Results 11 to 20 of about 8,942,313 (272)

HMGB2 holds the key to the senescence-associated secretory phenotype [PDF]

Journal of Cell Biology, 2016
The senescence-associated secretory phenotype (SASP) is a hallmark of senescence with an important physiological impact, but how it is established is unclear. In this issue, Aird et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201608026) describe how chromatin-bound HMGB2 fine tunes SASP expression by avoiding heterochromatin spreading.
Guerrero a, Gil, J
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Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype [PDF]

Frontiers in Cell and Developmental Biology, 2021
Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in response to various intrinsic and extrinsic stimuli, as well as developmental signals.
Ruchi Kumari, Parmjit Jat
doaj   +3 more sources

Colchicine Protects against Ethanol-Induced Senescence and Senescence-Associated Secretory Phenotype in Endothelial Cells

Antioxidants, 2023
Inflammaging is a potential risk factor for cardiovascular diseases. It results in the development of thrombosis and atherosclerosis. The accumulation of senescent cells in vessels causes vascular inflammaging and contributes to plaque formation and ...
Huakang Zhou, Dilaware Khan, Norbert Gerdes, Carsten Hagenbeck, Majeed Rana, Jan Frederick Cornelius, Sajjad Muhammad   +6 more
doaj   +2 more sources

MLL1 is essential for the senescence-associated secretory phenotype [PDF]

Genes & Development, 2016
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation. This inflammatory response prominently includes an array of cytokines known as the senescence-associated secretory phenotype (SASP ...
Capell, Brian C., Drake, Adam M., Zhu, Jiajun, Shah, Parisha P., Dou, Zhixun, Dorsey, Jean, Simola, Daniel F., Donahue, Greg, Sammons, Morgan, Rai, Taranjit, Natale, Christopher, Ridky, Todd W., Adams, Peter D., Berger, Shelley L.   +13 more
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Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype [PDF]

Journal of Proteome Research, 2020
Primary diploid cells exit the cell cycle in response to exogenous stress or oncogene activation through a process known as cellular senescence. This cell-autonomous tumor-suppressive mechanism is also a major mechanism operative in organismal aging. To date, temporal aspects of senescence remain understudied.
Peter F. Doubleday, Luca Fornelli, Neil L. Kelleher   +2 more
core   +6 more sources

Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironment

Journal of Orthopaedic Translation
As a permanent state of cell cycle arrest, cellular senescence has become an important factor in aging and age-related diseases. As a central regulator of physiology and pathology associated with cellular senescence, the senescence associated secretory ...
Yang Liu, Yiming Dou, Xun Sun, Qiang Yang   +3 more
doaj   +2 more sources

NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype [PDF]

Inflammation Research
Abstract Background Senescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory factors referred to as senescence-associated secretory phenotype (SASP), some of which are produced by the NLRP3 inflammasome.
Muela-Zarzuela, Inés, Suarez-Rivero, Juan Miguel, Gallardo-Orihuela, Andrea, Wang, Chun, Izawa, Kumi, de Gregorio-Procopio, Marta, Couillin, Isabelle, Ryffel, Bernhard, Kitaura, Jiro, Sanz, Alberto, von Zglinicki, Thomas, Mbalaviele, Gabriel, Cordero, Mario D.   +12 more
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Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy

Frontiers in Oncology, 2018
In addition to promoting various forms of cell death, most conventional anti-tumor therapies also promote senescence. There is now extensive evidence that therapy-induced senescence (TIS) might be transient, raising the concern that TIS could represent ...
Tareq Saleh, Tareq Saleh, Liliya Tyutynuk-Massey, Liliya Tyutynuk-Massey, Emmanuel K. Cudjoe, Michael O. Idowu, Joseph W. Landry, Joseph W. Landry, David A. Gewirtz, David A. Gewirtz   +9 more
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Senescence And The Senescence Associated Secretory Phenotype In Salivary Hypofunction [PDF]

Cellular senescence, a triggered permanent cycle arrest, occurs with aging and is a component of many aging-related diseases. Triggers for senescence may include pathways involving DNA damage, telomere dysfunction, release of reactive oxygen species, and
Jean-Baptiste, Quetsia
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Targeting the senescence-associated secretory phenotype in cancer therapy

, 2023
The current main strategy in the treatment of cancer is to target rapidly dividing cells, which induces DNA damage and promotes senescence in both cancerous and non-malignant cells alike.
Niamh Kerslake (16845207)
core   +3 more sources