Results 21 to 30 of about 32,141 (252)
HMGB2 holds the key to the senescence-associated secretory phenotype [PDF]
Journal of Cell Biology, 2016 The senescence-associated secretory phenotype (SASP) is a hallmark of senescence with an important physiological impact, but how it is established is unclear. In this issue, Aird et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201608026) describe how chromatin-bound HMGB2 fine tunes SASP expression by avoiding heterochromatin spreading.
Guerrero a, Gil, J
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Suppression of p16 alleviates the senescence-associated secretory phenotype
Aging, 2021 Oncogene-induced senescence (OIS) is characterized by increased expression of the cell cycle inhibitor p16, leading to a hallmark cell cycle arrest. Suppression of p16 in this context drives proliferation, senescence bypass, and contributes to tumorigenesis.
Buj, Raquel +3 more
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Communications Biology, 2022 Type-2 diabetic adipose tissue impairs transient senescence during wound healing with expression of different components of the senescence-associated secretory phenotype (SASP), and this is associated with deteriorated wound healing.
Arisa Kita +8 more
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Molecular Oncology, 2021 Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of suppressing tumour cell proliferation.
Cecilia R. Chambers +3 more
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Senescent cells and macrophages: key players for regeneration? [PDF]
Open Biology, 2020 Over the last decade, our understanding of the physiological role of senescent cells has drastically evolved, from merely indicators of cellular stress and ageing to having a central role in regeneration and repair.
Sonia S. Elder, Elaine Emmerson
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The Paradoxical Role of Cellular Senescence in Cancer
Frontiers in Cell and Developmental Biology, 2021 Cellular senescence occurs in proliferating cells as a consequence of various triggers including telomere shortening, DNA damage, and inappropriate expression of oncogenes.
Jing Yang +7 more
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Senescence: Definition, mechanisms of occurence and detection in tissues [PDF]
Medicinski PodmladakA cellular senescence represents a state, which is defined as a stable blockage of the cellular cycle in the G1 phase, as an answer to multiple triggers and their qualitative and quantitative characteristics. Alongside the blockage of the cellular cycle,
Mijajlović Vladimir +2 more
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Frontiers in Endocrinology, 2022 Cellular senescence is a stress or damage response by which a cell adopts of state of essentially permanent proliferative arrest, coupled to the secretion of a number of biologically active molecules. This senescence-associated secretory phenotype (SASP) underlies many of the degenerative and regenerative aspects of cellular senescence - including ...
Chisaka Kuehnemann +8 more
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Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype [PDF]
Journal of Proteome Research, 2020 Primary diploid cells exit the cell cycle in response to exogenous stress or oncogene activation through a process known as cellular senescence. This cell-autonomous tumor-suppressive mechanism is also a major mechanism operative in organismal aging. To date, temporal aspects of senescence remain understudied.
Peter F. Doubleday +2 more
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Radiation-induced senescence: therapeutic opportunities
Radiation Oncology, 2023 The limitation of cancer radiotherapy does not derive from an inability to ablate tumor, but rather to do so without excessively damaging critical tissues and organs and adversely affecting patient’s quality of life.
Jae Ho Kim +2 more
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