Results 21 to 30 of about 8,942,313 (272)

CXCL5-CXCR2 signaling is a senescence-associated secretory phenotype in preimplantation embryos [PDF]

, 2022
Pregnancy rate of women decreases with age due to declining quality of oocytes and embryos. However, there is no established method to improve pregnancy rate in aging women.
KAWAMURA, Kazuhiro, KAWASHIMA, Ikko, SATO, Yorino, MATSUBARA, Kazuei, KAWAGOE, Yuta, OKAMOTO, Naoki   +5 more
core   +2 more sources

COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins. [PDF]

, 2020
COPD-derived fibroblasts have increased cellular senescence. Senescent cell accumulation can induce tissue dysfunction by their senescence-associated secretory phenotype (SASP).
Heijink IH, de Vries M, Woldhuis RR, Oliver BGG, van den Berge M, Timens W, Brandsma C-A, Heijink, Irene H, Timens, Wim; id_orcid, de Vries, Maaike, van den Berge, Maarten; id_orcid, Woldhuis, Roy R; id_orcid, Brandsma, Corry-Anke; id_orcid, Oliver, Brian G G   +13 more
core   +4 more sources

Suppression of p16 alleviates the senescence-associated secretory phenotype

Aging, 2021
Oncogene-induced senescence (OIS) is characterized by increased expression of the cell cycle inhibitor p16, leading to a hallmark cell cycle arrest. Suppression of p16 in this context drives proliferation, senescence bypass, and contributes to tumorigenesis.
Buj, Raquel, Leon, Kelly E., Anguelov, Marlyn A., Aird, Katherine M.   +3 more
openaire   +2 more sources

The Controversial Role of Senescence-Associated Secretory Phenotype (SASP) in Cancer Therapy [PDF]

Molecular Cancer
Qiang Tong, Kaixiu Li
exaly   +2 more sources

Overcoming the senescence‐associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer

Molecular Oncology, 2021
Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of suppressing tumour cell proliferation.
Cecilia R. Chambers, Shona Ritchie, Brooke A. Pereira, Paul Timpson   +3 more
doaj   +1 more source

Senescent cells and macrophages: key players for regeneration? [PDF]

Open Biology, 2020
Over the last decade, our understanding of the physiological role of senescent cells has drastically evolved, from merely indicators of cellular stress and ageing to having a central role in regeneration and repair.
Sonia S. Elder, Elaine Emmerson
doaj   +1 more source

The Paradoxical Role of Cellular Senescence in Cancer

Frontiers in Cell and Developmental Biology, 2021
Cellular senescence occurs in proliferating cells as a consequence of various triggers including telomere shortening, DNA damage, and inappropriate expression of oncogenes.
Jing Yang, Jing Yang, Mengmeng Liu, Mengmeng Liu, Dongchun Hong, Dongchun Hong, Musheng Zeng, Xing Zhang   +7 more
doaj   +1 more source

Physiological hypoxia restrains the Senescence Associated Secretory Phenotype (SASP) via AMPK-mediated mTOR suppression. Vliet T et al

, 2021
Original images and blots of Physiological hypoxia restrains the Senescence Associated Secretory Phenotype (SASP) via AMPK-mediated mTOR suppression.
Restoring Organ Function by Means of Regenerative Medicine (REGENERATE), Demaria, Marco; id_orcid, Demaria, Marco, Damage and Repair in Cancer Development and Cancer Treatment (DARE)   +3 more
core   +1 more source

Senescence: Definition, mechanisms of occurence and detection in tissues [PDF]

Medicinski Podmladak
A cellular senescence represents a state, which is defined as a stable blockage of the cellular cycle in the G1 phase, as an answer to multiple triggers and their qualitative and quantitative characteristics. Alongside the blockage of the cellular cycle,
Mijajlović Vladimir, de Luka Silvio, Manojlović-Gačić Emilija   +2 more
doaj   +1 more source

Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype

Frontiers in Endocrinology, 2022
Cellular senescence is a stress or damage response by which a cell adopts of state of essentially permanent proliferative arrest, coupled to the secretion of a number of biologically active molecules. This senescence-associated secretory phenotype (SASP) underlies many of the degenerative and regenerative aspects of cellular senescence - including ...
Chisaka Kuehnemann, Chisaka Kuehnemann, Kang-Quan Hu, Kayla Butera, Sandip K. Patel, Joanna Bons, Birgit Schilling, Cristina Aguayo-Mazzucato, Christopher D. Wiley   +8 more
openaire   +3 more sources