Results 51 to 60 of about 8,472,936 (269)

Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy

Frontiers in Oncology, 2018
In addition to promoting various forms of cell death, most conventional anti-tumor therapies also promote senescence. There is now extensive evidence that therapy-induced senescence (TIS) might be transient, raising the concern that TIS could represent ...
Tareq Saleh, Tareq Saleh, Liliya Tyutynuk-Massey, Liliya Tyutynuk-Massey, Emmanuel K. Cudjoe, Michael O. Idowu, Joseph W. Landry, Joseph W. Landry, David A. Gewirtz, David A. Gewirtz   +9 more
doaj   +1 more source

Isolation methodology is essential to the evaluation of the extracellular vesicle component of the senescence‐associated secretory phenotype

Journal of Extracellular Vesicles, 2021
A hallmark of senescence is the acquisition of an enhanced secretome comprising inflammatory mediators and tissue remodelling agents – the senescence‐associated secretory phenotype (SASP).
Ryan Wallis, Natasa Josipovic, Hannah Mizen, Arturo Robles‐Tenorio, Eleanor J. Tyler, Argyris Papantonis, Cleo L. Bishop   +6 more
doaj   +1 more source

QS2: Aberrant Breast Adipose Stromal Cell Biology In Women At High Risk For Developing Breast Cancer

Plastic and Reconstructive Surgery, Global Open, 2021
Purpose: Our laboratory studies contributions of breast adipose stromal cells (bASCs) to breast cancer initiation and progression. To date, most studies of ASC biology have focused on abdominal ASCs.
Mahsa Taskindoust, BS, Tingjun Xie, MD, Valery Nelson, MS, Bryanna Stukes, MHS, Scott Hollenbeck, MD, Robin Bachelder, PhD   +5 more
doaj   +1 more source

Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype

Nature Metabolism, 2023
Abstract Fibrogenesis is part of a normal protective response to tissue injury that can become irreversible and progressive, leading to fatal diseases. Senescent cells are a main driver of fibrotic diseases through their secretome, known as senescence-associated secretory phenotype (SASP). Here, we report that cellular senescence, and
Mate Maus, Vanessa López-Polo, Lidia Mateo, Miguel Lafarga, Mònica Aguilera, Eugenia De Lama, Kathleen Meyer, Anna Sola, Cecilia Lopez-Martinez, Ines López-Alonso, Marc Guasch-Piqueras, Fernanda Hernandez-Gonzalez, Selim Chaib, Miguel Rovira, Mayka Sanchez, Rosa Faner, Alvar Agusti, Rodrigo Diéguez-Hurtado, Sagrario Ortega, Anna Manonelles, Stefan Engelhardt, Freddy Monteiro, Camille Stephan-Otto Attolini, Neus Prats, Guillermo Albaiceta, Josep M. Cruzado, Manuel Serrano   +26 more
openaire   +5 more sources

Physiological hypoxia restrains the Senescence Associated Secretory Phenotype (SASP) via AMPK-mediated mTOR suppression. Vliet T et al

, 2021
Original images and blots of Physiological hypoxia restrains the Senescence Associated Secretory Phenotype (SASP) via AMPK-mediated mTOR suppression.
Restoring Organ Function by Means of Regenerative Medicine (REGENERATE), Demaria, Marco; id_orcid, Demaria, Marco, Damage and Repair in Cancer Development and Cancer Treatment (DARE)   +3 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype [PDF]

Aging Cell, 2012
SummaryCellular senescence suppresses cancer by arresting the proliferation of cells at risk for malignant transformation. Recently, senescent cells were shown to secrete numerous cytokines, growth factors, and proteases that can alter the tissue microenvironment and may promote age‐related pathology.
Remi-Martin, Laberge, Lili, Zhou, Melissa R, Sarantos, Francis, Rodier, Adam, Freund, Peter L J, de Keizer, Su, Liu, Marco, Demaria, Yu-Sheng, Cong, Pankaj, Kapahi, Pierre-Yves, Desprez, Robert E, Hughes, Judith, Campisi   +12 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Molecular Regulation of SASP in Cellular Senescence: Therapeutic Implications and Translational Challenges

Cells
Cellular senescence is a complex process that significantly contributes to the pathogenesis of various diseases, including cancer and neurodegenerative disorders.
Hubert Klepacki, Krystyna Kowalczuk, Natalia Łepkowska, Justyna Magdalena Hermanowicz   +3 more
doaj   +1 more source

Impact of senescence‐associated secretory phenotype and its potential as a therapeutic target for senescence‐associated diseases [PDF]

Cancer Science, 2017
“Cellular senescence” is a state in which cells undergo irreversible cell cycle arrest in response to a variety of cellular stresses. Once cells senesce, they are strongly resistant to any mitogens, including oncogenic stimuli. Therefore, cellular senescence has been assumed to be a potent anticancer mechanism.
Sugiko Watanabe, Shimpei Kawamoto, Naoko Ohtani, Eiji Hara   +3 more
openaire   +2 more sources