Results 11 to 20 of about 8,908 (223)

A pipeline for senolytics

The Journal of Clinical Investigation
There is intense interest in identifying compounds that selectively kill senescent cells, termed senolytics, for ameliorating age-related comorbidities.
Sundeep Khosla
doaj   +3 more sources

Cardiac glycosides are broad-spectrum senolytics [PDF]

Nature Metabolism, 2019
Senescence is a cellular stress response that results in the stable arrest of old, damaged or pre-neoplastic cells. Oncogene-induced senescence is tumour suppressive but can also exacerbate tumorigenesis through the secretion of proinflammatory factors ...
Guerrero, A, Herranz, N, Sun, B, Wagner, V, Gallage, S, Guiho, R, Wolter, K, Pombo, J, Irvine, EE, Innes, AJ, Birch, J, Glegola, J, Manshaei, S, Heide, D, Dharmalingam, G, Harbig, J, Olona, A, Behmoaras, J, Dauch, D, Uren, AG, Zender, L, Vernia, S, Martínez-Barbera, JP, Heikenwalder, M, Withers, DJ, Gil, J   +25 more
core   +7 more sources

Development and Application of a Senolytic Predictor for Discovery of Novel Senolytic Compounds and Herbs

Molecules
The accumulation of senescent cells is a major contributor to aging and various age-related diseases, making developing senolytic compounds that are capable of clearing these cells an important area of research. However, progress has been hampered by the
Jinjun Li, Kai Zhao, Guotai Yang, Haohao Lv, Renxin Zhang, Shuhan Li, Zhiyuan Chen, Min Xu, Naixue Yang, Shaoxing Dai   +9 more
doaj   +2 more sources

Identification and characterization of Cardiac Glycosides as senolytic compounds [PDF]

Nature Communications, 2019
Senolytic compounds have the ability to eliminate senescent cells from tissues and have been shown to be beneficial in various animal models of age-related diseases.
Francisco Triana-Martínez, Pilar Picallos-Rabina, Sabela Da Silva-Álvarez, Federico Pietrocola, Susana Llanos, Verónica Rodilla, Enrica Soprano, Pablo Pedrosa, Alba Ferreirós, Marta Barradas, Fernanda Hernández-González, Marta Lalinde, Neus Prats, Cristina Bernadó, Patricia González, María Gómez, Maria P. Ikonomopoulou, Pablo J. Fernández-Marcos, Tomás García-Caballero, Pablo del Pino, Joaquín Arribas, Anxo Vidal, Miguel González-Barcia, Manuel Serrano, María I. Loza, Eduardo Domínguez, Manuel Collado   +26 more
doaj   +3 more sources

DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment. [PDF]

Aging Cell
We found very little overlap between CpGs that were correlated with in vitro senescence, chronological age, and mortality. While we were able to train epigenetic clocks with CpGs that accelerated with cellular senescence, these clocks did not decelerate with Senolytic treatment. ABSTRACT Epigenetic clocks are commonly used aging biomarkers based on DNA
Kasamoto J, González J, Markov Y, Sehgal R, Lee E, Dwaraka VB, Smith R, Higgins-Chen AT.   +7 more
europepmc   +2 more sources

Tacrolimus Induced Hypertension and Vascular Remodeling Includes Mechanisms of Cellular Senescence-The Protective Effect of Valsartan. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Calcineurin inhibitors (CNI) such as tacrolimus (Tac) are the first‐line treatment to prevent transplant rejection. However, CNI have adverse effects on blood vessels and renal function, which may be linked to cellular senescence. Valsartan, a common angiotensin II type 1 receptor (AT1R) blocker, exhibits anti‐senescence properties.
Fei L, Wang X, Kong L, Cui T, Khedkar PH, Xiang Y, Zhao D, Fang J, Liang Y, Zhang Y, Xu N, Qiu X, Zhao L, Zhang G, Lei Y, Tang C, Ma K, Lu L, Wei J, Lai EY, Persson PB, Patzak A, Zheng Z, Jiang S.   +23 more
europepmc   +2 more sources

Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. [PDF]

, 2020
The accumulation of senescent cells (SnCs) is a causal factor of various age-related diseases as well as some of the side effects of chemotherapy. Pharmacological elimination of SnCs (senolysis) has the potential to be developed into novel therapeutic ...
Budamagunta, Vivekananda, Campisi, Judith, He, Yonghan, Li, Wen, Lv, Dongwen, Ortiz, Yuma T, Zhang, Xin, Zhang, Xuan, Zheng, Guangrong, Zhou, Daohong   +9 more
core   +1 more source

COVID-19 and chronological aging : senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? [PDF]

, 2020
COVID-19, also known as SARS-CoV-2, is a new emerging zoonotic corona virus of the SARS (Severe Acute Respiratory Syndrome) and the MERS (Middle East Respiratory Syndrome) family.
Auwerx, Blagosklonny, Blagosklonny, Blagosklonny, Colasurdo, Colson, Diaz-Quijano, Du, Erusalimsky, Gerontol, Gorospe, Hoffmann, Häkkinen, Jang, Li, Lisanti, Lisanti, Lu, Masternak, Munster, Musso, Nowakowski, Porter, Subbarao, Subbarao, Tanga, Tremblay, Wilce, Yaron, Yusof, Zhang   +30 more
core   +2 more sources

Cardiac Glycosides as Senolytic Compounds [PDF]

Trends in Molecular Medicine, 2020
The identification of senolytics, compounds that eliminate senescent cells, is presently a key priority given their therapeutic promise in cancer and aging-associated diseases. Two recent papers by Triana-Martínez et al. and Guerrero et al. report the senolytic activity of cardiac glycosides (CGs) and their efficacy in these pathophysiological contexts.
Martin, Nadine, Soriani, Olivier, Bernard, David   +2 more
openaire   +2 more sources

The emerging role of cellular senescence in renal diseases [PDF]

, 2020
Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco, Chen, Rong, Francis, Heather, Glaser, Shannon, Li, Siwen, Li, Xuesen, Meng, Fanyin, Wan, Ying, Wu, Nan, Zhang, Chunmei, Zhou, Bingru, Zhou, Tianhao, Zou, Ping   +12 more
core   +1 more source