamics of disulfide bridges using synthesis and NMR of an ion channel blocker peptide toxin with multiple diselenide bonds [PDF]
, 2016 Anuroctoxin (AnTx), a 35-amino-acid scorpion toxin containing four disulfide bridges, is a high affinity blocker of the voltage-gated potassium channel Kv1.3, but also blocks Kv1.2.
Bartok, Adam +9 more
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Tamoxifen-like metallocifens target thioredoxin system determining mitochondrial impairment leading to apoptosis in Jurkat cells [PDF]
, 2017 Tamoxifen-like metallocifens (TLMs) of the group-8 metals (Fe, Ru, and Os) show strong anti-proliferative activity on cancer cell lines resistant to apoptosis, owing to their unique redox properties. In contrast, the thioredoxin system, which is involved
Alberto Bindoli +9 more
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