Results 11 to 20 of about 8,472,936 (269)
Measuring the Senescence-Associated Secretory Phenotype [PDF]
BiomedicinesCellular senescence is a fundamental hallmark of aging, contributing to tissue dysfunction and chronic disease through the senescence-associated secretory phenotype (SASP).
Konstantia Kantartzi +2 more
exaly +7 more sources
Recent advances in senescence-associated secretory phenotype and osteoporosis
HeliyonThe worldwide elderly population is on the rise, and aging is a major osteoporosis risk factor. Senescent cells accumulation can have a detrimental effect the body as we age.
Huifang Su +2 more
exaly +6 more sources
Cell senescence, the senescence-associated secretory phenotype, and cancers.
PLoS Biology, 2023 Cellular senescence is a cell fate caused by multiple stresses. A 2008 article in PLOS Biology reported a senescence-associated secretory phenotype that can promote inflammation and cancer, eventually enabling the development of senolytic drugs.
Larissa G P Langhi Prata +2 more
doaj +4 more sources
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype [PDF]
Frontiers in Cell and Developmental Biology, 2021 Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in response to various intrinsic and extrinsic stimuli, as well as developmental signals.
Parmjit Jat
exaly +5 more sources
HMGB2 holds the key to the senescence-associated secretory phenotype [PDF]
Journal of Cell Biology, 2016 The senescence-associated secretory phenotype (SASP) is a hallmark of senescence with an important physiological impact, but how it is established is unclear. In this issue, Aird et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201608026) describe how chromatin-bound HMGB2 fine tunes SASP expression by avoiding heterochromatin spreading.
Guerrero a, Gil, J
openaire +5 more sources
MLL1 is essential for the senescence-associated secretory phenotype [PDF]
Genes & Development, 2016 Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the senescence-associated secretory phenotype (SASP ...
Capell, Brian C. +13 more
openaire +5 more sources
Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype [PDF]
Journal of Proteome Research, 2020 Primary diploid cells exit the cell cycle in response to exogenous stress or oncogene activation through a process known as cellular senescence. This cell-autonomous tumor-suppressive mechanism is also a major mechanism operative in organismal aging. To date, temporal aspects of senescence remain understudied.
Peter F. Doubleday +2 more
core +6 more sources
Journal of Orthopaedic TranslationAs a permanent state of cell cycle arrest, cellular senescence has become an important factor in aging and age-related diseases. As a central regulator of physiology and pathology associated with cellular senescence, the senescence associated secretory ...
Yang Liu +3 more
doaj +2 more sources
Antioxidants, 2023 Inflammaging is a potential risk factor for cardiovascular diseases. It results in the development of thrombosis and atherosclerosis. The accumulation of senescent cells in vessels causes vascular inflammaging and contributes to plaque formation and ...
Huakang Zhou +6 more
doaj +2 more sources
Nicotinamide Improves Skin Photoaging in Mice by Delaying Cellular Senescence and Suppressing the Senescence-Associated Secretory Phenotype [PDF]
Current Issues in Molecular BiologyNicotinamide (NAM), a precursor of nicotinamide adenine dinucleotide (NAD+), and NAD+ are integral to a variety of cellular processes. NAM supplementation has been shown to have benefits for cellular senescence.
Xin-Yue Tang +8 more
doaj +2 more sources