Results 41 to 50 of about 50,933 (296)

The light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine [PDF]

, 2017
Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised ...
Cavarretta, Elena, Dal Sasso, Eleonora, Forte, Maurizio, Frati, Giacomo, Gerosa, Gino, Iop, Laura, Palmerio, Silvia, Peruzzi, Mariangela, Schirone, Leonardo, Sciarretta, Sebastiano   +9 more
core   +4 more sources

Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype [PDF]

Scientific Reports, 2018
AbstractProcesses that have been linked to aging and cancer include an inflammatory milieu driven by senescent cells. Senescent cells lose the ability to divide, essentially irreversibly, and secrete numerous proteases, cytokines and growth factors, termed the senescence-associated secretory phenotype (SASP).
Wiley, Christopher D, Schaum, Nicholas, Alimirah, Fatouma, Lopez-Dominguez, Jose Alberto, Orjalo, Arturo V, Scott, Gary, Desprez, Pierre-Yves, Benz, Christopher, Davalos, Albert R, Campisi, Judith   +9 more
openaire   +4 more sources

The Senescence-Associated Secretory Phenotype Promotes Benign Prostatic Hyperplasia

The American Journal of Pathology, 2014
Benign prostatic hyperplasia (BPH) is characterized by increased tissue mass in the transition zone of the prostate, which leads to obstruction of urine outflow and considerable morbidity in a majority of older men. Senescent cells accumulate in human tissues, including the prostate, with increasing age.
Vital, Paz, Castro, Patricia, Tsang, Susan, Ittmann, Michael   +3 more
openaire   +2 more sources

Mettl14-driven senescence-associated secretory phenotype facilitates somatic cell reprogramming

Stem Cell Reports, 2022
The METTL3-METTL14 complex, the "writer" of N6-methyladenosine (m6A), plays an important role in many biological processes. Previous studies have shown that Mettl3 overexpression can increase the level of m6A and promote somatic cell reprogramming. Here, we demonstrate that Mettl14, another component of the methyltransferase complex, can significantly ...
Chenxiang Xi, Jiatong Sun, Xiaocui Xu, You Wu, Xiaochen Kou, Yanhong Zhao, Jiacheng Shen, Yu Dong, Kang Chen, Zhongqu Su, Dan Liu, Wen Ye, Yingdong Liu, Ran Zhang, Yiliang Xu, Hong Wang, Lujiang Hao, Li Wu, Shaorong Gao   +18 more
openaire   +2 more sources

Primary high-grade serous ovarian cancer cells are sensitive to senescence induced by carboplatin and paclitaxel in vitro

Cellular & Molecular Biology Letters, 2021
Background Various types of normal and cancer cells undergo senescence in response to carboplatin and paclitaxel, which are considered the gold standard treatments in ovarian cancer management.
Paweł Uruski, Agnieszka Sepetowska, Corinna Konieczna, Martyna Pakuła, Michał Wyrwa, Akylbek Tussupkaliyev, Andrzej Tykarski, Justyna Mikuła-Pietrasik, Krzysztof Książek   +8 more
doaj   +1 more source

QS2: Aberrant Breast Adipose Stromal Cell Biology In Women At High Risk For Developing Breast Cancer

Plastic and Reconstructive Surgery, Global Open, 2021
Purpose: Our laboratory studies contributions of breast adipose stromal cells (bASCs) to breast cancer initiation and progression. To date, most studies of ASC biology have focused on abdominal ASCs.
Mahsa Taskindoust, BS, Tingjun Xie, MD, Valery Nelson, MS, Bryanna Stukes, MHS, Scott Hollenbeck, MD, Robin Bachelder, PhD   +5 more
doaj   +1 more source

HMGB2 holds the key to the senescence-associated secretory phenotype [PDF]

Journal of Cell Biology, 2016
The senescence-associated secretory phenotype (SASP) is a hallmark of senescence with an important physiological impact, but how it is established is unclear. In this issue, Aird et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201608026) describe how chromatin-bound HMGB2 fine tunes SASP expression by avoiding heterochromatin spreading.
Guerrero a, Gil, J
openaire   +4 more sources

Pro-cancerogenic effects of spontaneous and drug-induced senescence of ovarian cancer cells in vitro and in vivo: a comparative analysis

Journal of Ovarian Research, 2022
Background Clinical outcomes of cancer cell senescence are still elusive. Here, we reveal and compare pro-cancerous activity of spontaneously and drug-inducible senescent ovarian cancer cells.
Szymon Rutecki, Paulina Szulc, Martyna Pakuła, Paweł Uruski, Artur Radziemski, Eryk Naumowicz, Rafał Moszyński, Andrzej Tykarski, Justyna Mikuła-Pietrasik, Krzysztof Książek   +9 more
doaj   +1 more source

Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence [PDF]

, 2019
The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of aging.
Diekman, Brian O., Gudkov, Andrei V., Hall, Brandon M., Krishnamurthy, Janakiraman, Liu, Jie-Yu, Parker, Joel S., Sessions, Garrett A., Sharpless, Norman E., Sorrentino, Jessica A., Souroullas, George P.   +9 more
core   +3 more sources

Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype [PDF]

Aging Cell, 2012
SummaryCellular senescence suppresses cancer by arresting the proliferation of cells at risk for malignant transformation. Recently, senescent cells were shown to secrete numerous cytokines, growth factors, and proteases that can alter the tissue microenvironment and may promote age‐related pathology.
Remi-Martin, Laberge, Lili, Zhou, Melissa R, Sarantos, Francis, Rodier, Adam, Freund, Peter L J, de Keizer, Su, Liu, Marco, Demaria, Yu-Sheng, Cong, Pankaj, Kapahi, Pierre-Yves, Desprez, Robert E, Hughes, Judith, Campisi   +12 more
openaire   +2 more sources