Results 71 to 80 of about 14,518 (218)

UGA codon position-dependent incorporation of selenocysteine into mammalian selenoproteins [PDF]

, 2013
It is thought that the SelenoCysteine Insertion Sequence (SECIS) element and UGA codon are sufficient for selenocysteine (Sec) insertion. However, we found that UGA supported Sec insertion only at its natural position or in its close proximity in ...
Gladyshev, Vadim N., Hatfield, Dolph L., Lobanov, Alexei V., Turanov, Anton A.   +3 more
core   +1 more source

Selenoproteins and cardiovascular stress [PDF]

Thrombosis and Haemostasis, 2015
SummaryDietary selenium (Se) is an essential micronutrient that exerts its biological effects through its incorporation into selenoproteins. This family of proteins contains several antioxidant enzymes such as the glutathione peroxidases, redox-regulating enzymes such as thioredoxin reductases, a methionine sulfoxide reductase, and others.
Aaron H, Rose, Peter R, Hoffmann
openaire   +2 more sources

Halving the selenophosphate synthetase gene dose confers hypersensitivity to oxidative stress in Drosophila melanogaster [PDF]

, 2003
Several lines of evidence indicate that selenoproteins mainly act as cellular antioxidants. Here, we test this idea comparing the sensitivity to oxidative stress (paraquat and hydrogen peroxide) between wild type and heterozygous flies for the ...
Morey, Marta, Serras, Florenci, Corominas, Montserrat   +2 more
core   +1 more source

Stress and the Brain: An Emerging Role for Selenium

Frontiers in Neuroscience, 2021
The stress response is an important tool in an organism’s ability to properly respond to adverse environmental conditions in order to survive. Intense acute or chronic elevation of glucocorticoids, a class of stress hormone, can have deleterious ...
Daniel J. Torres, Naghum Alfulaij, Marla J. Berry   +2 more
doaj   +1 more source

Unraveling the Physicochemical Landscape of Organoselenium Compounds in Nanocarrier Systems

The Chemical Record, EarlyView.
Main nanocarriers employed to enhance the bioavailability and transport of organoselenium compounds. The image illustrates the key interaction forces that stabilize these organoselenium species in solution, enabling their application in drug delivery systems, catalysis, photoelectronic devices, and sensing technologies. In recent years, publications on
Romelly Eugenia Rojas Ramírez, Tielle Moraes de Almeida, Daiani Canabarro Leite, Gilson Zeni   +3 more
wiley   +1 more source

Selenium supplementation of lactating dairy cows: effects on milk production and total selenium content and speciation in blood, milk and cheese [PDF]

, 2008
Forty-multiparous Holstein cows were used in a 16-wk continuous design study to determine the effects of either selenium (Se) source, selenized yeast (SY) (derived from a specific strain of Saccharomyces cerevisiae CNCM I-3060 Sel-Plex®) or sodium ...
Bertin, Gérard, Grandison, Alistair Steven, Jones, Andrew Keith, Juniper, Darren Thomas, Phipps, Richard Hartley, Ramos-Morales, Eva   +5 more
core   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis [PDF]

, 2016
Selenium, an essential micronutrient known for its cancer prevention properties, is incorporated into a class of selenocysteine-containing proteins (selenoproteins).
Asara, John M., Brown, Kristin K., Chang, Christopher J., Chhangawala, Sagar, Cox, Andrew G., Dickinson, Bryan, Evason, Kimberley J., Gladyshev, Vadim N., Goessling, Wolfram, Heidel, Jerry, Houvras, Yariv, Hwang, Katie L., Kim, Andrew J., Lee, Byung Cheon, Lien, Evan C., Nissim, Sahar, Saunders, Diane, Tsomides, Allison, Yuan, Min   +18 more
core   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Needed for completion of the human genome: hypothesis driven experiments and biologically realistic mathematical models [PDF]

, 2004
With the sponsorship of ``Fundacio La Caixa'' we met in Barcelona, November 21st and 22nd, to analyze the reasons why, after the completion of the human genome sequence, the identification all protein coding genes and their variants remains a distant ...
Birney, Ewan, Brent, Michael, Crollius, Hugues Roest, Dermitzakis, Emmanouil, Guigo, Roderic, Pachter, Lior, Solovyev, Victor, Zhang, Michael Q.   +7 more
core   +1 more source