Recent advances in senescence-associated secretory phenotype and osteoporosis [PDF]
HeliyonThe worldwide elderly population is on the rise, and aging is a major osteoporosis risk factor. Senescent cells accumulation can have a detrimental effect the body as we age.
Haonan Fan +9 more
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Measuring the Senescence-Associated Secretory Phenotype [PDF]
BiomedicinesCellular senescence is a fundamental hallmark of aging, contributing to tissue dysfunction and chronic disease through the senescence-associated secretory phenotype (SASP).
Achilleas Karras +5 more
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Cell senescence, the senescence-associated secretory phenotype, and cancers.
PLoS Biology, 2023 Cellular senescence is a cell fate caused by multiple stresses. A 2008 article in PLOS Biology reported a senescence-associated secretory phenotype that can promote inflammation and cancer, eventually enabling the development of senolytic drugs.
Larissa G P Langhi Prata +2 more
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Basal Cells Contribute to Pulmonary Fibrosis via SP1‐Mediated Senescence‐Associated Secretory Phenotype [PDF]
The Clinical Respiratory JournalIdiopathic pulmonary fibrosis is a progressive interstitial lung disease with limited treatment options and poor prognosis. Increasing evidence suggests that airway epithelial remodeling contributes to disease pathogenesis, yet the role of basal cells ...
Xiaoyan Wang +5 more
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Altered Senescence-Associated Secretory Phenotype of Human Osteoblasts from Patients with Osteoporosis Enhances Endothelial Cell Migration and Proliferation In Vitro [PDF]
BiologyOsteoporosis (OP) is a highly prevalent age-associated inflammatory bone disease that remains underdiagnosed and undertreated despite its substantial global burden.
Lisa Oezel +9 more
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Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
Frontiers in Cell and Developmental Biology, 2021 Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in response to various intrinsic and extrinsic stimuli, as well as developmental signals.
Ruchi Kumari, Parmjit Jat
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Journal of Extracellular Vesicles, 2021 A hallmark of senescence is the acquisition of an enhanced secretome comprising inflammatory mediators and tissue remodelling agents – the senescence‐associated secretory phenotype (SASP).
Ryan Wallis +6 more
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Journal of Functional Biomaterials, 2022 Senescent cells accumulate in aged organisms and promote the progression of age-related diseases including cataracts. Therefore, we aimed to study the therapeutic effects of senescence-targeting drugs on cataracts.
Yinhao Wang +5 more
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MLL1 is essential for the senescence-associated secretory phenotype [PDF]
Genes & Development, 2016 Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the senescence-associated secretory phenotype (SASP ...
Capell, Brian C. +13 more
openaire +3 more sources
Growth differentiation factor‐15 is associated with age‐related monocyte dysfunction
Aging Medicine, 2021 Objective Age‐associated decreases in immune functions are precipitated by a variety of mechanisms and affect nearly every immune cell subset. In myeloid cells, aging reduces numbers of phagocytes and impairs their functional abilities, including antigen
Brandt D. Pence +2 more
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