Results 41 to 50 of about 31,992 (113)

Redox metabolism in cell senescence: focusing on contributions from the metabolomic field

Frontiers in Molecular Biosciences
Cell senescence is triggered by stressful stimuli, including telomere attrition, genotoxic agents, and strong mitogenic signals. This state is characterized by proliferation arrest and acquisition of a senescence-associated secretory phenotype. Senescent
Eliana Chacón, Guillermo Grünwaldt, Inés Marmisolle, Jennyfer Martínez, Celia Quijano   +4 more
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Corrigendum: The Paradoxical Role of Cellular Senescence in Cancer

Frontiers in Cell and Developmental Biology, 2021
Jing Yang, Jing Yang, Mengmeng Liu, Mengmeng Liu, Dongchun Hong, Dongchun Hong, Musheng Zeng, Xing Zhang   +7 more
doaj   +1 more source

Cellular senescence of renal tubular epithelial cells in acute kidney injury

Cell Death Discovery
Cellular senescence represents an irreversible state of cell-cycle arrest during which cells secrete senescence-associated secretory phenotypes, including inflammatory factors and chemokines.
Juan Chen, Huhai Zhang, Xiangling Yi, Qian Dou, Xin Yang, Yani He, Jia Chen, Kehong Chen   +7 more
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The interplay between obesity, immunosenescence, and insulin resistance

Immunity & Ageing
Obesity, which is the accumulation of fat in adipose tissue, has adverse impacts on human health. Obesity-related metabolic dysregulation has similarities to the metabolic alterations observed in aging.
Ghazaleh Shimi, Mohammad Hassan Sohouli, Arman Ghorbani, Azam Shakery, Hamid Zand   +4 more
doaj   +1 more source

A narrative review of therapy-induced senescence in cancer: mechanisms, immune interplay, and therapeutic opportunities

Journal of the Egyptian National Cancer Institute
Therapy-induced senescence (TIS) has emerged as a pivotal mechanism in cancer therapy, exerting both tumor-suppressive and tumor-promoting effects.
Henry Sutanto, Alfan Ahkami, Deasy Fetarayani, Pradana Zaky Romadhon   +3 more
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Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications

MedComm – Oncology
Cellular senescence plays a complex, dual role in cancer. Senescent cells induce tumor suppression through cell cycle arrest and immune response activation but also secrete pro‐inflammatory factors via the senescence‐associated secretory phenotype (SASP),
Huajie Mao, Wanning Liu, Yuanyuan Su, Yuxuan Ma, Xiaodi Zhao, Yuanyuan Lu   +5 more
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Collaboration networks and knowledge structure in cancer and cellular senescence research (2000–2025): a bibliometric perspective

Discover Oncology
Cancer is a leading cause of death worldwide, posing substantial public health challenges. Cellular senescence, a stress-induced cell fate characterized by stable cell-cycle arrest and a hypersecretory state, plays dual roles in tissue repair and tumor ...
He Zhu, Shuangjia Pan, Yujia Zhou, Baozhu Yi, Yuqing Jing, Luyi Ruan, Lingxiao Huang, Xueqiong Zhu   +7 more
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Cycloastragenol attenuates osteoarthritis by restoring chondrocyte senescence via the NRF2/NF-κB signaling axis

Scientific Reports
Osteoarthritis (OA) involves oxidative stress-induced chondrocyte senescence and extracellular matrix (ECM) dysregulation, yet disease-modifying therapies remain elusive.
Shuhao Zhang, Yanlong Zou, Jundong Long, Yufan Wang, Jian Chen, Miao Teng   +5 more
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Cellular senescence in cancer immunology and potential therapeutic strategy

Frontiers in Oncology
Cellular senescence represents a state of stable, often irreversible cell cycle arrest. Unlike apoptosis, senescent cells (SCs) remain metabolically active and engage in robust secretory activity, most notably through the senescence-associated secretory ...
Xiao-Dan Qian, Li-De Tao, Li-Hong Zhang, An-Lai Ji, Lei Wang, Muhammad Mudasar Iqbal, Yi Luo   +6 more
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Cellular Senescence and Immunosenescence in Melanoma: Insights From the Tumor Microenvironment

Cancer Medicine
Background Melanoma is one of the most immunogenic malignancies, yet resistance to immune checkpoint inhibitors (ICIs) remains a major obstacle to durable therapeutic success.
Lihua Xiong, Jian Cheng
doaj   +1 more source