Results 31 to 40 of about 8,472,936 (269)
Senescent cells and macrophages: key players for regeneration? [PDF]
Open Biology, 2020 Over the last decade, our understanding of the physiological role of senescent cells has drastically evolved, from merely indicators of cellular stress and ageing to having a central role in regeneration and repair.
Sonia S. Elder, Elaine Emmerson
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Suppression of p16 alleviates the senescence-associated secretory phenotype
Aging, 2021 Oncogene-induced senescence (OIS) is characterized by increased expression of the cell cycle inhibitor p16, leading to a hallmark cell cycle arrest. Suppression of p16 in this context drives proliferation, senescence bypass, and contributes to tumorigenesis.
Buj, Raquel +3 more
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Communications Biology, 2022 Type-2 diabetic adipose tissue impairs transient senescence during wound healing with expression of different components of the senescence-associated secretory phenotype (SASP), and this is associated with deteriorated wound healing.
Arisa Kita +8 more
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Molecular Oncology, 2021 Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of suppressing tumour cell proliferation.
Cecilia R. Chambers +3 more
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Radiation-induced senescence: therapeutic opportunities
Radiation Oncology, 2023 The limitation of cancer radiotherapy does not derive from an inability to ablate tumor, but rather to do so without excessively damaging critical tissues and organs and adversely affecting patient’s quality of life.
Jae Ho Kim +2 more
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Senescence: Definition, mechanisms of occurence and detection in tissues [PDF]
Medicinski PodmladakA cellular senescence represents a state, which is defined as a stable blockage of the cellular cycle in the G1 phase, as an answer to multiple triggers and their qualitative and quantitative characteristics. Alongside the blockage of the cellular cycle,
Mijajlović Vladimir +2 more
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The Paradoxical Role of Cellular Senescence in Cancer
Frontiers in Cell and Developmental Biology, 2021 Cellular senescence occurs in proliferating cells as a consequence of various triggers including telomere shortening, DNA damage, and inappropriate expression of oncogenes.
Jing Yang +7 more
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Frontiers in Endocrinology, 2022 Cellular senescence is a stress or damage response by which a cell adopts of state of essentially permanent proliferative arrest, coupled to the secretion of a number of biologically active molecules. This senescence-associated secretory phenotype (SASP) underlies many of the degenerative and regenerative aspects of cellular senescence - including ...
Chisaka Kuehnemann +8 more
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G3BP1 controls the senescence-associated secretome and its impact on cancer progression
Nature Communications, 2020 The mechanisms that control the deleterious behaviour of senescent cells is unclear. Here, the authors show that G3BP1 is required for the induction of the senescence-associated secretory phenotype (SASP), without affecting senescence, and that SASP ...
Amr Omer +6 more
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Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α-Dependent Senescence-Associated Secretory Phenotype. [PDF]
, 2015 OBJECTIVE: Vascular smooth muscle cells (VSMCs) that become senescent are both present within atherosclerotic plaques and thought to be important to the disease process.
Sarah E. Gardner +3 more
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