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Strategies for senolytic drug discovery
Aging Cell, 2023 AbstractSenolytics are a category of drugs that reduce the impact of cellular senescence, an effect associated with a range of chronic and age‐related diseases. Since the discovery of the first senolytics in 2015, the number of known senolytic agents has grown dramatically.
Helen Power +3 more
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Galactose‐modified duocarmycin prodrugs as senolytics [PDF]
Aging Cell, 2019 Abstract Senescence is a stable growth arrest that impairs the replication of damaged, old or preneoplastic cells, therefore contributing to tissue homeostasis. Senescent cells accumulate during ageing and are associated with cancer, fibrosis and many age‐related pathologies.
Guerrero, Ana +7 more
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Molecular Oncology, 2020 Tumor cells undergo senescence in response to both conventional and targeted cancer therapies. The induction of senescence in response to cancer therapy can contribute to unfavorable patient outcomes, potentially including disease relapse.
Tareq Saleh +10 more
doaj +1 more source
Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells. [PDF]
PLoS ONE, 2018 Previously, quercetin has been reported to be a senolytic, a drug that selectively removes senescent cells, in HUVECs. However, we found neither quercetin nor Q3G was effective as a senolytic for adult human endothelial cells.
HyunTae V Hwang +4 more
doaj +1 more source
Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development
Frontiers in Cell and Developmental Biology, 2022 Cellular senescence is a process that leads to a state of irreversible cell growth arrest induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate with age and have been implicated in various age-related diseases in ...
Li Hu +12 more
doaj +1 more source
Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts [PDF]
, 2018 Here, we employed a “senolytic” assay system as a screening tool, with the goal of identifying and repurposing FDA-approved antibiotics, for the targeting of the senescent cell population. Briefly, we used two established human fibroblast cell lines (MRC-
Ayusawa +28 more
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Cell & Bioscience, 2020 Background The benefit of inducing cellular senescence as a tumor suppressive strategy remains questionable due to the senescence-associated secretory phenotype.
Thanakorn Pungsrinont +6 more
doaj +1 more source
Lipotoxicity, aging, and muscle contractility: does fiber type matter? [PDF]
, 2019 Sarcopenia is a universal characteristic of the aging process and is often accompanied by increases in whole-body adiposity. These changes in body composition have important clinical implications, given that loss of muscle and gain of fat mass are both ...
Carter, Christy S. +2 more
core +1 more source
Impact of sitagliptin on endometrial mesenchymal stem-like progenitor cells : a randomised, double-blind placebo-controlled feasibility trial [PDF]
, 2020 Background: Recurrent pregnancy loss (RPL) is associated with the loss of endometrial mesenchymal stem-like progenitor cells (eMSC). DPP4 inhibitors may increase homing and engraftment of bone marrow-derived cells to sites of tissue injury.
Brighton, Paul (Paul J.) +13 more
core +1 more source
Discovery of senolytics using machine learning
Nature Communications, 2023 AbstractCellular senescence is a stress response involved in ageing and diverse disease processes including cancer, type-2 diabetes, osteoarthritis and viral infection. Despite growing interest in targeted elimination of senescent cells, only few senolytics are known due to the lack of well-characterised molecular targets. Here, we report the discovery
Vanessa Smer-Barreto +10 more
openaire +6 more sources