Results 101 to 110 of about 62,581 (273)

Inside and out: the activities of senescence in cancer. [PDF]

, 2014
The core aspect of the senescent phenotype is a stable state of cell cycle arrest. However, this is a disguise that conceals a highly active metabolic cell state with diverse functionality.
A Alimonti, A Chuprin, A Iannello, A Krtolica, A Lujambio, A Pribluda, A Shamma, A Takamura, A Ventura, AJ Millis, AM Leidal, Andrew R. J. Young, AR Davalos, ARJ Young, AV Knizhnik, AV Orjalo, AW Lin, B Quesnel, BD Chang, BJ Nickoloff, BJ Nickoloff, BJ Nickoloff, BY Lee, C Bavik, C Feig, C Gewinner, C Guerra, C Lu, C López-Otín, C Michaloglou, C Nardella, C Quijano, C-H Chan, C-H Wu, CA Schmitt, CB Harley, CE Burd, CP Martins, D Muñoz-Espín, DA Gewirtz, DA Gewirtz, DA Tuveson, DH Raulet, DJ Baker, DJ Baker, DM Feldser, E Elinav, E González-Suárez, E Lazzerini Denchi, ED Michelakis, F D'adda Di Fagagna, F D'adda Di Fagagna, F Janku, F Rodier, F Vazquez, FG Giancotti, G Bergers, G Mariño, G Mosieniak, G Willimsky, G Yang, H Braumüller, H Kondoh, H-K Lin, HT Kang, J Campisi, J Campisi, J Eyles, J Kaplon, J St-Pierre, J Zhu, J-G Ren, J-I Jun, J-P Coppé, J-P Coppé, JA Ewald, JC Acosta, JC Acosta, JC Acosta, JF Passos, JF Passos, JG Jackson, JR Dörr, JY Guo, JY Guo, K Rakhra, K-H Kim, KL Rudolph, KR Patel, L Hayflick, L Hayflick, L Hoenicke, L Qi, L Soucek, L-M Gerland, LG Baggetto, LL Scurr, M Braig, M Collado, M Collado, M Hoare, M Hoare, M Narita, M Puyol, M Qi, M Qi, M Reimann, M Serrano, M Storer, M Wall, MA Blasco, Masashi Narita, MS Song, MT Rosenfeldt, N Draoui, N Mizushima, N Müller-Hermelink, N Wajapeyee, N Wajapeyee, NE Sharpless, O Casanovas, O Moiseeva, P Jiang, P Sousa-Victor, Pedro A. Pérez-Mancera, PI Poulikakos, R Haq, R Lengagne, R Salama, RA Dickins, RA Greenberg, RH Poele te, RK Amaravadi, RK Amaravadi, RM Kortlever, RW Goehe, S Bonnet, S Campaner, S Courtois-Cox, S Goldstein, S Hubackova, S Parrinello, S Patschan, S Yoshimoto, SL Friedman, T Kuilman, T Kuilman, T Kuilman, T Schlomm, T-W Kang, U Herbig, V Krizhanovsky, VI Korolchuk, VJ Cristofalo, W Xue, WG Kaelin, WH Koppenol, X Qu, Y Chien, Y Wang, Z Chen, Z Yue, ZJ Yang   +162 more
core   +1 more source

Single-cell transcriptomics identifies senescence-associated secretory phenotype (SASP) features of testicular aging in human

Aging
The male reproductive system experiences degradation with age, predominantly impacting the testes. Testicular aging can result in failure to produce physiological testosterone levels, normal sperm concentrations, or both.
Junxian He, Jindong Li, Yanqing Li, Zhenhan Xu, Menghui Ma, Haicheng Chen, Peigen Chen, Linyan Lv, Xuejun Shang, Guihua Liu   +9 more
semanticscholar   +1 more source

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source

Brief guide to senescence assays using cultured mammalian cells

Molecules and Cells
: Cellular senescence is a crucial biological process associated with organismal aging and many chronic diseases. Here, we present a brief guide to mammalian senescence assays, including the measurement of cell cycle arrest, change in cellular morphology,
Eunseok Kang, Chanhee Kang, Young-Sam Lee, Seung-Jae V. Lee   +3 more
doaj   +1 more source

Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension. [PDF]

, 2020
Experimental ocular hypertension induces senescence of retinal ganglion cells (RGCs) that mimics events occurring in human glaucoma. Senescence-related chromatin remodeling leads to profound transcriptional changes including the upregulation of a subset ...
Jabari, Mary, Krawczyk, Michal, Nguyen Huu, Viet Anh, Palomino La Torre, Claudia, Rocha, Lorena Raquel, Skowronska-Krawczyk, Dorota, Weinreb, Robert N, Xu, Qianlan   +7 more
core  

The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology [PDF]

, 2019
Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune response to cancer. Thus, induction of their activity is the ultimate aim of all immunotherapies.
Dey, Mahua, Fetcko, Kaleigh, Henriquez, Mario, Huff, Wei X., Kwon, Jae Hyun   +4 more
core   +1 more source

Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature

European Journal of Medical Research
The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of senescent cells.
Shangkun Zhao, Zhi Qiao, R. Pfeifer, Hans-Christoph Pape, Keya Mao, Hai Tang, Bin Meng, Songfeng Chen, Hongjian Liu   +8 more
semanticscholar   +1 more source

SiO2‐CaOCME/Poly(Tetrahydrofuran)/Poly(Caprolactone) 3D‐Printed Scaffolds Drive Human‐Bone Marrow Stromal Cell Osteogenic Differentiation

Advanced Healthcare Materials, EarlyView.
3D printed hybrid scaffolds combining bioactive silica–calcium chemistry with elastic polymers guide human bone stem cells to form bone. The scaffolds support cell survival, organization, and invasion while releasing osteogenic ions. Together, architecture and composition drive bone‐specific gene expression, extracellular matrix organization, and ...
David R. Sory, Agathe C.M. Heyraud, Julian R. Jones, Sara M. Rankin   +3 more
wiley   +1 more source

The Regulation of Cellular Senescence in Cancer

Biomolecules
Cellular senescence is a stable state of cell cycle arrest caused by telomere shortening or various stresses. After senescence, cells cease dividing and exhibit many age-related characteristics. Unlike the halted proliferation of senescence cells, cancer
Xianhong Zhang, Yue Gao, Siyu Zhang, Yixiong Wang, Yitian Du, Shuailin Hao, Ting Ni   +6 more
doaj   +1 more source

The molecular basis for ethnic variation and histological subtype differences in prostate cancer. [PDF]

, 2013
Prostate cancer is a common malignancy among men in Western countries. Recently the morbidity and mortality of prostate cancer increase dramatically in several oriental countries including China.
Goldstein, Andrew S, Huang, Jiaoti, Zong, Yang   +2 more
core   +1 more source