Results 11 to 20 of about 62,581 (273)

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Frontiers in Cell and Developmental Biology, 2021
Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in response to various intrinsic and extrinsic stimuli, as well as developmental signals.
Ruchi Kumari, Parmjit Jat
doaj   +2 more sources

Overcoming the senescence‐associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer

Molecular Oncology, 2021
Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of suppressing tumour cell proliferation.
Cecilia R. Chambers, Shona Ritchie, Brooke A. Pereira, Paul Timpson   +3 more
doaj   +2 more sources

Colchicine Protects against Ethanol-Induced Senescence and Senescence-Associated Secretory Phenotype in Endothelial Cells

Antioxidants, 2023
Inflammaging is a potential risk factor for cardiovascular diseases. It results in the development of thrombosis and atherosclerosis. The accumulation of senescent cells in vessels causes vascular inflammaging and contributes to plaque formation and ...
Huakang Zhou, Dilaware Khan, Norbert Gerdes, Carsten Hagenbeck, Majeed Rana, Jan Frederick Cornelius, Sajjad Muhammad   +6 more
doaj   +2 more sources

The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy. [PDF]

Mol Cancer
Cellular senescence, characterized by partially irreversible cell cycle arrest, has a dual role in cancer progression via the senescence-associated secretory phenotype (SASP).
Cao L, Li K, Li Q, Tong Q, Wang Y, Huang L.   +5 more
europepmc   +2 more sources

Senescent-like microglia limit remyelination through the senescence associated secretory phenotype. [PDF]

Nat Commun
The capacity to regenerate myelin in the central nervous system diminishes with age. This decline is particularly evident in multiple sclerosis (MS), a chronic demyelinating disease.
Gross PS, Durán-Laforet V, Ho LT, Melchor GS, Zia S, Manavi Z, Barclay WE, Lee SH, Shults N, Selva S, Alvarez E, Plemel JR, Fu MM, Schafer DP, Huang JK.   +14 more
europepmc   +3 more sources

ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation. [PDF]

Nat Commun
Senescence-associated secretory phenotype (SASP) mediates the biological effects of senescent cells on the tissue microenvironment and contributes to ageing-associated disease progression.
Yang L, You J, Yang X, Jiao R, Xu J, Zhang Y, Mi W, Zhu L, Ye Y, Ren R, Min D, Tang M, Chen L, Li F, Liu P.   +14 more
europepmc   +2 more sources

EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

Nature Cancer, 2023
Immunotherapies that produce durable responses in some malignancies have failed in pancreatic ductal adenocarcinoma (PDAC) due to rampant immune suppression and poor tumor immunogenicity.
Loretah Chibaya, Katherine C. Murphy, Kelly D. DeMarco, Sneha Gopalan, Haibo Liu, Chaitanya N. Parikh, Y. Lopez-Diaz, Melissa Faulkner, Junhui Li, John P. Morris, Yu-jui Ho, Sachliv K. Chana, Janelle Simon, W. Luan, Amanda Kulick, E. de Stanchina, K. Simin, L. Zhu, T. Fazzio, S. Lowe, M. Ruscetti   +20 more
semanticscholar   +1 more source

The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?

Inflammation and Regeneration, 2022
Cellular senescence is a state of irreversible cell cycle arrest that can be induced by a variety of potentially oncogenic stimuli, including DNA damage.
Naoko Ohtani
semanticscholar   +1 more source

Senescent cells and macrophages: key players for regeneration? [PDF]

Open Biology, 2020
Over the last decade, our understanding of the physiological role of senescent cells has drastically evolved, from merely indicators of cellular stress and ageing to having a central role in regeneration and repair.
Sonia S. Elder, Elaine Emmerson
doaj   +1 more source

Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype

bioRxiv, 2022
Fibrogenesis is part of a normal protective response to tissue injury that can become irreversible and progressive, leading to fatal diseases. Senescent cells are a main driver of fibrotic diseases through their secretome, known as senescence-associated ...
Mate Maus, Vanessa López-Polo, Lidia Mateo, M. Lafarga, M. Aguilera, Eugenia De Lama, Kathleen Meyer, A. Solà, C. López-Martínez, I. López-Alonso, Marc Guasch-Piqueras, Fernanda Hernández-González, Selim Chaib, Miguel Rovira, Mayka Sánchez, R. Faner, À. Agustí, Rodrigo Diéguez-Hurtado, Sagrario Ortega, A. Manonelles, S. Engelhardt, Freddy Monteiro, C. Stephan-Otto Attolini, N. Prats, G. Albaiceta, J. Cruzado, M. Serrano   +26 more
semanticscholar   +1 more source