The Senescence-Associated Secretory Phenotype Promotes Benign Prostatic Hyperplasia [PDF]
The American Journal of Pathology, 2014 Benign prostatic hyperplasia (BPH) is characterized by increased tissue mass in the transition zone of the prostate, which leads to obstruction of urine outflow and considerable morbidity in a majority of older men. Senescent cells accumulate in human tissues, including the prostate, with increasing age.
Vital, Paz +3 more
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NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype [PDF]
Inflammation ResearchAbstract Background Senescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory factors referred to as senescence-associated secretory phenotype (SASP), some of which are produced by the NLRP3 inflammasome.
Muela-Zarzuela, Inés +12 more
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Basal Cells Contribute to Pulmonary Fibrosis via SP1‐Mediated Senescence‐Associated Secretory Phenotype [PDF]
The Clinical Respiratory JournalIdiopathic pulmonary fibrosis is a progressive interstitial lung disease with limited treatment options and poor prognosis. Increasing evidence suggests that airway epithelial remodeling contributes to disease pathogenesis, yet the role of basal cells ...
Xiaoyan Wang +5 more
doaj +2 more sources
Altered Senescence-Associated Secretory Phenotype of Human Osteoblasts from Patients with Osteoporosis Enhances Endothelial Cell Migration and Proliferation In Vitro [PDF]
BiologyOsteoporosis (OP) is a highly prevalent age-associated inflammatory bone disease that remains underdiagnosed and undertreated despite its substantial global burden.
Lisa Oezel +9 more
doaj +2 more sources
Targeting the Senescence-Associated Secretory Phenotype
, 2019 Age is the single-most significant variable in the loss of normal tissue homeostasis resulting in degenerative disease. Increasing with age is a slight, but significant rise in pro-inflammatory factors in the absence of detectable infection, also known as “sterile inflammation”.
Perrott, Kevin M
openaire +2 more sources
Targeting the senescence-associated secretory phenotype in cancer therapy
, 2023 The current main strategy in the treatment of cancer is to target rapidly dividing cells, which induces DNA damage and promotes senescence in both cancerous and non-malignant cells alike.
Niamh Kerslake (16845207)
core +5 more sources
Senescence And The Senescence Associated Secretory Phenotype In Salivary Hypofunction [PDF]
Cellular senescence, a triggered permanent cycle arrest, occurs with aging and is a component of many aging-related diseases. Triggers for senescence may include pathways involving DNA damage, telomere dysfunction, release of reactive oxygen species, and
Jean-Baptiste, Quetsia
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CXCL5-CXCR2 signaling is a senescence-associated secretory phenotype in preimplantation embryos [PDF]
, 2022 Pregnancy rate of women decreases with age due to declining quality of oocytes and embryos. However, there is no established method to improve pregnancy rate in aging women.
KAWAMURA, Kazuhiro +5 more
core +2 more sources
Journal of Functional Biomaterials, 2022 Senescent cells accumulate in aged organisms and promote the progression of age-related diseases including cataracts. Therefore, we aimed to study the therapeutic effects of senescence-targeting drugs on cataracts.
Yinhao Wang +5 more
doaj +1 more source
Growth differentiation factor‐15 is associated with age‐related monocyte dysfunction
Aging Medicine, 2021 Objective Age‐associated decreases in immune functions are precipitated by a variety of mechanisms and affect nearly every immune cell subset. In myeloid cells, aging reduces numbers of phagocytes and impairs their functional abilities, including antigen
Brandt D. Pence +2 more
doaj +1 more source