Results 121 to 130 of about 8,908 (223)

Rejuvenation of brain, liver and muscle by simultaneous pharmacological modulation of two signaling determinants, that change in opposite directions with age. [PDF]

, 2019
We hypothesize that altered intensities of a few morphogenic pathways account for most/all the phenotypes of aging. Investigating this has revealed a novel approach to rejuvenate multiple mammalian tissues by defined pharmacology.
Chen, Chia-Chien, Conboy, Irina M, Conboy, Michael J, Etienne, Jessy, Gathwala, Ranveer, Kato, Cameron, Liu, Chao, Liu, Yutong, Mehdipour, Melod, Rehman, Maryam, Zuo, Yi   +10 more
core  

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Senolytic treatment for low back pain

Science Advances
Senescent cells (SnCs) accumulate because of aging and external cellular stress throughout the body. They adopt a senescence-associated secretory phenotype (SASP) and release inflammatory and degenerative factors that actively contribute to age-related diseases, such as low back pain (LBP). The senolytics, o
Mannarino, Matthew, Cherif, Hosni, Ghazizadeh, Saber, Martinez, Oliver Wu, Sheng, Kai, Cousineau, Elsa, Lee, Seunghwan, Millecamps, Magali, Gao, Chan, Gilbert, Alice, Peirs, Cedric, Naeini, Reza Sharif, Ouellet, Jean, S. Stone, Laura, Haglund, Lisbet   +14 more
openaire   +3 more sources

Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proliferation, while the senescence‐associated secretory phenotype (SASP) secretion enhances antitumor immunity by activating cytotoxic T cells.
Huajie Mao, Wanning Liu, Yuanyuan Su, Yuxuan Ma, Xiaodi Zhao, Yuanyuan Lu   +5 more
wiley   +1 more source

Defining melanoma combination therapies that provide senolytic sensitivity in human melanoma cells

Frontiers in Cell and Developmental Biology
Malignant Melanoma that resists immunotherapy remains the deadliest form of skin cancer owing to poor clinically lasting responses. Alternative like genotoxic or targeted chemotherapy trigger various cancer cell fates after treatment including cell death
Daméhan Tchelougou, Nicolas Malaquin, Guillaume B. Cardin, Jordan Desmul, Simon Turcotte, Simon Turcotte, Francis Rodier, Francis Rodier   +7 more
doaj   +1 more source

Senescent Mesenchymal Stromal Cells Differentially Alter Adipogenesis in Adipose Tissue, Skeletal Muscle, and Bone Marrow

Obesity, Volume 34, Issue 3, Page 652-661, March 2026.
ABSTRACT Objective Aging alters mesenchymal stromal cell (MSC) function, leading to dysregulated adipogenesis across tissues through biased lineage commitment. Fat redistribution from adipose depots to skeletal muscle and bone marrow is common in aging, but the underlying mechanisms remain unclear.
Xu Zhang, Madison L. Doolittle, Ting Fan, Utkarsh Tripathi, Yan Er Ng, Xinyi Jiang, João F. Passos, Diana Jurk, David G. Monroe, Tamara Tchkonia, James L. Kirkland, Paul D. Robbins, Sundeep Khosla, Nathan K. LeBrasseur   +13 more
wiley   +1 more source

Ganoderma lucidum Extract Modulates Gene Expression Profiles Associated with Antioxidant Defense, Cytoprotection, and Senescence in Human Dermal Fibroblasts: Investigation of Quantitative Gene Expression by qPCR

Current Issues in Molecular Biology
Cellular senescence plays a crucial role in skin aging, with senescent dermal fibroblasts contributing to reduced skin elasticity and increased inflammation.
Harald Kühnel, Markus Seiler, Barbara Feldhofer, Atefeh Ebrahimian, Michael Maurer   +4 more
doaj   +1 more source

Failure of senolytic treatment to prevent cognitive decline in a female rodent model of aging

Frontiers in Aging Neuroscience
There are sex differences in vulnerability and resilience to the stressors of aging and subsequent age-related cognitive decline. Cellular senescence occurs as a response to damaging or stress-inducing stimuli.
Asha Rani, Linda Bean, Vivekananda Budamagunta, Vivekananda Budamagunta, Vivekananda Budamagunta, Ashok Kumar, Thomas C. Foster, Thomas C. Foster   +7 more
doaj   +1 more source

Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog [PDF]

The emerging field of senolytics is centered on eliminating senescent cells to block their contribution to the progression of age-related diseases, including cancer, and to facilitate healthy aging.
Boukos, Nikos, Evangelou, Konstantinos, Georgiou, Maria, Gorgoulis, Vassilis G., Havaki, Sophia, Kambas, Konstantinos, Kotopoulos, Nicholas, Kotsinas, Athanassios, Lagopati, Nefeli, Lougiakis, Nikolaos, Magkouta, Sophia, Marakos, Panagiotis, Palaiologou, Anastasia, Papaspyropoulos, Angelos, Petty, Russell, Pippa, Natassa, Pispas, Stergios, Pouli, Nicole, Sampaziotis, Fotios, Tamvakopoulos, Constantin, Thanos, Dimitris, Thanos, Dimitris Foivos, Veroutis, Dimitris   +22 more
core   +2 more sources

Host Aging Induces a Senescent‐Like Phenotype in Neutrophils and Altered Transcriptional Responses to Streptococcus pneumoniae

Aging Cell, Volume 25, Issue 3, March 2026.
Aging is associated with a senescent‐like phenotype in neutrophils that emerges in bone marrow cells; however, many facets of this phenotype are only fully acquired upon entry into peripheral tissues. This neutrophil senescent‐like phenotype is in part driven by TNFα and impairs resistance of aged hosts to S. pneumoniae. Created in BioRender. Boughanem
Michael C. Battaglia, Manmeet Bhalla, Brandon Marzullo, Anagha Betadpur, Alexsandra P. Lenhard, Rania Hassan Mohamed, Murat C. Kalem, Lauren R. Heinzinger, Pathricia A. Leus, Samuel Labarron, Lee Ann Garrett‐Sinha, Joan Mecsas, Anna Blumental‐Perry, Elsa N. Bou Ghanem   +13 more
wiley   +1 more source