Results 21 to 30 of about 50,933 (296)

Growth differentiation factor‐15 is associated with age‐related monocyte dysfunction

Aging Medicine, 2021
Objective Age‐associated decreases in immune functions are precipitated by a variety of mechanisms and affect nearly every immune cell subset. In myeloid cells, aging reduces numbers of phagocytes and impairs their functional abilities, including antigen
Brandt D. Pence, Johnathan R. Yarbro, Russell S. Emmons   +2 more
doaj   +1 more source

Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype [PDF]

Scientific Reports, 2021
Abstract Senescent cells are capable of expressing a myriad of inflammatory cytokines and this pro-inflammatory phenomenon is known as senescence-associated secretory phenotype (SASP). The contribution of this phenomenon in brain ischemia was scarce.
Torres Querol, Coral, Torres, Pascual, Vidal, Noemí, Portero-Otin, Manuel, Arque, Gloria, Purroy, Francisco   +5 more
openaire   +4 more sources

Altered regulation of mesenchymal cell senescence in adipose tissue promotes pathological changes associated with diabetic wound healing

Communications Biology, 2022
Type-2 diabetic adipose tissue impairs transient senescence during wound healing with expression of different components of the senescence-associated secretory phenotype (SASP), and this is associated with deteriorated wound healing.
Arisa Kita, Yuki Saito, Norihiro Miura, Maki Miyajima, Sena Yamamoto, Tsukasa Sato, Takatoshi Yotsuyanagi, Mineko Fujimiya, Takako S. Chikenji   +8 more
doaj   +1 more source

Bone marrow senescence and the microenvironment of hematological malignancies [PDF]

, 2020
Senescence is the irreversible arrest of cell proliferation that has now been shown to play an important role in both health and disease. With increasing age senescent cells accumulate throughout the body, including the bone marrow and this has been ...
Bowles, Kristian M., Hellmich, Charlotte, Moore, Jamie A., Rushworth, Stuart A.   +3 more
core   +1 more source

Overcoming the senescence‐associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer

Molecular Oncology, 2021
Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of suppressing tumour cell proliferation.
Cecilia R. Chambers, Shona Ritchie, Brooke A. Pereira, Paul Timpson   +3 more
doaj   +1 more source

MLL1 is essential for the senescence-associated secretory phenotype [PDF]

Genes & Development, 2016
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the senescence-associated secretory phenotype (SASP ...
Capell, Brian C., Drake, Adam M., Zhu, Jiajun, Shah, Parisha P., Dou, Zhixun, Dorsey, Jean, Simola, Daniel F., Donahue, Greg, Sammons, Morgan, Rai, Taranjit, Natale, Christopher, Ridky, Todd W., Adams, Peter D., Berger, Shelley L.   +13 more
openaire   +3 more sources

Suppression of p16 alleviates the senescence-associated secretory phenotype

Aging, 2021
Oncogene-induced senescence (OIS) is characterized by increased expression of the cell cycle inhibitor p16, leading to a hallmark cell cycle arrest. Suppression of p16 in this context drives proliferation, senescence bypass, and contributes to tumorigenesis.
Buj, Raquel, Leon, Kelly E., Anguelov, Marlyn A., Aird, Katherine M.   +3 more
openaire   +2 more sources

The Role of Senescence-Associated Secretory Phenotype in Bone Loss [PDF]

Frontiers in Cell and Developmental Biology, 2022
As the population of most nations have a large proportion of older individuals, there is an increase in the prevalence of osteoporosis. Consequently, scientists have focused their attention on the pathogenic mechanisms of osteoporosis. Owing to an increase in studies on cellular senescence in recent years, research has begun to focus on the function of
Runjiu Zhu, Runjiu Zhu, Haoyang Wan, Haoyang Wan, Hong Yang, Mingrui Song, Mingrui Song, Yu Chai, Yu Chai, Bin Yu, Bin Yu   +10 more
openaire   +3 more sources

NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype. [PDF]

Inflamm Res
Abstract Background Senescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory factors referred to as senescence-associated secretory phenotype (SASP), some of which are produced by the NLRP3 inflammasome.
Muela-Zarzuela I, Suarez-Rivero JM, Gallardo-Orihuela A, Wang C, Izawa K, de Gregorio-Procopio M, Couillin I, Ryffel B, Kitaura J, Sanz A, von Zglinicki T, Mbalaviele G, Cordero MD.   +12 more
europepmc   +3 more sources

Late Depression and Senescence-Associated Secretory Phenotype (SASP) [PDF]

Eur Psychiatry
IntroductionNeurobiological mechanisms of late depression include abnormal regulation and interaction of multiple biological processes, as well as abnormalities of brain structures and organs.Objectivesliterature analysisMethodsgeneral scientific methodResultsThe results of the study show that the SASP index as an integral indicator of changes in ...
Sidenkova A.
europepmc   +2 more sources