Results 1 to 10 of about 8,908 (223)
Mitochondrial bioenergetics-SASP crosstalk determines senolytic efficacy in therapy-induced senescence [PDF]
Cell Death DiscoveryMitochondria integrate senescence and apoptotic fates, yet it is unclear whether their ability to oxidize different fuels for energy production influences their vulnerability to senolytics in therapy-induced senescence (TIS). Using MitoPlates™ technology,
Àngela Llop-Hernández +5 more
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Targeting senescent microglia in progressive multiple sclerosis: a geroscience-informed approach [PDF]
Frontiers in ImmunologyMultiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disorder of the central nervous system (CNS). Age is the strongest predictor of disease phenotype, with the majority of older adults transitioning to a progressive form marked by ...
Jeffrey Atkinson +9 more
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Improvement of the ability of bone repair by reducing the aging degree of mesenchymal stem cell population by Senolytic drugs [PDF]
E3S Web of Conferences, 2021 In order to study the effects of Senolytic drugs dasatinib and quercetin on the aging of mesenchymal stem cells (MSCs) and explore the application of young MSCs in repairing bone defects, the cultured and identified MSCs were treated with dasatinib and ...
Liu Jia, He Lian, Zhou Peng, Chen Danna
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344 The Potential Benefits of Using Senolytics in Colorectal Cancer Treatment
Journal of Clinical and Translational Science, 2023 OBJECTIVES/GOALS: Anti-cancer therapies, such as chemotherapy, can induce senescence. Senescent cells may produce factors that can promote tumor progression.
Valerie Gallegos +6 more
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Redox Biology, 2020 Cellular senescence may contribute to aging and age-related diseases and senolytic drugs that selectively kill senescent cells may delay aging and promote healthspan.
Anna Lewinska +8 more
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Evaluating the neuroprotective impact of senolytic drugs on human vision
Scientific Reports, 2020 Glaucoma, a chronic neurodegenerative disease of retinal ganglion cells (RGCs), is a leading cause of irreversible blindness worldwide. Its management currently focuses on lowering intraocular pressure to slow disease progression.
Nevin W. El-Nimri +6 more
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Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration
Frontiers in Bioengineering and Biotechnology, 2022 Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar spondylosis. Over the past few years, the relevance between cellular senescence and IVDD has been widely studied, and the senescence-associated secretory phenotype (SASP ...
Yuhao Wu +16 more
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Nintedanib induces senolytic effect via STAT3 inhibition
Cell Death and Disease, 2022 Selective removal of senescent cells, or senolytic therapy, has been proposed to be a potent strategy for overcoming age-related diseases and even for reversing aging.
Hyun-Ji Cho +8 more
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Frontiers in Cardiovascular Medicine, 2021 Background: Following an acute coronary syndrome, patients display an elevated inflammatory profile, promoted in part by cellular senescence. For patients requiring a coronary artery bypass (CABG) surgery, exposure to the surgical intervention and ...
Olina Dagher +12 more
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Senotherapeutics in Cancer and HIV
Cells, 2022 Cellular senescence is a stress-response mechanism that contributes to homeostasis maintenance, playing a beneficial role during embryogenesis and in normal adult organisms.
Laura Sánchez-Díaz +3 more
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