Results 101 to 110 of about 8,908 (223)

Spontaneous DNA damage to the nuclear genome promotes senescence,redox imbalance and aging [PDF]

, 2018
Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a genetic approach to determine if spontaneous nuclear DNA damage is sufficient to initiate ...
Bell-Temin, Harris, Burd, Christin E., Cantu-Medellin, Nadiezhda, Cifuentes-Pagano, Eugenia, Czerwińska, Jolanta, Feldman, Chelsea H., Frantz, Marie-Céline, Fuhrmann-Stroissnigg, Heike, Gregg, Siobhán Q., Gurkar, Aditi U., Harris, Jamie B., Johnson, Caroline H., Kelley, Eric E., LaRusso, Nicholas F., Li, Xuesen, M. St. Croix, Claudette, Maniar, Salony, McGowan, Sara J., Nasto, Luigi A., Niedernhofer, Laura J., Opresko, Patricia L., Pagano, Patrick J., Pope-Varsalona, Hannah, Rigatti, Lora H., Robbins, Paul D., Robinson, Andria R., Robinson, Renã A.S., Ross, Mark A., Rozgaja, Tania A., Siuzdak, Gary, Skoda, Erin M., Stolz, Donna B., Tilstra, Jeremy S., Trussoni, Christy E., Tudek, Barbara, Vo, Nam V., Wang, Jin, Wang, Yinsheng, Watkins, Simon C., Wipf, Peter, Yates, Nathan A., Yousefzadeh, Matt J.   +41 more
core   +3 more sources

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

Sex, senescence, senolytics, and cognition

Frontiers in Aging Neuroscience
This review focuses on sexual dimorphism in cellular senescence and senolytic treatment in relation to brain health and age-related cognitive decline. The stressors of aging, DNA damage, inflammation, and oxidative stress induce cell senescence, a hallmark of aging.
Thomas C. Foster, Thomas C. Foster, Ashok Kumar   +2 more
openaire   +3 more sources

Mitochondrial Homeostasis and Cellular Senescence [PDF]

, 2019
Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and ...
Chronopoulos, Efstathios, Evangelou, Konstantinos, Fildisis, Georgios, Gorgoulis, Vassilis G., Havaki, Sophia, Kouloukoussa, Mirsini, Panagiotidis, Mihalis, Passias, Panagiotis-Georgios, Vasileiou, Panagiotis V.S., Vlasis, Konstantinos   +9 more
core   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity. [PDF]

, 2020
Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse disease models, including cancer ...
Bernardos, Andrea, Blandez, Juan F, Doherty, Gary J, Fruk, Ljiljana, González-Gualda, Estela, González-López, Cristina, Lozano-Torres, Beatriz, Lérida-Viso, Araceli, Macias, David, Martins, Carla P, Martínez-Máñez, Ramón, Mirón-Barroso, Sofía, Muñoz-Espín, Daniel, Ou, Hui-Ling, Pàez-Ribes, Marta, Rovira, Miguel, Sancenón, Félix, Serrano, Manuel, Wilson, Joseph R, Zhang, Zhenguang   +19 more
core   +2 more sources

Treating age‐related loss of muscle mass and function: Where should we be focusing?

The Journal of Physiology, EarlyView.
Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham, Christopher S. Fry, Avnika Ashok Ruparelia, Shyuan T. Ngo, Séverine Lamon   +4 more
wiley   +1 more source

Senolytic treatment alleviates doxorubicin‐induced chemobrain

Aging Cell
AbstractDoxorubicin (Dox), a widely used treatment for cancer, can result in chemotherapy‐induced cognitive impairments (chemobrain). Chemobrain is associated with inflammation and oxidative stress similar to aging. As such, Dox treatment has also been used as a model of aging.
Vivekananda Budamagunta, Ashok Kumar, Asha Rani, Sahana Manohar Sindhu, Yang Yang, Daohong Zhou, Thomas C. Foster   +6 more
openaire   +2 more sources

Does Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Skeletal muscle in individuals with cerebral palsy (CP) may undergo accelerated aging through mechanisms shared with age‐related sarcopenia. Representative overlapping molecular and cellular features include, for example, neuromuscular alterations, impaired satellite cell function and niche composition, chronic inflammation, metabolic deficits, reduced
Oscar Horwath, Sebastian Edman, Sudarshan Dayanidhi, Davis Englund, Mark D. Peterson, Ferdinand von Walden   +5 more
wiley   +1 more source

Self‐Immolative Systems in Diagnostic and Therapeutic Applications

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Self‐Immolative Systems enable the precise, residue‐free release of active molecules, drugs, probes, or sensors, via cyclization or elimination, triggered by specific stimuli. Their versatility drives advances in drug delivery, diagnostics, nanotechnology, materials chemistry, and biosensing, offering chemists control over molecular activation and ...
Windbedema Prisca Ouédraogo, Thomas Cailly, Valérie Collot   +2 more
wiley   +1 more source