Results 41 to 50 of about 8,472,936 (269)
Redox control of senescence and age-related disease
Redox Biology, 2017 The signaling networks that drive the aging process, associated functional deterioration, and pathologies has captured the scientific community's attention for decades.
Akshaya Chandrasekaran +2 more
doaj +1 more source
Effect of menopausal hormone therapy on proteins associated with senescence and inflammation
Physiological Reports, 2020 Background Estrogen may inhibit cell senescence that contributes to age‐related disorders. This study determined the effects of menopausal hormone treatments on circulating levels of markers of cell senescence.
Laura Faubion +7 more
doaj +1 more source
Engineering mammalian cells to seek senescence-associated secretory phenotypes [PDF]
Journal of Cell Science, 2017 ABSTRACT Since the removal of senescent cells in model organisms has been linked to rejuvenation and increased lifespan, senotherapies have emerged to target senescent cells for death. In particular, interleukin-6 (IL6) is a prominent senescence-associated secretory phenotype (SASP) and, thus, seeking IL6 could potentially localize ...
Anam Qudrat, Janice Wong, Kevin Truong
openaire +2 more sources
Identification and study of a role for toll-like receptors in oncogene-induced senescence
, 2018 Oncogene-induced senescence (OIS) is a fail-safe mechanism activated to halt the proliferation of cells at risk of malignant transformation. It is a cell cycle arrest program of biological changes to the cell comprising of the activation of tumour ...
Hari, Priya
core +3 more sources
NF90 coordinately represses the senescence-associated secretory phenotype
Aging, 2012 A hallmark trait of cellular senescence is the acquisition of a senescence-associated secretory phenotype (SASP). SASP factors include cytokines and their receptors (IL-6, IL-8, osteoprotegerin, GM-CSF), chemokines and their ligands (MCP-1, HCC4), and oncogenes (Gro1 and Gro2), many of them encoded by mRNAs whose stability and translation are tightly ...
Kumiko, Tominaga-Yamanaka +5 more
openaire +2 more sources
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression [PDF]
Annual Review of Pathology: Mechanisms of Disease, 2010 Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescence-associated secretory phenotype (SASP ...
Jean-Philippe, Coppé +3 more
openaire +2 more sources
Cellular & Molecular Biology Letters, 2021 Background Various types of normal and cancer cells undergo senescence in response to carboplatin and paclitaxel, which are considered the gold standard treatments in ovarian cancer management.
Paweł Uruski +8 more
doaj +1 more source
Senescence and SASP Are Potential Therapeutic Targets for Ischemic Stroke
PharmaceuticalsAging is a known co-morbidity of ischemic stroke with its risk and severity increasing every year past 55+. While many of the current stroke therapies have shown success in reducing mortality, post-stroke morbidity has not seen the same substantial ...
Blake Ouvrier +2 more
doaj +1 more source
Journal of Ovarian Research, 2022 Background Clinical outcomes of cancer cell senescence are still elusive. Here, we reveal and compare pro-cancerous activity of spontaneously and drug-inducible senescent ovarian cancer cells.
Szymon Rutecki +9 more
doaj +1 more source
A Model for p38MAPK-Induced Astrocyte Senescence.
PLoS ONE, 2015 Experimental evidence indicates that aging leads to accumulation of senescent cells in tissues and they develop a secretory phenotype (also known as SASP, for senescence-associated secretory phenotype) that can contribute to chronic inflammation and ...
José C M Mombach +2 more
doaj +1 more source