Results 31 to 40 of about 50,933 (296)
NF90 coordinately represses the senescence-associated secretory phenotype
Aging, 2012 A hallmark trait of cellular senescence is the acquisition of a senescence-associated secretory phenotype (SASP). SASP factors include cytokines and their receptors (IL-6, IL-8, osteoprotegerin, GM-CSF), chemokines and their ligands (MCP-1, HCC4), and oncogenes (Gro1 and Gro2), many of them encoded by mRNAs whose stability and translation are tightly ...
Kumiko, Tominaga-Yamanaka +5 more
openaire +2 more sources
Engineering mammalian cells to seek senescence-associated secretory phenotypes [PDF]
Journal of Cell Science, 2017 ABSTRACT Since the removal of senescent cells in model organisms has been linked to rejuvenation and increased lifespan, senotherapies have emerged to target senescent cells for death. In particular, interleukin-6 (IL6) is a prominent senescence-associated secretory phenotype (SASP) and, thus, seeking IL6 could potentially localize ...
Anam Qudrat, Janice Wong, Kevin Truong
openaire +2 more sources
Redox control of senescence and age-related disease
Redox Biology, 2017 The signaling networks that drive the aging process, associated functional deterioration, and pathologies has captured the scientific community's attention for decades.
Akshaya Chandrasekaran +2 more
doaj +1 more source
G3BP1 controls the senescence-associated secretome and its impact on cancer progression
Nature Communications, 2020 The mechanisms that control the deleterious behaviour of senescent cells is unclear. Here, the authors show that G3BP1 is required for the induction of the senescence-associated secretory phenotype (SASP), without affecting senescence, and that SASP ...
Amr Omer +6 more
doaj +1 more source
Antioxidants, 2023 Inflammaging is a potential risk factor for cardiovascular diseases. It results in the development of thrombosis and atherosclerosis. The accumulation of senescent cells in vessels causes vascular inflammaging and contributes to plaque formation and ...
Huakang Zhou +6 more
doaj +1 more source
RUNX-mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins [PDF]
, 2018 RUNX gene over-expression inhibits growth of primary cells but transforms cells with tumor suppressor defects, consistent with reported associations with tumor progression.
Anderson, Gail +10 more
core +1 more source
Radiation-induced senescence: therapeutic opportunities
Radiation Oncology, 2023 The limitation of cancer radiotherapy does not derive from an inability to ablate tumor, but rather to do so without excessively damaging critical tissues and organs and adversely affecting patient’s quality of life.
Jae Ho Kim +2 more
doaj +1 more source
The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology [PDF]
, 2019 Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune response to cancer. Thus, induction of their activity is the ultimate aim of all immunotherapies.
Dey, Mahua +4 more
core +1 more source
TORCing to secretory senescence [PDF]
, 2015 Cellular senescence is often accompanied by the production of secreted proteins that mediate the diverse effects of senescence on the tissue microenvironment. The mammalian target of rapamycin (mTOR), a master regulator of protein synthesis, is now shown
Narita, Masashi, Tomimatsu, Kosuke
core +1 more source
Effect of menopausal hormone therapy on proteins associated with senescence and inflammation
Physiological Reports, 2020 Background Estrogen may inhibit cell senescence that contributes to age‐related disorders. This study determined the effects of menopausal hormone treatments on circulating levels of markers of cell senescence.
Laura Faubion +7 more
doaj +1 more source