A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers
Disease Models & Mechanisms, 2022 To evaluate senescence mechanisms, including senescence-associated secretory phenotype (SASP), in the motor neuron disease model hSOD1-G93A, we quantified the expression of p16 and p21 and senescence-associated β-galactosidase (SA-β-gal) in nervous ...
Pascual Torres +10 more
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Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension. [PDF]
, 2020 Experimental ocular hypertension induces senescence of retinal ganglion cells (RGCs) that mimics events occurring in human glaucoma. Senescence-related chromatin remodeling leads to profound transcriptional changes including the upregulation of a subset ...
Jabari, Mary +7 more
core
Ethical perspectives on advances in biogerontology [PDF]
, 2019 Worldwide populations are aging with economic development as a result of public health initiatives and advances in therapeutic discoveries. Since 1850, life expectancy has advanced by 1 year for every four.
Archard, David +8 more
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A proteomic atlas of senescence-associated secretomes for aging biomarker development. [PDF]
, 2020 The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer.
Basisty, Nathan +11 more
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Nature Biotechnology, 2020 Despite early failures in the clinic, the idea of anti-aging therapies that purge the body of dying cells is gaining traction with a raft of startups now focused on senescence.
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Doxycycline, Azithromycin and vitamin C (DAV) : a potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs) [PDF]
, 2019 Here, we devised a new strategy for eradicating cancer stem cells (CSCs), via a "synthetic-metabolic" approach, involving two FDA-approved antibiotics and a dietary vitamin supplement.
Cantoni +31 more
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A novel suicide gene therapy for the treatment of p16-overexpressing tumors [PDF]
, 2017 p16Ink4ais a potent cell cycle inhibitor engaged to support cell cycle arrest during cellular senescence. However, in tumors carrying mutations in key downstream effectors, p16Ink4ais highly expressed but fails to block cell proliferation.
Campisi, Judith +2 more
core +2 more sources
Senolytic therapies for healthy longevity [PDF]
Science, 2019 Clearing senescent cells with targeted drugs could combat age-associated ...
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Is Senolytic Therapy in Cardiovascular Diseases Ready for Translation to Clinics?
BiomoleculesAging is a predominant risk factor for cardiovascular diseases. There is evidence demonstrating that senescent cells not only play a significant role in organism aging but also contribute to the pathogenesis of cardiovascular diseases in younger ages ...
Zhihong Yang +2 more
doaj +1 more source
NAD+, Senolytics, or Pyruvate for Healthy Aging? [PDF]
Nutrition and Metabolic Insights, 2021 In last decades, healthy aging has become one of research hotspots in life science. It is well known that the nicotinamide adenine dinucleotide oxidized form (NAD+) level in cells decreases with aging and aging-related diseases. Several years ago, one of NAD+ precursors was first demonstrated with its new role in DNA damage repairing in mice ...
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